An Overview of the Potential of Food-Based Carbon Dots for Biomedical Applications

Abstract

Food-based carbon dots (CDs) hold significant importance across various fields, ranging from biomedical applications to environmental and food industries. These CDs offer unique advantages over traditional carbon nanomaterials, including affordability, biodegradability, ease of operation, and multiple bioactivities. This work aims to provide a comprehensive overview of recent developments in food-based CDs, focusing on their characteristics, properties, therapeutic applications in biomedicine, and safety assessment methods. The review highlights the potential of food-based CDs in biomedical applications, including antibacterial, antifungal, antivirus, anticancer, and anti-immune hyperactivity. Furthermore, current strategies employed for evaluating the safety of food-based CDs have also been reported. In conclusion, this review offers valuable insights into their potential across diverse sectors and underscores the significance of safety assessment measures to facilitate their continued advancement and application.

Biofilm Inhibition on Medical Devices and Implants Using Carbon Dots: An Updated Review

“…99 Liu et al, reported an electrostatic interaction mechanism, wherein CDs prepared with citric acid and curcumin completely damaged bacterial cell membranes. 100,101 Likewise, CDs from polyamines and dopamine (SPM/DA-CQDs) were observed to be excellent coatings that prevented biofilm formation on glass and polymeric contact lenses. They selectively inhibited S. aureus biofilm formation by disrupting membrane integrity and causing agglutination.…”

“…Liu et al, reported an electrostatic interaction mechanism, wherein CDs prepared with citric acid and curcumin completely damaged bacterial cell membranes. , Likewise, CDs from polyamines and dopamine (SPM/DA-CQDs) were observed to be excellent coatings that prevented biofilm formation on glass and polymeric contact lenses. They selectively inhibited S. aureus biofilm formation by disrupting membrane integrity and causing agglutination. , CDs synthesized by Ran et al eradicated Gram-positive bacterial biofilms by penetrating bacterial cell surfaces and selective adsorption via electrostatic and hydrophobic interactions . Likewise, Sviridova et al reported inhibition of S. aureus and E. coli biofilms by tetraalkylammonium diazonium salt functionalized CDs in a dose-dependent manner .…”

“…They selectively inhibited S. aureus biofilm formation by disrupting membrane integrity and causing agglutination. 100,101 CDs synthesized by Ran et al eradicated Gram-positive bacterial biofilms by penetrating bacterial cell surfaces and selective adsorption via electrostatic and hydrophobic interactions. 102 Likewise, Sviridova et al reported inhibition of S. aureus and E. coli biofilms by tetraalkylammonium diazonium salt functionalized CDs in a dose-dependent manner.…”