In situ derived sulfated/sulfonated carbon nanogels with multi-protective effects against influenza a virus

Lin, Hung-Yun; Luo, Ka-Long; Mao, Ju‐Yi; Lin, Chin‐Jung; Wang, Chen-Yow; Panny, Lauren; Chen, Shiow‐Yi; Lin, Shih‐Chao; Huang, Chih‐Ching; Harroun, Scott G.; Wang, Chia Hui; Wu, Changshan

doi:10.1016/j.cej.2023.141429

Cited by 4 publications

(9 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was also seen with sulfated polysaccharides studied by Baba et al which were active against herpes simplex virus, human cytomegalovirus, vesicular stomatitis virus, Sindbis virus, and human immunodeficiency virus, but not against adenovirus, coxsackievirus, poliovirus, or reovirus 50 . Nonetheless, it is curious to see that some marine sulfated polymers such as spirulan 51 , alginate 52 , and fucoidan 53 can exhibit anti-IAV activity. One possible reason for inconsistencies in anti-IAV activities is that HAs from different IAV subtypes vary significantly at the amino acid level.…”

Section: Discussionmentioning

confidence: 99%

Antiviral activity of marine sulfated glycans against pathogenic human coronaviruses

Zoepfl

Dwivedi

Kim

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Great interest exists towards the discovery and development of broad-spectrum antivirals. This occurs due to the frequent emergence of new viruses which can also eventually lead to pandemics. A reasonable and efficient strategy to develop new broad-spectrum antivirals relies on targeting a common molecular player of various viruses. Heparan sulfate is a sulfated glycosaminoglycan present on the surface of cells which plays a key role as co-receptor in many virus infections. In previous work, marine sulfated glycans (MSGs) were identified as having antiviral activities. Their mechanism of action relies primarily on competitive inhibition of virion binding to heparan sulfate, preventing virus attachment to the cell surface prior to entry. In the current work we used pseudotyped lentivirus particles to investigate in a comparative fashion the inhibitory properties of five structurally defined MSGs against SARS-CoV-1, SARS-CoV-2, MERS-CoV, and influenza A virus (IAV). MSGs include the disaccharide-repeating sulfated galactan from the red alga Botryocladia occidentalis, the tetrasaccharide-repeating sulfated fucans from the sea urchin Lytechinus variegatus and from the sea cucumber Isostichopus badionotus, and the two marine fucosylated chondroitin sulfates from the sea cucumbers I. badionotus and Pentacta pygmaea. Results indicate specificity of action against SARS-CoV-1 and SARS-CoV-2. Curiously, the MSGs showed decreased inhibitory potencies against MERS-CoV and negligible action against IAV. Among the five MSGs, the two sulfated fucans here studied deserve further attention since they have the lowest anticoagulant effects but still present potent and selective antiviral properties.

show abstract

Section: Discussionmentioning

confidence: 99%

Antiviral activity of marine sulfated glycans against pathogenic human coronaviruses

Zoepfl

Dwivedi

Kim

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In their study, they observed that the carbonization could significantly enhance the biological activities of the CNGs, including their antiviral, antioxidant, and anti-inflammatory properties. Furthermore, the authors observed that the sulfated/sulfonated CNGs demonstrated multifaceted protective effects, safeguarding mice from severe health complications caused by IAVs [157]. Taken together, these studies suggested that the one-step carbonization process and the multiple antiviral mechanisms exhibited by these food-based CDs offer significant advantages for biomedical applications targeting viruses (Table 5).…”

Section: Antivirus Activitymentioning

confidence: 96%

“…Table 5 presents the antivirus activities of food-based CDs. In recent studies, a great number of researchers have attempted to explore the antivirus activity of CDs derived from various food additives and dietary compounds, such as boronic acids [156,158], carrageenan [143], glycyrrhizic acid [147], polyethylene glycol (PEG) [165], polyethyleneimine (PEI) [135], pullulan [143], and sodium alginate [157]. It is worth noting that boronic acids, despite being approved by the FDA, have strict limitations regarding their allowable quantity and daily consumption [156,158].…”

Section: Antivirus Activitymentioning

confidence: 99%

“…These CDs have shown promising antiviral activity against a range of viruses, including the white spot syndrome virus (WSSV), influenza A viruses (IAVs), herpesvirus, rhabdovirus, flavivirus, and coronavirus. To give an example, Lin et al [157] employed a combination of sodium alginate and ammonium sulfite, followed by carbonization, to facilitate an in situ sulfuration/sulfonation process of the CNGs. In their study, they observed that the carbonization could significantly enhance the biological activities of the CNGs, including their antiviral, antioxidant, and anti-inflammatory properties.…”

Section: Antivirus Activitymentioning

confidence: 99%

“…Extensive research has also been conducted to confirm the presence of specific antiviralrelated functional groups in various dietary compounds, including flavonoid compounds (e.g., curcumin, hesperidin, and quercetin) and sulfated polysaccharides [119,120,123,130,157,161]. These functional groups have demonstrated the ability to hinder various stages of viral infection within host cells, including attachment, entry, uncoating, replication, assembly, and release (Figure 5).…”

Section: Antivirus Activitymentioning

confidence: 99%

See 2 more Smart Citations

An Overview of the Potential of Food-Based Carbon Dots for Biomedical Applications

Wang,

Ndraha,

et al. 2023

IJMS

Self Cite

View full text Add to dashboard Cite

Food-based carbon dots (CDs) hold significant importance across various fields, ranging from biomedical applications to environmental and food industries. These CDs offer unique advantages over traditional carbon nanomaterials, including affordability, biodegradability, ease of operation, and multiple bioactivities. This work aims to provide a comprehensive overview of recent developments in food-based CDs, focusing on their characteristics, properties, therapeutic applications in biomedicine, and safety assessment methods. The review highlights the potential of food-based CDs in biomedical applications, including antibacterial, antifungal, antivirus, anticancer, and anti-immune hyperactivity. Furthermore, current strategies employed for evaluating the safety of food-based CDs have also been reported. In conclusion, this review offers valuable insights into their potential across diverse sectors and underscores the significance of safety assessment measures to facilitate their continued advancement and application.

show abstract

Pathogen‐binding nanoparticles to inhibit host cell infection by heparan sulfate and sialic acid dependent viruses and protozoan parasites

Najer

2024

Smart Medicine

View full text Add to dashboard Cite

Global health faces an immense burden from infectious diseases caused by viruses and intracellular protozoan parasites such as the coronavirus disease (COVID‐19) and malaria, respectively. These pathogens propagate through the infection of human host cells. The first stage of this host cell infection mechanism is cell attachment, which typically involves interactions between the infectious agent and surface components on the host cell membranes, specifically heparan sulfate (HS) and/or sialic acid (SA). Hence, nanoparticles (NPs) which contain or mimic HS/SA that can directly bind to the pathogen surface and inhibit cell infection are emerging as potential candidates for an alternative anti‐infection therapeutic strategy. These NPs can be prepared from metals, soft matter (lipid, polymer, and dendrimer), DNA, and carbon‐based materials among others and can be designed to include aspects of multivalency, broad‐spectrum activity, biocidal mechanisms, and multifunctionality. This review provides an overview of such anti‐pathogen nanomedicines beyond drug delivery. Nanoscale inhibitors acting against viruses and obligate intracellular protozoan parasites are discussed. In the future, the availability of broadly applicable nanotherapeutics would allow early tackling of existing and upcoming viral diseases. Invasion inhibitory NPs could also provide urgently needed effective treatments for protozoan parasitic infections.

show abstract

In situ derived sulfated/sulfonated carbon nanogels with multi-protective effects against influenza a virus

Cited by 4 publications

References 73 publications

Antiviral activity of marine sulfated glycans against pathogenic human coronaviruses

Antiviral activity of marine sulfated glycans against pathogenic human coronaviruses

An Overview of the Potential of Food-Based Carbon Dots for Biomedical Applications

Pathogen‐binding nanoparticles to inhibit host cell infection by heparan sulfate and sialic acid dependent viruses and protozoan parasites

Contact Info

Product

Resources

About