Mg-doped biphasic calcium phosphate by a solid state reaction route: Characterization and evaluation of cytotoxicity

Webler, Geovana Dresch; Correia, A. C. C.; Barreto, Emiliano; Fonseca, Eduardo J.S.

doi:10.1016/j.matchemphys.2015.05.055

Cited by 18 publications

(8 citation statements)

References 22 publications

(46 reference statements)

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“…26 The band between 2500-2600 cm À1 corresponds to the CO 2 present in the atmosphere. 42 Additionally, the value of absolute quantum yield (QY) was measured to be 4.36%, which was comparable to the reported CDs. 26,43,44 EDX and corresponding elemental mapping analysis were further used to conrm the presence of the elements C, O and N (Fig.…”

Section: Characterization Of Carbon Dotssupporting

confidence: 78%

Temperature-dependence on the optical properties of chitosan carbon dots in the solid state

et al. 2021

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Section: Characterization Of Carbon Dotssupporting

confidence: 78%

Temperature-dependence on the optical properties of chitosan carbon dots in the solid state

et al. 2021

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“…Recently, BCPs consisting of a mixture of HA and β‐TCP have been considered as potential bone substitutes for bone replacement surgical operations because they combine the distinct advantages of stable HA and resorbable β‐TCP. HA is well known for its similarity to the mineral phase of bone, but it has a limited ability to stimulate the development of new bone tissue and it does not degrade in a significant way 15 . On the other hand, β‐TCP has a more favorable biodegradation rate than HA.…”

Section: Mg‐doping Of Calcium Phosphates Toward Developing Mg‐bcpmentioning

confidence: 99%

“…Several synthetic methods have been developed to prepare Mg‐BCP powders with variable (Ca + Mg)/P ratios. Table 3 summarizes the methods that have been proven to successfully produce Mg‐BCP powders, including chemical wet‐precipitation, 4,43,48,51,53–56 sol–gel, 47,49,50 single diffusion gel, 57 and solid state reactions 15 . The most common chemical precursors used are calcium nitrate tetrahydrate [Ca(NO 3 ) 2 .4H 2 O] as the calcium source, magnesium nitrate hexahydrate [Mg(NO3)2.6H2O] as the magnesium source, and diammonium hydrogen phosphate [(NH4)2HPO4] as the phosphorous source.…”

Section: Mg‐bcp Synthesis and Preparationmentioning

confidence: 99%

“…Based on the search of Web of Science and Google Scholar through May 2020, only four studies evaluated the cytocompatibility of Mg‐BCP. The tested cells included macrophage‐like J774 cells, 15 human adipose‐derived mesenchymal stem cells, 53,54 and osteoblasts isolated from the calvaria of neonatal Wistar rats 51 . An inflammatory response at the bone injury site is the first step to initiating the healing process.…”

Section: Biocompatibility Of Mg‐bcpmentioning

confidence: 99%

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Biocompatiblemagnesium‐dopedbiphasic calcium phosphate for bone regeneration

et al. 2021

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Autologous bone grafting remains the gold standard for almost all bone void‐filling orthopedic surgery. However, autologous bone grafting has several limitations, thus scientists are trying to identify an ideal synthetic material as an alternative bone graft substitute. Magnesium‐doped biphasic calcium phosphate (Mg‐BCP) has recently been in the spotlight and is considered to be a potential bone substitute. The Mg‐BCP is a mixture of two bioceramics, that is, hydroxyapatite (HA) and β‐tricalcium phosphate (β‐TCP), doped with Mg2+, and can be synthesized through chemical wet‐precipitation, sol–gel, single diffusion gel, and solid state reactions. Regardless of the synthesis routes, it is found that the Mg2+ preferentially accommodates in β‐TCP lattice instead of the HA lattice. The addition of Mg2+ to BCP leads to desirable physicochemical properties and is found to enhance the apatite‐forming ability as compared to pristine BCP. In vitro results suggest that the Mg‐BCP is bioactive and not toxic to cells. Implantation of Mg‐BCP in in vivo models further affirmed its biocompatibility and efficacy as a bone substitute. However, like the other bioceramics, the optimum physicochemical properties of the Mg‐BCP scaffold have yet to be determined. Further investigations are required regarding Mg‐BCP applications in bone tissue engineering.

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“…Therefore, in many cases, the effects attributed to one element in the doped hydroxyapatites are mixed with those caused by the presence of phases that are unaccounted for. For instance, Webler et al 28 observed that the level of Mg 2+ and the concentration of phases in biphasic ceramics (β-TCP/hydroxyapatite) had no effect on macrophage viability after 24 h of culture. In this case, two factors were simultaneously influencing this system: Mg 2+ and the β-TCP/hydroxyapatite concentration.…”

Section: -mentioning

confidence: 99%

Isolating the Effects of Mg2+, Mn2+ and Sr2+ Ions on Osteoblast Behavior from those Caused by Hydroxyapatite Transformation

2020

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Ionic trace elements such as Mg 2+ , Mn 2+ and Sr 2+ are very difficult to stabilize in the hydroxyapatite lattice, and they can induce phase transformations when subjected to thermal treatments. The effects of the ions themselves are often confused with the effects of the newly formed phases. Therefore, the objective of this work was to evaluate the effects of the ions isolated from the effects caused by the inherent phase transformations observed in these systems. WDXRF, XRD, FTIR and biological assays using mouse preosteoblastic cells (MC3T3-E1) showed the Mg 2+ ions can stimulate cell differentiation even when segregated from the HA structure in the form of MgO. However, the presence of MgO considerably retards cell proliferation. At the same time, Mn 2+ ions are able to increase cell proliferation and induce the production of high levels of ALP, regardless of whether they are inserted into the HA structure or segregated in the form of Mn 3 O 4. Finally, the presence of Sr 2+ in the HA lattice does not appear to directly affect cell behavior, since both the proliferation and production of ALP are comparable to those observed in the nondoped HA sample.

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Mg-doped biphasic calcium phosphate by a solid state reaction route: Characterization and evaluation of cytotoxicity

Cited by 18 publications

References 22 publications

Temperature-dependence on the optical properties of chitosan carbon dots in the solid state

Temperature-dependence on the optical properties of chitosan carbon dots in the solid state

Biocompatiblemagnesium‐dopedbiphasic calcium phosphate for bone regeneration

Isolating the Effects of Mg2+, Mn2+ and Sr2+ Ions on Osteoblast Behavior from those Caused by Hydroxyapatite Transformation

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