In situ fabrication of chiral covalent triazine frameworks membranes for enantiomer separation

Recent Advances in Separation and Analysis of Chiral Compounds

“…= 21.7%). 149 It seems that either MMMs or TFNs are difficult to achieve both high selectivity and permeability. These types of membranes obviously cannot meet the requirements of industrial production and need to be further optimized from membrane fabrication to improve the selectivity, permeability, and other mechanical properties.…”

“…This membrane enabled the high-flux enantiomer separation of drug intermediates and drug, such as R/S-1-phenylethanol (e.e. = 21.7%) . It seems that either MMMs or TFNs are difficult to achieve both high selectivity and permeability.…”

Chiral fluorescence recognition of glutamine enantiomers by a modified Zr-based MOF based on solvent-assisted ligand incorporation

“…A fused silica capillary with dimensions of 50 μm id and effective length of 40 cm was used for the separation of the analytes. The e.e.% was calculated by the following formula, 42 where A D and A L represent the peak areas of d - and l -Gln, respectively. …”

Challenges and opportunities for chiral covalent organic frameworks

“…23 ). 77 CCTF membranes exhibited good enantioselectivity for the analytes, including 1-phenylethanol, 1,1-binaphthol, and ibuprofen, by the synergistic interaction between unique chiral channel structures and hydrogen bonds. Again, CC-DMP CCTF displayed better enantioselectivity for chiral drugs as compared to CC-MP CCTF under the same conditions due to the difference in the adsorption energy and the dimension matching for the enantiomers between CC-DMP CCTF and CC-MP CCTF.…”

“…Again, transmembrane permeation tests also demonstrated the CD-COF-1 MMM penetrated L-His much faster than D-His, probably due to the synergistic effect between the osmotic pressure difference and enantioselective adsorption and desorption. This work lays a foundation for the development of novel COF-based membranes to selectively transport chiral biomolecules.Hu et al demonstrated that novel chiral covalent triazine framework (CCTF) membranes based on porous quartz substrate fiber membranes were constructed through the ''in situ growth'' method, and applied in the chiral separation of drug enantiomers (Fig.23) 77. CCTF membranes exhibited good enantioselectivity for the analytes, including 1-phenylethanol, 1,1-binaphthol, and ibuprofen, by the synergistic interaction between unique chiral channel structures and hydrogen bonds.…”