In situ Carcinoma in Branchial Cysts

Abstract

Two cases of in situ squamous cell carcinoma in the epithelium of a branchial cyst are described. These are the only cases reported that fulfill the established criteria for in situ branchial carcinomas.

Malignant first branchial cleft cysts presented as submandibular abscesses in fine‐needle aspiration: Report of three cases and review of literature

“…With extensive review of the English language literature to date there are at least 20 cases of branchiogenic carcinoma (Table I) satisfying Khafif's modified criteria and two cases of in situ carcinoma in branchial cysts. [2][3][4][5][6][7][8][9][10][11][12] We add three patients to the literature based on Khafif's modified criteria and with FNA biopsy findings, surgical correlations, and clinical follow-up. Our three patients have squamous-cell carcinoma arising from type II of the first branchial cleft cyst.…”

“…They have been traditionally found in a triangle formed from the external auditory canal curving to meet the mid-hyoid and tip of the chin. As shown in Table I, most of the malignant branchial cleft cysts reported in the literature are second branchial cleft cysts, [2][3][4][5][6][7][8][9][10][11] and to the best of our knowledge, there is only a single case report of malignant first branchial cleft cyst in the literature. 12 Over a 13-year period, the senior author encountered three cases of submandibular abscess that proved to be malignant first branchial cysts in histological and clinical follow-up.…”