In situ formation of biphasic calcium phosphates and their biological performance in vivo

Kim, Tae‐Wan; Park, Young Min; Kim, Dong-Hyun; Jin, Hyeong-Ho; Shin, Keun-Koo; Jung, Jin Sup; Park, Hong-Chae; Yoon, Soon-Do

doi:10.1016/j.ceramint.2011.10.029

Cited by 29 publications

(17 citation statements)

References 31 publications

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“…The relative phase content was quantitatively determined by the relative intensity ratio (RIR) method, using the following equation: [4,5,11]. The RIR of HAP/b-TCP was estimated using the intensity of peaks (2 1 1) and (0 2 10) of HAP and b-TCP, respectively.…”

Section: Characterizationmentioning

confidence: 99%

Mg-doped biphasic calcium phosphate by a solid state reaction route: Characterization and evaluation of cytotoxicity

Webler

Correia

Barreto

et al. 2015

Materials Chemistry and Physics

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Section: Characterizationmentioning

confidence: 99%

Mg-doped biphasic calcium phosphate by a solid state reaction route: Characterization and evaluation of cytotoxicity

Webler

Correia

Barreto

et al. 2015

Materials Chemistry and Physics

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“…The second aim was to assess the effect of magnesium substitution on the in vitro bioactivity of BCP powder. [19]. Magnesium substituted BCP powders with different amount of magnesium (0.5, 1, and 1.5 wt%) were prepared assuming that magnesium ions would substitute for the calcium site in the HAp and b-TCP lattice in order to obtain a nominal composition in terms of (Ca + Mg)/P ratio of 1.602.…”

Section: Introductionmentioning

confidence: 99%

In situ synthesis of magnesium-substituted biphasic calcium phosphate and in vitro biodegradation

Kim¹,

Lee²,

Kim³

et al. 2012

Materials Research Bulletin

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“…The formation of biphasic (HA ? b-TCP) mixtures are usually preferred for bone graft applications because their resorption rate can be tuned to match the bone healing rate allowing to obtain a suitable balance between implant degradation and bone regeneration [47].…”

Section: Discussionmentioning

confidence: 99%

Insights on the properties of levofloxacin-adsorbed Sr- and Mg-doped calcium phosphate powders

Marques

Matos

Ribeiro

et al. 2016

J Mater Sci: Mater Med

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Several types of biodegradable materials have been investigated for the treatment of osteomyelitis. Calcium phosphate (CaP) ceramics are among the most performing materials due to their resemblance to human hard tissues in terms of mineralogical composition, and proven ability to adsorb and deliver a number of drugs. This research work was intended to study the suitability of modified CaP powders loaded with a fluoroquinolone as drug delivery systems for osteomyelitis treatment. Levofloxacin (LEV) was chosen due to the well-recognized anti-staphylococcal activity and adequate penetration into osteoarticular tissues. Substituted CaP powders (5 mol% Sr(2+) or 5 mol% Mg(2+)) were synthesised through aqueous precipitation. The obtained powders were characterised by X-ray diffraction, SEM and FTIR analysis. The X-ray diffraction patterns confirmed the presence of HA and β-tricalcium phosphates (β-TCP) phases in doped compositions, especially in the case of Mg-doped system. The fixation of LEV at the surface of the particles occurred only by physisorption. Both the in vitro microbiological susceptibility, against Staphylococcus spp, and biocompatibility of LEV-loaded CaP powders have not been compromised.

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In situ formation of biphasic calcium phosphates and their biological performance in vivo

Cited by 29 publications

References 31 publications

Mg-doped biphasic calcium phosphate by a solid state reaction route: Characterization and evaluation of cytotoxicity

Mg-doped biphasic calcium phosphate by a solid state reaction route: Characterization and evaluation of cytotoxicity

In situ synthesis of magnesium-substituted biphasic calcium phosphate and in vitro biodegradation

Insights on the properties of levofloxacin-adsorbed Sr- and Mg-doped calcium phosphate powders

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