In-situ formation of polyvinylidene fluoride microspheres within polycaprolactone electrospun mats

Balzamo, Gianluca; Bosbach, Wolfram A.; Mele, Elisa

doi:10.1016/j.polymer.2019.122087

Cited by 8 publications

(5 citation statements)

References 46 publications

(53 reference statements)

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“…It has been reported that the Young's modulus of PCL fibrous mats can be increased by welding procedures, such as vapour treatment and thermal annealing [32,33]. These methods induce interfibre bonding that limits fibre movement and slipping during stretching, with a consequent increase in mat resistance to deformation [34]. Load vs. extension curves of: 3D printed PCL-PGS, without (a) and with (b) the electrospun PCL-PGS mat; 3D printed PCL-PGS with 5 wt% of BGs, without (c) and with (d) the electrospun PCL-PGS mat; 3D printed PCL-PGS with 10 wt% of BGs, without (e) and with (f) the electrospun PCL-PGS mat.…”

Section: Characterisation Of the Tensile Response Of The Pcl-pgs-bgs mentioning

confidence: 99%

“…It has been reported that the Young's modulus of PCL fibrous mats can be increased by welding procedures, such as vapour treatment and thermal annealing [32,33]. These methods induce interfibre bonding that limits fibre movement and slipping during stretching, with a consequent increase in mat resistance to deformation [34]. When the fibres were deposited onto the 3D printed PCL-PGS scaffolds, a significant rise in the Young's modulus of the composite scaffolds was observed: from (102 ± 5) MPa for 3D PCL-PGS samples to (250 ± 12) MPa for 3D-ES PCL-PGS ones.…”

Section: Characterisation Of the Tensile Response Of The Pcl-pgs-bgs mentioning

confidence: 99%

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Multi-layer Scaffolds of Poly(caprolactone), Poly(glycerol sebacate) and Bioactive Glasses Manufactured by Combined 3D Printing and Electrospinning

2020

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Three-dimensional (3D) printing has been combined with electrospinning to manufacture multi-layered polymer/glass scaffolds that possess multi-scale porosity, are mechanically robust, release bioactive compounds, degrade at a controlled rate and are biocompatible. Fibrous mats of poly (caprolactone) (PCL) and poly (glycerol sebacate) (PGS) have been directly electrospun on one side of 3D-printed grids of PCL-PGS blends containing bioactive glasses (BGs). The excellent adhesion between layers has resulted in composite scaffolds with a Young’s modulus of 240–310 MPa, higher than that of 3D-printed grids (125–280 MPa, without the electrospun layer). The scaffolds degraded in vitro by releasing PGS and BGs, reaching a weight loss of ~14% after 56 days of incubation. Although the hydrolysis of PGS resulted in the acidification of the buffer medium (to a pH of 5.3–5.4), the release of alkaline ions from the BGs balanced that out and brought the pH back to 6.0. Cytotoxicity tests performed on fibroblasts showed that the PCL-PGS-BGs constructs were biocompatible, with cell viability of above 125% at day 2. This study demonstrates the fabrication of systems with engineered properties by the synergy of diverse technologies and materials (organic and inorganic) for potential applications in tendon and ligament tissue engineering.

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Section: Characterisation Of the Tensile Response Of The Pcl-pgs-bgs mentioning

confidence: 99%

“…It has been reported that the Young's modulus of PCL fibrous mats can be increased by welding procedures, such as vapour treatment and thermal annealing [32,33]. These methods induce interfibre bonding that limits fibre movement and slipping during stretching, with a consequent increase in mat resistance to deformation [34]. When the fibres were deposited onto the 3D printed PCL-PGS scaffolds, a significant rise in the Young's modulus of the composite scaffolds was observed: from (102 ± 5) MPa for 3D PCL-PGS samples to (250 ± 12) MPa for 3D-ES PCL-PGS ones.…”

Section: Characterisation Of the Tensile Response Of The Pcl-pgs-bgs mentioning

confidence: 99%

Multi-layer Scaffolds of Poly(caprolactone), Poly(glycerol sebacate) and Bioactive Glasses Manufactured by Combined 3D Printing and Electrospinning

2020

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“…Electrospraying technology is an attractive method to prepare microspheres with various morphologies. Using this technology, dispersed micron to nanometer‐sized microspheres or particles can usually be obtained 35–37 . Because its operation process is much simpler and easier to control.…”

Section: Introductionmentioning

confidence: 99%

“…Using this technology, dispersed micron to nanometer-sized microspheres or particles can usually be obtained. [35][36][37] Because its operation process is much simpler and easier to control. It is reported that the prepared microspheres by this method are more likely to have large specific surface area, ideal morphology and longer carrier life, which could also expand the application range of microspheres.…”

mentioning

confidence: 99%

Phosphoglyceride‐coated polylactic acid porous microspheres and its regulation of curcumin release behavior

Shen

Ning

et al. 2022

J of Applied Polymer Sci

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Polymer microspheres are widely used as carriers in delivering of hydrophobic or hydrophilic drugs. Surface coating of microspheres could be one of the attractive strategies to improve their properties. In this study, biodegradable polymer polylactic acid was dissolved in chloroform and non-solvent to electrospray porous polymer microspheres. The properties of the microspheres were improved by phosphoglyceride (P-P-Gly) coating, and its behavior was investigated by loading with curcumin as a model drug. The morphologies of different microspheres were observed by scanning electron microscope. The results indicated that the microspheres obtained by dimethyl sulfoxide as nonsolvent could form the structure with porous characteristics. X-ray diffraction, X-ray photoelectron spectroscopy, and Fourier transform infrared spectroscopy analysis revealed that P-P-Gly was successfully coated on the surface of the microspheres. In addition, the thermal behavior of the coated microspheres was investigated by differential scanning calorimetry. In vitro release experiments indicated that the drug-loaded microspheres showed a very gentle release trend, which was mainly due to the P-P-Gly coating could not completely cover the pores of the microspheres. The P-P-Gly-coated microspheres prepared in this work can be used as controlled release drug carriers with special needs.

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“…Strategies to further enhance the relevance of electrospun materials for tissue engineering applications have recently led to novel three-dimensional (3D) scaffolds with multi-scale hierarchical architectures ( Moroni et al, 2008 ; Dalton et al, 2013 ; Balzamo et al, 2020 ; Chen et al, 2020a ; Eom et al, 2020 ; Rahmati et al, 2020 ). These have been produced by combining electrospinning with techniques such as electro-spraying, gas foaming, phase separation, freeze-drying, additive manufacturing, leaching, and moulding.…”

Section: Introductionmentioning

confidence: 99%

Electrospinning and Additive Manufacturing: Adding Three-Dimensionality to Electrospun Scaffolds for Tissue Engineering

Smith

Mele

2021

Front. Bioeng. Biotechnol.

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The final biochemical and mechanical performance of an implant or scaffold are defined by its structure, as well as the raw materials and processing conditions used during its fabrication. Electrospinning and Additive Manufacturing (AM) are two contrasting processing technologies that have gained popularity amongst the fields of medical research i.e., tissue engineering, implant design, drug delivery. Electrospinning technology is favored for its ability to produce micro- to nanometer fibers from polymer solutions and melts, of which, the dimensions, alignment, porosity, and chemical composition are easily manipulatable to the desired application. AM, on the other hand, offers unrivalled levels of geometrical freedom, allowing highly complex components (i.e., patient-specific) to be built inexpensively within 24 hours. Hence, adopting both technologies together appears to be a progressive step in pursuit of scaffolds that better match the natural architecture of human tissues. Here, we present recent insights into the advances on hybrid scaffolds produced by combining electrospinning (melt electrospinning excluded) and AM, specifically multi-layered architectures consisting of alternating fibers and AM elements, and bioinks reinforced with fibers prior to AM. We discuss how cellular behavior (attachment, migration, and differentiation) is influenced by the co-existence of these micro- and nano-features.

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In-situ formation of polyvinylidene fluoride microspheres within polycaprolactone electrospun mats

Cited by 8 publications

References 46 publications

Multi-layer Scaffolds of Poly(caprolactone), Poly(glycerol sebacate) and Bioactive Glasses Manufactured by Combined 3D Printing and Electrospinning

Multi-layer Scaffolds of Poly(caprolactone), Poly(glycerol sebacate) and Bioactive Glasses Manufactured by Combined 3D Printing and Electrospinning

Phosphoglyceride‐coated polylactic acid porous microspheres and its regulation of curcumin release behavior

Electrospinning and Additive Manufacturing: Adding Three-Dimensionality to Electrospun Scaffolds for Tissue Engineering

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