In situ effect of titanium tetrafluoride varnish on enamel demineralization

Alexandria, Adílis Kalina; Nassur, Camila; Nóbrega, Camila Costa da; Valença, Ana Maria Gondim; Rosalen, Pedro Luiz; Maia, Lucianne Cople

doi:10.1590/1807-3107bor-2017.vol31.0086

Cited by 20 publications

(17 citation statements)

References 23 publications

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“…Concerning elemental analysis using EDS, it was observed similar Ca, P and Ca/P ratio percentages among groups. Previous studies also observed similar patterns of Ca and P when different fluoride compounds were used (Alexandria et al, 2017; Amaechi et al, 2013), and F was not detectable after treatments. Caution should be used to interpret these results since EDS is considered a semiquantitative analytical method and resolution technique, the incident or excitation beam and penetration depth should be considered.…”

Section: Discussionsupporting

confidence: 67%

Fluoride release and remineralizing potential of varnishes in early caries lesions in primary teeth

Soares‐Yoshikawa

Varanda

Iwamoto

et al. 2020

Microscopy Res & Technique

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This study evaluated the fluoride (F) release and remineralizing potential of varnishes containing sodium fluoride (5% NaF), 5% NaF with CPP‐ACP and 5% NaF with TCP in early caries lesions in primary teeth. To determine the F release at 1, 4, 6, 24, 72, and 168 hr, strips were covered with the varnishes and immersed in purified water (n = 7). The varnishes and purified water (negative control) were applied on enamel blocks with early caries lesions (n = 16). Enamel blocks were stored in artificial saliva and submitted to a pH‐cycling. The area of enamel hardness loss (ΔS) was analyzed by microhardness, lesion depth by polarized light microscopy (PLM) and the chemical analysis by Energy‐dispersive X‐ray spectroscopy. Data were submitted to Shapiro–Wilk, two‐way and one‐way ANOVA, Tukey and paired t‐tests (α = 5%). All varnishes released F, but 5% NaF with CPP‐ACP had the highest release at 4, 6, 24, and 72 hr (p < .05) followed by 5% NaF with TCP and 5% NaF. No significant difference in ΔS was observed among varnishes (5% NaF = 4,098.4 ± 1,407.9; 5% NaF with CPP‐ACP = 4,164.0 ± 1,019.3; 5% NaF with TCP = 4,183.2 ± 1,527.2; p = .999), but all of them differed from the negative control group (6,757.8 ± 2,274.7; p < .001). Lesion depth was lower in varnishes groups compared to negative control (% reduction: 5% NaF = 41.8%, 5% NaF with CPP‐ACP = 38.8%, and 5% NaF with TCP = 36.3%; p < .001). Similar Ca, P, and Ca/P ratio percentages among groups and F was not detected after the treatments. All fluoride varnishes showed potential to enhance remineralization of early caries lesions in primary teeth.

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Section: Discussionsupporting

confidence: 67%

Fluoride release and remineralizing potential of varnishes in early caries lesions in primary teeth

Soares‐Yoshikawa

Varanda

Iwamoto

et al. 2020

Microscopy Res & Technique

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“…Fluoride varnish had significantly decreased interproximal enamel demineralization which had been assessed by scanning electron microscopy (SEM) and energy dispersive X-ray (EDS) in an in vitro study (P < 0.05) (30). In an in situ observation of enamel demineralization by SEM and EDS, titanium tetrafluoride varnish could significantly decrease enamel demineralization (P < 0.05) (31). Fluoride varnish has a sticky potential on teeth, therefore calcium fluoride precipitate as a source of fluoride ions for low pH plaques.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Application of Different Fluoride Supplements on Enamel Demineralization Adjacent to Orthodontic Brackets: An In Vitro Study

et al. 2019

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Background: White spot lesion is considered as one of the main problems in the orthodontic treatment. Brackets used in fixed orthodontic treatment create an environment that provides enamel demineralization. Objectives: The objective of the current study was to perform an in vitro study to compare different applications of fluoride supplements on enamel demineralization adjacent to orthodontic brackets and finally to understand the best supplement to recommend the patients. Methods: One hundred and twenty extracted caries-free human premolar teeth were randomly assigned into six groups: group 1: Control group, group 2: Fluoride toothpaste, group 3: Fluoride toothpaste/mouth rinse, group 4: Fluoride toothpaste/vanish, group 5: Fluoride toothpaste/gel and group 6: Fluoride toothpaste/foam. After bonding the brackets to the teeth, the fluoride supplements were applied based on each group above, except the control group. Then all the specimens were cycled for 30 days in demineralization solution for 8 hours a day, rinsed, placed in artificial saliva for 4 hours a day, brushed (except the control group), and put back to artificial saliva for 12 hours. DIAGNOdent laser fluorescence was used to quantify the demineralization changes. Results: Significant differences existed between all fluoride-containing groups and control group. Analyses of the results showed a significant difference between control group and the rest 5 treatment groups (P < 0.001). Other significant differences were between groups 2/5, 3/5, 2/4 and 5/6 (P < 0.05). There was no significant difference among the other groups (P > 0.05). Conclusions: According to the results, all fluoride supplements could be used during orthodontic treatment to decrease the enamel demineralization. It has been illustrated that fluoride-containing toothpaste and mouth rinse is better than no fluoride treatment but is not effective as well as fluoride gel and varnish.

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“…Given the paucity of previous studies on the topic, this randomized, controlled, single-blind, in vitro study took into account a sample size (n=13 per group) based on the mineral loss of compounds containing calcium and fluoride (16,17). Therefore, a 0.8 statistical power was used to detect a significant difference of 50% in average mineral loss in each treatment group when compared to the control group (1.36% of NaF), running a one-tailed test at a 5% significance level (BioEstat 5.3 ® , Instituto de Desenvolvimento Sustentável Mamirauá, Tefé, Brazil).…”

Section: Methodsmentioning

confidence: 99%

In vitro effect of experimental nanocomposites solutions on the prevention of dental caries around orthodontic brackets

et al. 2021

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This study aimed to evaluate the in vitro effect of a single application of experimental nanocomposite solutions on the prevention of dental caries around orthodontic brackets. The specimens were exposed to mesoporous silica (MS) nanocomposites containing fluoride by association with titanium tetrafluoride (TiF4) or sodium fluoride (NaF). Nanocomposites also could contain calcium and groups were described as MSCaTiF4, MSTiF4, MSCaNaF, MSNaF, and controls (TiF4, and NaF). Specimens were subjected to the formation of a multispecies biofilm to generate a cariogenic challenge. After 24h, both pH and total soluble fluoride concentration of the culture medium were assessed. Mineral loss was evaluated by percentage of surface mineral loss (%SML), mineral volume variation (ΔZ) of inner enamel and polarized light microscopy (PL). Linear (Ra) and volumetric (Sa) surface roughness and scanning electronic microscopy (SEM) were used to assess enamel topography. Statistical analyses were conducted considering p<0.05. MSNaF had the highest value of culture medium pH after cariogenic challenge, similarly to MSTiF4. All nanocomposite solutions released less fluoride than their controls NaF and TiF4 (p<0.05). All nanocomposite solutions presented lower %SML compared to their respective control groups (p<0.05). Lower Ra, Sa and ΔZ were observed for experimental groups compared to TiF4 (p<0.05). The results were confirmed by PL and SEM analysis. The experimental nanocomposite solutions contributed for lower enamel demineralization around orthodontic brackets.

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In situ effect of titanium tetrafluoride varnish on enamel demineralization

Cited by 20 publications

References 23 publications

Fluoride release and remineralizing potential of varnishes in early caries lesions in primary teeth

Fluoride release and remineralizing potential of varnishes in early caries lesions in primary teeth

Comparison of the Application of Different Fluoride Supplements on Enamel Demineralization Adjacent to Orthodontic Brackets: An In Vitro Study

In vitro effect of experimental nanocomposites solutions on the prevention of dental caries around orthodontic brackets

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