Alexander Aliper, Aleksey V. Belikov, Andrew Garazha, Leslie Jellen, Artem Artemov, Maria Suntsova, Alena Ivanova, Larisa Venkova, Nicolas Borisov, Anton Buzdin, Polina Mamoshina, Evgeny Putin, Andrew G. Swick, Alexey Moskalev et al.
Abstract:Populations in developed nations throughout the world are rapidly aging, and the search for geroprotectors, or anti-aging interventions, has never been more important. Yet while hundreds of geroprotectors have extended lifespan in animal models, none have yet been approved for widespread use in humans. GeroScope is a computational tool that can aid prediction of novel geroprotectors from existing human gene expression data. GeroScope maps expression differences between samples from young and old subjects to ag…
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