Abstract:According to DrugAge (http://genomics.senescence.info/drugs/) and Geroprotectors.org (http://geroprotectors.org/) databases nowadays more than 200 compounds which elongate lifespan of model organisms exist. One of the most promising approaches constitutes aging-associated pathways (insulin/IGF-1, mTOR, NF-κB, PI3k, etc.) as main targets for new perspective geroprotectors' screening. In the current review we summarized the data touching upon geroprotectors that target signaling pathways which are involved in st… Show more
“…Обобщая представленные в литературе факты [21], можно сказать, что в основе старения и возраст-зависимых заболеваний лежат общие элементарные патофизиологические процессы. Между болезнями старения и физиологическим старением различия не в механизмах, а в скорости протекания этих процессов.…”
“…Обобщая представленные в литературе факты [21], можно сказать, что в основе старения и возраст-зависимых заболеваний лежат общие элементарные патофизиологические процессы. Между болезнями старения и физиологическим старением различия не в механизмах, а в скорости протекания этих процессов.…”
In connection with the increase in the average age of the world's population, the problem of preventing premature aging and the treatment of age-related diseases is coming to the fore. The main direction in the implementation of this goal is to influence the key molecular mechanisms of aging in order to suppress pathological processes and activate the defense systems of the cell and the body as a whole. In order to solve this daunting task, it is necessary to have in the arsenal not only various means of intervention in the aging process, but also diagnostic methods that would allow to fully verify these processes and evaluate the effectiveness of medical interventions.
N-acetyl-L-cysteine (NAC) is a derivative of the sulphur-containing amino acid L-cysteine with potential anti-aging properties. We studied 3 Drosophila species with contrast longevity differences (D. virilis is longest-lived, D. kikkawai is shortest-lived and D. melanogaster has moderate lifespan) to test the effects of NAC at 8 different concentrations (from 10 nM to 100 mM) on the lifespan, stress-resistance and locomotor activity. Except the adverse effects of highest (10 mM and 100 mM) concentrations NAC demonstrated sexually opposite and male-biased effects on Drosophila lifespan, stress-resistance and locomotor activity and not satisfied the criteria of a geroprotector in terms of the reproducibility of lifespan extending effects in different model organisms. The concentration- and sex-dependent changes in the relative expression levels of the antioxidant genes (Cat/CG6871 and Sod1/CG11793) and genes involved in hydrogen sulfide biosynthesis (Cbs/CG1753, Eip55E/CG5345 and Nfs1/CG12264) suggest the involvement of hormetic mechanisms in the geroprotective effects of NAC.
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