In-situ calibration of the implantable force transducer

Hasler, E.M.; Leonard, Tim

doi:10.1016/s0021-9290(96)80020-0

Cited by 23 publications

(6 citation statements)

References 9 publications

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“…Moreover, the tissue-device complex still had to be calibrated for the actual activities of daily living (ADLs) to relate device voltage to force in only that tissue. Other researchers chose to reduce complete tissue disruption by inserting modified pressure transducers (MPTs), [47][48][49] implantable force transducers (IFTs), [50][51][52][53][54][55][56][57][58] and arthroscopic implantable force probes (AIFPs) [59][60][61] between the collagen fiber bundles.…”

Section: In Vivo Models Of Strain On Soft Tissuesmentioning

confidence: 99%

Key developments that impacted the field of mechanobiology and mechanotransduction

Wall

Butler

Haj

et al. 2017

Journal Orthopaedic Research

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Advances in mechanobiology have evolved through insights from multiple disciplines including structural engineering, biomechanics, vascular biology, and orthopaedics. In this paper, we reviewed the impact of key reports related to the study of applied loads on tissues and cells and the resulting signal transduction pathways. We addressed how technology has helped advance the burgeoning field of mechanobiology (over 33,600 publications from 1970 to 2016). We analyzed the impact of critical ideas and then determined how these concepts influenced the mechanobiology field by looking at the citation frequency of these reports as well as tracking how the overall number of citations within the field changed over time. These data allowed us to understand how a key publication, idea, or technology guided or enabled the field. Initial observations of how forces acted on bone and soft tissues stimulated the development of computational solutions defining how forces affect tissue modeling and remodeling. Enabling technologies, such as cell and tissue stretching, compression, and shear stress devices, allowed more researchers to explore how deformation and fluid flow affect cells. Observation of the cell as a tensegrity structure and advanced methods to study genetic regulation in cells further advanced knowledge of specific mechanisms of mechanotransduction. The future of the field will involve developing gene and drug therapies to simulate or augment beneficial load regimens in patients and in mechanically conditioning organs for implantation. Here, we addressed a history of the field, but we limited our discussions to advances in musculoskeletal mechanobiology, primarily in bone, tendon, and ligament tissues. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:605-619, 2018.

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Section: In Vivo Models Of Strain On Soft Tissuesmentioning

confidence: 99%

Key developments that impacted the field of mechanobiology and mechanotransduction

Wall

Butler

Haj

et al. 2017

Journal Orthopaedic Research

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“…Even so, it should be taken into account that there is considerable variability between specimens making it difficult to compare results (Ahmed et al, 1987). The calibration procedure also depends on the specific characteristics of the study and this justifies the wide variety of technical resources that are being applied such as mechanical loading machines, analytical equations from cadavers, ergometer devices, equilibrium conditions from mechanics and use of pre-calibrated transducers (Komi, 1990;Holden et al, 1994;Herzog et al, 1996;Arndt et al, 1998;Fleming et al, 1999;Meyer et al, 2004).…”

Section: Conventional Sensorsmentioning

confidence: 99%

“…Their sensitivity can vary with joint angle, sensor placement and orientation (An et al, 1990;Fleming and Beynnon, 2004). Besides buckle transducers, two other types of SG based transducers can be used to sense force in ligaments and tendons, namely the implantable force transducer (IFT) (Kear and Smith, 1975;Xu et al, 1992;Glos et al, 1993;Fleming et al, 1994;Herzog et al, 1996;Korvick et al, 1996;Markolf et al, 1998;Fleming et al, 1999;Hall et al, 1999;Fleming et al, 2000;Meyer et al, 2004;Bull et al, 2005) and the modified pressure transducer (MPT) (Holden et al, 1994;Holden et al, 1995). The IFT was introduced in 1992 by Xu et al (1992).…”

Section: Conventional Sensorsmentioning

confidence: 99%

“…Like buckle transducers IFT sensitivity may vary with joint angle, sensor placement and orientation (Xu et al, 1992;Holden et al, 1995;Herzog et al, 1996;Fleming et al, 1999). Depending on the calibration protocol results can vary significantly (Herzog et al, 1996). More repeatable results can be obtained using the in situ calibration method proposed by Herzog et al (1996).…”

Section: Conventional Sensorsmentioning

confidence: 99%

“…Depending on the calibration protocol results can vary significantly (Herzog et al, 1996). More repeatable results can be obtained using the in situ calibration method proposed by Herzog et al (1996). Another important constraint is a nonlinear relationship between the compressive load acting on the sensor and the tensile load applied to the tissue (Glos et al, 1993;Holden et al, 1995;Fleming et al, 1999;Fleming et al, 2000).…”

Section: Conventional Sensorsmentioning

confidence: 99%

See 2 more Smart Citations

From conventional sensors to fibre optic sensors for strain and force measurements in biomechanics applications: A review

Roriz

Carvalho

Frazão

et al. 2014

Journal of Biomechanics

186

105

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In vivo measurement, not only in animals but also in humans, is a demanding task and is the ultimate goal in experimental biomechanics. For that purpose, measurements in vivo must be performed, under physiological conditions, to obtain a database and contribute for the development of analytical models, used to describe human biomechanics. The knowledge and control of the mechanisms involved in biomechanics will allow the optimization of the performance in different topics like in clinical procedures and rehabilitation, medical devices and sports, among others. Strain gages were first applied to bone in a live animal in 40's and in 80's for the first time were applied fibre optic sensors to perform in vivo measurements of Achilles tendon forces in man. Fibre optic sensors proven to have advantages compare to conventional sensors and a great potential for biomechanical and biomedical applications. Compared to them, they are smaller, easier to implement, minimally invasive, with lower risk of infection, highly accurate, well correlated, inexpensive and multiplexable. The aim of this review article is to give an overview about the evolution of the experimental techniques applied in biomechanics, from conventional to fibre optic sensors. In the next sections the most relevant contributions of these sensors, for strain and force in biomechanical applications, will be presented. Emphasis was given to report of in vivo experiments and clinical applications.

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Evolution of functional tissue engineering for tendon and ligament repair

Butler

2022

J Tissue Eng Regen Med

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This review paper is motivated by a Back‐to‐Basics presentation given by the author at the 2022 Orthopaedic Research Society meeting in Tampa, Florida. I was tasked with providing a brief history of research leading up to the introduction of functional tissue engineering (FTE) for tendon and ligament repair. Beginning in the 1970s, this timeline focused on two common orthopedic soft tissue problems, anterior cruciate ligament ruptures in the knee and supraspinatus tendon injuries in the shoulder. Historic changes in the field over the next 5 decades revealed a transformation from a focus more on mechanics (called “bioMECHANICS”) on a larger (tissue) scale to a more recent focus on biology (called “mechanoBIOLOGY”) on a smaller (cellular and molecular) scale. Early studies by surgeons and engineers revealed the importance of testing conditions for ligaments and tendons (e.g., high strain rates while avoiding subject disuse and immobility) and the need to measure in vivo forces in these tissues. But any true tissue engineering and regeneration in these early decades was limited more to the use of auto‐, allo‐ and xenografts than actual generation of stimulated cell‐scaffold constructs in culture. It was only after the discovery of tissue engineering in 1988 and the recognition of frequent rotator cuff injuries in the early 1990s, that biologists joined surgeons and engineers to discover mechanical and biological testing criteria for FTE. This review emphasizes the need for broader and more inclusive collaborations by surgeons, biologists and engineers in the short term with involvement of those in biomaterials, manufacturing, and regulation of new products in the longer term.

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In-situ calibration of the implantable force transducer

Cited by 23 publications

References 9 publications

Key developments that impacted the field of mechanobiology and mechanotransduction

Key developments that impacted the field of mechanobiology and mechanotransduction

From conventional sensors to fibre optic sensors for strain and force measurements in biomechanics applications: A review

Evolution of functional tissue engineering for tendon and ligament repair

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