In situ analysis of nanoparticle soft corona and dynamic evolution

Baimanov, Didar; Wang, Jing; Zhang, Jun; Liu, Ke; Cong, Yalin; Shi, Xiaomeng; Zhang, Xiaohui; Li, Yu Feng; Li, Xiumin; Qiao, Rongrong; Zhao, Yuliang; Zhou, Yunlong; Wang, Liming; Chen, Chunying

doi:10.1038/s41467-022-33044-y

Cited by 80 publications

(66 citation statements)

References 55 publications

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“…[ 198 ] Recently, a biolayer interferometry‐based fishing strategy was developed for in situ analysis of corona protein adsorption and dissociation processes. [ 199 ] In the context of tracking the distribution of nanoformulations in the immune system, in vivo imaging and inductively coupled plasma analysis in combination with fluorescence‐activated cell sorting technology offer quantitative approaches to analyze the accumulation of nanoformulations in specific subsets of immune cells in lymphoid organs. The activation status of immune cells induced by nanoformulations can be revealed by flow cytometry analysis.…”

Section: Discussionmentioning

confidence: 99%

Targeted Cancer Immunotherapy: Nanoformulation Engineering and Clinical Translation

Yang

Yue

et al. 2022

Advanced Science

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With the rapid growth of advanced nanoengineering strategies, there are great implications for therapeutic immunostimulators formulated in nanomaterials to combat cancer. It is crucial to direct immunostimulators to the right tissue and specific immune cells at the right time, thereby orchestrating the desired, potent, and durable immune response against cancer. The flexibility of nanoformulations in size, topology, softness, and multifunctionality allows precise regulation of nano‐immunological activities for enhanced therapeutic effect. To grasp the modulation of immune response, research efforts are needed to understand the interactions of immune cells at lymph organs and tumor tissues, where the nanoformulations guide the immunostimulators to function on tissue specific subsets of immune cells. In this review, recent advanced nanoformulations targeting specific subset of immune cells, such as dendritic cells (DCs), T cells, monocytes, macrophages, and natural killer (NK) cells are summarized and discussed, and clinical development of nano‐paradigms for targeted cancer immunotherapy is highlighted. Here the focus is on the targeting nanoformulations that can passively or actively target certain immune cells by overcoming the physiobiological barriers, instead of directly injecting into tissues. The opportunities and remaining obstacles for the clinical translation of immune cell targeting nanoformulations in cancer therapy are also discussed.

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Section: Discussionmentioning

confidence: 99%

Targeted Cancer Immunotherapy: Nanoformulation Engineering and Clinical Translation

Yang

Yue

et al. 2022

Advanced Science

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“…For example, the composition of the soft corona of chiral cuprous sulfide (Cu 2 S) is chirality-dependent and correlates to its stereo-selective biodistribution 79 . Time-dependent changes to the chirality-mediated soft and hard corona compositions were correlated with decreased blood circulation and trafficking to the liver 79 . Silver NPs typically dissolve into biologically active and highly toxic Ag + ions 80 .…”

Section: Soft and Hard Coronasmentioning

confidence: 99%

The protein corona from nanomedicine to environmental science

2023

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The protein corona spontaneously develops and evolves on the surface of nanoscale materials when they are exposed to biological environments, altering their physiochemical properties and affecting their subsequent interactions with biosystems. In this Review, we provide an overview of the current state of protein corona research in nanomedicine. We next discuss remaining challenges in the research methodology and characterization of the protein corona that slow the development of nanoparticle therapeutics and diagnostics, and we address how artificial intelligence can advance protein corona research as a complement to experimental research efforts. We then review emerging opportunities provided by the protein corona to address major issues in healthcare and environmental sciences. This Review details how mechanistic insights into nanoparticle protein corona formation can broadly address unmet clinical and environmental needs, as well as enhance the safety and efficacy of nanobiotechnology strength also influence surface-binding-induced protein unfolding 45 .For example, adsorption-induced protein conformational changes were quantified by targeting and fluorescently labelling exposed amine groups; these residues, which were originally buried inside the tertiary structures of proteins in native conformations, became exposed because of adsorption-induced conformational disorders 48 . Protein conformational changes can impact protein functionality through the exposure of once-concealed functional epitopes or misfolding that results in complete loss-of-protein function, subsequently impacting 1960s

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“…Wang et al . [ 184 , 185 ] developed a series of synchrotron radiation analytical techniques to elucidate the valence of metal elements in various conditions and illustrate the interaction between NPs and proteins [ 186 , 187 ]. Besides, they comprehensively provided quantitative methods to monitor the content and transformation of NPs in the blood and different tissues [ 188 , 189 ].…”

Section: Conclusion and Future Prospectivementioning

confidence: 99%

Ferroptosis: challenges and opportunities for nanomaterials in cancer therapy

Liu

Zhao

Zhou

et al. 2023

Regenerative Biomaterials

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Ferroptosis, a completely new form of regulated cell death, is mainly caused by an imbalance between oxidative damage and reductive protection and has shown great anti-cancer potential. However, existing small-molecule ferroptosis inducers have various limitations, such as poor water solubility, drug resistance, and low targeting ability, hindering their clinical applications. Nanotechnology provides new opportunities for ferroptosis-driven tumor therapy. Especially, stimuli-responsive nanomaterials stand out among others and have been widely researched because of their unique spatiotemporal control advantages. Therefore, it’s necessary to summarize the application of those stimuli-responsive nanomaterials in ferroptosis. Here, we describe the physiological feature of ferroptosis and illustrate current challenges to induce ferroptosis for cancer therapy. Then, nanomaterials that induce ferroptosis are classified and elaborated according to external and internal stimuli. Finally, the future perspectives in the field are proposed. We hope this review facilitate paving the way for the design of intelligent nano ferroptosis inducers.

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In situ analysis of nanoparticle soft corona and dynamic evolution

Cited by 80 publications

References 55 publications

Targeted Cancer Immunotherapy: Nanoformulation Engineering and Clinical Translation

Targeted Cancer Immunotherapy: Nanoformulation Engineering and Clinical Translation

The protein corona from nanomedicine to environmental science

Ferroptosis: challenges and opportunities for nanomaterials in cancer therapy

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