In situ hybridization of five loci to cattle chromosome 1

Schmutz, S. M.; Moker, J. S.; Berryere, T. G.

doi:10.1159/000015007

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…maps to BTA 1q4 (Schmutz et al 1998), in goats it maps to CHI 3q2.1 , and in sheep it maps to chromosome 1 in the region corresponding to CHI 3 and BTA 3. It seems more likely that the ancestor of OAR1 split in separate places to generate chromosomes 1 and 3 of cattle and goat, than that the ancestral chromosomes for CHI/BTA 1 and 3 would have fused to form OAR 1, and that the region containing the THH gene would then have moved from BTA 3 to 1.…”

Section: Discussionmentioning

confidence: 99%

An Enhanced Linkage Map of the Sheep Genome Comprising More Than 1000 Loci

Maddox¹

2001

Genome Research

210

136

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A medium-density linkage map of the ovine genome has been developed. Marker data for 550 new loci were generated and merged with the previous sheep linkage map. The new map comprises 1093 markers representing 1062 unique loci (941 anonymous loci, 121 genes) and spans 3500 cM (sex-averaged) for the autosomes and 132 cM (female) on the X chromosome. There is an average spacing of 3.4 cM between autosomal loci and 8.3 cM between highly polymorphic [polymorphic information content (PIC) Ն 0.7] autosomal loci. The largest gap between markers is 32.5 cM, and the number of gaps of >20 cM between loci, or regions where loci are missing from chromosome ends, has been reduced from 40 in the previous map to 6. Five hundred and seventy-three of the loci can be ordered on a framework map with odds of >1000 : 1. The sheep linkage map contains strong links to both the cattle and goat maps. Five hundred and seventy-two of the loci positioned on the sheep linkage map have also been mapped by linkage analysis in cattle, and 209 of the loci mapped on the sheep linkage map have also been placed on the goat linkage map. Inspection of ruminant linkage maps indicates that the genomic coverage by the current sheep linkage map is comparable to that of the available cattle maps. The sheep map provides a valuable resource to the international sheep, cattle, and goat gene mapping community.Sheep play an important role in modern agriculture and possess many heritable traits that are of economic importance. Additionally, the size, physiology, temperament, and lifespan of sheep make them an appropriate model for studying a variety of mammalian biological functions including lung physiology, immunology, endocrinology, reproduction, embryology, and fetal development. Sheep are also useful as disease models for inherited diseases, such as asthma (Wright et al.

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Section: Discussionmentioning

confidence: 99%

An Enhanced Linkage Map of the Sheep Genome Comprising More Than 1000 Loci

Maddox¹

2001

Genome Research

210

136

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“…maps to BTA 1q4 (Schmutz et al 1998), in goats it maps to CHI 3q2.1 (Schibler et al 1998), and in sheep it maps to chromosome 1 in the region corresponding to CHI 3 and BTA 3. It seems more likely that the ancestor of OAR1 split in separate places to generate chromosomes 1 and 3 of cattle and goat, than that the ancestral chromosomes for CHI/BTA 1 and 3 would have fused to form OAR 1, and that the region containing the THH gene would then have moved from BTA 3 to 1.…”

Section: Linkage Map Of the Sheep Genomementioning

confidence: 99%

An Enhanced Linkage Map of the Sheep Genome Comprising More Than 1000 Loci

Maddox

Davies²,

Crawford³

et al. 2001

Genome Res.

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A medium-density linkage map of the ovine genome has been developed. Marker data for 550 new loci were generated and merged with the previous sheep linkage map. The new map comprises 1093 markers representing 1062 unique loci (941 anonymous loci, 121 genes) and spans 3500 cM (sex-averaged) for the autosomes and 132 cM (female) on the X chromosome. There is an average spacing of 3.4 cM between autosomal loci and 8.3 cM between highly polymorphic [polymorphic information content (PIC) ≥ 0.7] autosomal loci. The largest gap between markers is 32.5 cM, and the number of gaps of >20 cM between loci, or regions where loci are missing from chromosome ends, has been reduced from 40 in the previous map to 6. Five hundred and seventy-three of the loci can be ordered on a framework map with odds of >1000 : 1. The sheep linkage map contains strong links to both the cattle and goat maps. Five hundred and seventy-two of the loci positioned on the sheep linkage map have also been mapped by linkage analysis in cattle, and 209 of the loci mapped on the sheep linkage map have also been placed on the goat linkage map. Inspection of ruminant linkage maps indicates that the genomic coverage by the current sheep linkage map is comparable to that of the available cattle maps. The sheep map provides a valuable resource to the international sheep, cattle, and goat gene mapping community.

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Mapping of 195 genes in cattle and updated comparative map with man, mouse, rat and pig

Hayes¹,

Elduque²,

Gautier³

et al. 2003

Cytogenet Genome Res

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Our on-going goal is to improve and update the comparative genome organization between cattle and man but also among the most detailed mammalian species genomes i.e. cattle, mouse, rat and pig. In this work, we localized 195 genes in cattle and checked all human/bovine non-concordant localizations found in the literature. Next, we compiled all the genes mapped in cattle, goat, sheep and pig (2,166) for which the human ortholog with its chromosomal position is known, added corresponding data in mouse and rat, and ordered the genes relatively to the human genome sequence. We estimate that our compilation provides bovine mapping information for about 89% of the human autosomes. Thus, a near complete, overall and detailed picture of the number, distribution and extent of bovine conserved syntenies (regardless of gene order) on human R-banded autosomes is proposed as well as a comparison with mouse, rat and pig genomes.

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In situ hybridization of five loci to cattle chromosome 1

Cited by 3 publications

References 27 publications

An Enhanced Linkage Map of the Sheep Genome Comprising More Than 1000 Loci

An Enhanced Linkage Map of the Sheep Genome Comprising More Than 1000 Loci

An Enhanced Linkage Map of the Sheep Genome Comprising More Than 1000 Loci

Mapping of 195 genes in cattle and updated comparative map with man, mouse, rat and pig

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