In silico Study of Chromane Ring Compound Rubranonoside from Plumeria rubra as Anticancer Potential

Surana, Khemchand Rajendra; Mahajan, Sunil

doi:10.48048/tis.2022.3305

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…We made different UV spectra of 10 ppm solutions of Ellagic acid, Glycyrrhizic acid, and Kaempferol by scanning over the range of 300-900 nm with a Shimadzu UV1801 double beam spectrophotometer. We put all three spectra on top of each other and looked at them to find the best detecting wavelength (isobestic point) for measuring Ellagic acid, Glycyrrhizic acid, and Kaempferol all at the same time (Surana and Mahajan, 2022;Yeola et al, 2023).…”

Section: Development Methodmentioning

confidence: 99%

Elaboration and Verification of the HPTLC Methodology for the Simultaneous Estimation of Glycyrrhizic Acid (GLY), Ellagic Acid, and Kaempferolin in Herbal Formulations

P.S,

Santosh,

S.G

et al. 2023

Intern. J. Zool. Invest.

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Glycyrrhizic acid (GLY), Ellagic acid (EA), and kaempferol (KAE) can be detected simultaneously using the suggested herbal formulation using a simple, precise, and proven high performance thin layer chromatography (HPTLC) method. Using Merck TLC aluminum sheets of silica gel G60 F254 with a 200 µm thickness, the separation was carried out using ethyl acetate: toluene: formic acid (4.5:4.5:1 v/v/v) as the mobile phase. The chemical was densitometrically measured in absorbance mode at 265 nm. For ellagic acid, glycyrrhizic acid, and kaempferol, the aforementioned mobile phase yielded discrete peaks with Rf values of 0.41±0.03, 0.28±0.03, and 0.76±0.03, respectively. The linear regression analysis results for the calibration plots for EA, GLY, and KA showed a reasonable linear association in the concentration range of 300-900 ng/spot for all the chemicals, with regression coefficients (r2) of 0.9936, 0.9923, and 0.9919, respectively. For kaempferol, the limits of quantitation and detection were 44.9678 and 136.2661 ng/spot; for GLY, they were 126.6847 and 383.8930 ng/spot; and for EA, they were 62.5197 and 189.4539 ng/spot, respectively. The established HPTLC approach that has been proposed can be used to identify and quantify measurement of EA, GLY, and KAE in their extracts and herbal formulations. In the end, the statistical analysis of the data showed that the approach is both selective and repeatable for estimating every molecule.

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Section: Development Methodmentioning

confidence: 99%

Elaboration and Verification of the HPTLC Methodology for the Simultaneous Estimation of Glycyrrhizic Acid (GLY), Ellagic Acid, and Kaempferolin in Herbal Formulations

P.S,

Santosh,

S.G

et al. 2023

Intern. J. Zool. Invest.

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“…The sample-free wells served as blanks. Every concentration was maintained in triplicate (Surana and Mahajan, 2022).…”

Section: In Vitro Hepatoprotective Activity Using Various Extracts Ag...mentioning

confidence: 99%

Pharmacognostic, Phytochemical and Hepatoprotective Activity of Berries of Vitex agnus- castus

SG,

et al. 2024

Intern. J. Bio. Env. Invest.

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The aim of this study was to assess the hepatoprotective properties of several Vitex agnus-castus berry extracts in vitro utilizing a normal Chang liver cell line and the MTT test. Pharmacognostical investigations identified a number of distinctive traits found in the plant. The ethyl acetate extract yielded a larger percentage than the other extracts when the berries of Vitex agnus-castus were extracted using solvents with increasing polarity. The antioxidant activity was determined using the reducing power ability assay and the H2O2 scavenging method. The ethyl acetate extract showed the highest antioxidant activity compared to the other two extracts; in all processes, its IC50 value was almost equivalent to that of the reference drug ascorbic acid. The highest level of protection against paracetamol-induced hepatotoxicity was provided by the ethyl acetate extract, according to in vitro hepatoprotective experiments conducted on Chang liver cell line. Our research confirmed the hypothesis that Vitex agnus-castus may be a beneficial hepatoprotective herb. It is recommended to conduct more research on identifying the phytoconstituents causing the action.

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“…It is the body's way of getting rid of the irritation and stopping or killing the invading organisms. It also sets the stage for tissue repair (Surana and Mahajan, 2022). It starts when chemical messengers are released from damaged tissue and cells that have moved (Petchi et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Development, Standardization and Evaluation of an Antiarthritic Polyherbal Formulation

Kumar,

Chandrakan

et al. 2024

Intern. J. Bio. Env. Invest.

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The objective of this study was to make an ayurvedic pill that can be used to treat gout. The capsules are tested according to WHO standards and also have pharmacological action done on them. The study's goals were: (i) Analysis of raw materials by doing the preliminary raw materials study, we can learn more about the formulation's raw materials or ingredients, and (ii) To use preformulation studies to make a pill with three herbs. The Asparagus racemosus extract could stop the protenase enzyme, protein denaturation and membrane lysis, but the effect depend on the amount. At a concentration of 0.8 mg, the enzymes that break down proteins, protenase, and membranes were most active. The standard medication, diclofenac sodium 0.2 mg contains more than this. Lippia nodiflora extract (0.8 mg) showed the most protenase enzyme, activity protein denaturation and membrane stability. This was less than the standard medication which is diclofenac sodium 0.2 mg. The extract from Oldenlandia heynei could stop protenase enzyme activity, protein denaturation and membrane lysis, but the effect depended on the amount. When the concentration was 0.8 mg the enzymes that break down proteins, protenase, and membranes were at their strongest. This was lower than the usual drug, diclofenac sodium 0.2 mg. The swelling in the paws went down in both the groups that were given the polyherbal mixture and the groups that were given diclofenac sodium. When paw edema was examined between the groups treated with the polyherbal mixture and the arthritic control group, there was a significant decrease. This shows that the polyherbal mixture stopped the changes in inflammation that come with arthritis, just like diclofenac sodium. This shows that the polyherbal mixture stopped the changes in inflammation that come with arthritis, just like diclofenac sodium.

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In silico Study of Chromane Ring Compound Rubranonoside from Plumeria rubra as Anticancer Potential

Cited by 8 publications

References 15 publications

Elaboration and Verification of the HPTLC Methodology for the Simultaneous Estimation of Glycyrrhizic Acid (GLY), Ellagic Acid, and Kaempferolin in Herbal Formulations

Elaboration and Verification of the HPTLC Methodology for the Simultaneous Estimation of Glycyrrhizic Acid (GLY), Ellagic Acid, and Kaempferolin in Herbal Formulations

Pharmacognostic, Phytochemical and Hepatoprotective Activity of Berries of Vitex agnus- castus

Development, Standardization and Evaluation of an Antiarthritic Polyherbal Formulation

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