In Quest of a Systematic Framework for Unifying and Defining Nanoscience

Tomalia, Donald A.

doi:10.1142/s0217984914300026

Cited by 35 publications

(83 citation statements)

References 188 publications

(192 reference statements)

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“…Thus, dendrimers bearing voluminous cations on the periphery are better for the transfection. This observation provides a vector for the rational design of the dendrimer-based pharmaceuticals [33,34] according to the critical parameters of the molecular design [35][36][37].…”

Section: Discussionmentioning

confidence: 98%

Multi-Target Inhibition of Cancer Cell Growth by SiRNA Cocktails and 5-Fluorouracil Using Effective Piperidine-Terminated Phosphorus Dendrimers

Ihnatsyeu-Kachan

Dzmitruk

Apartsin

et al. 2017

Colloids and Interfaces

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Currently, RNAi based approaches for cancer treatment involving short double stranded RNA molecules (siRNA) are under vigorous scrutinization. Due to numerous biological obstacles, siRNA delivery into target cells requires protective escort. On the other hand, combining of siRNA-mediated gene silencing and action of conventional chemotherapeutics can propose additional enhancement of anticancer activity. In the present study, we investigated a siRNA cocktail able to downregulate anti-apoptotic genes (BCL-xL, BCL-2, MCL-1) and the chemotherapeutic agent 5-fluorouracil (5-FU) to evaluate multi-target cytotoxic effect on human cervical carcinoma cells (HeLa cell line). Novel phosphorus containing dendrimers of 3rd and 4th generations (namely AE2G3 and AE2G4) with voluminous piperidine terminal cationic groups were designed and tested as siRNA carriers. Dendrimers of both generations showed remarkable ability to bind pro-apoptotic siRNAs and provided 80-100% siRNA uptake by HeLa cells in the serum containing medium, while the widespread transfection agent Lipofectamine showed only~40% uptake. SiRNA cocktail (in low concentrations 50 and 100 nM) delivered by AE2G3 dendrimer caused almost complete elimination of cancer cells. We have discovered considerable increase of 5-FU cytotoxic effect by addition of AE2G3/siRNA cocktail complexes in low doses. Thus, we demonstrated the effectiveness of combined multi-target siRNA anticancer approach and described new highly effective serum stable nanomaterial vehicle for gene-based drugs.

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Section: Discussionmentioning

confidence: 98%

Multi-Target Inhibition of Cancer Cell Growth by SiRNA Cocktails and 5-Fluorouracil Using Effective Piperidine-Terminated Phosphorus Dendrimers

Ihnatsyeu-Kachan

Dzmitruk

Apartsin

et al. 2017

Colloids and Interfaces

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“…The history of dendrimers started about 30 years ago, and today there are many kinds that all share a similar structure. Dendrimers are quite different from traditional linear polymers (Tomalia, 2009). Generally, their constructions consist of branched of branches emanating from a core, along with a well-defined number of active groups on their surface area.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

“…Their unique structural features hold out promise of many applications in the fields of nanoelectronics and sensors, or they can be used as carriers of active substances, drugs, antiprion agents, insulating materials, and transfecting agents (Cloninger, 2002;Klajnernt et al, 2006a,b;Woo-Dong et al, 2009;Svenson, 2009). The dendritic macromolecular structure consists of a central core, branching units and terminal functional groups which can be modified (Tomalia, 2009). …”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Demetzos¹,

Pippa²

2013

Drug Delivery

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Significant progress has been made in nanoscale drugs and delivery systems employing diverse chemical formulations to facilitate the rate of drug delivery and to improve its pharmacokinetics. Biocompatible nanomaterials have been used as biological markers, contrast agents for imaging, healthcare products, pharmaceuticals, drug-delivery systems as well as in detection, diagnosis and treatment of various types of diseases. The classification of drug delivery nanosystems (DDnSs) is a crucial issue and fundamental efforts on this subject are missing from the literature. This article deals with the classification of DDnSs with a modulatory controlled release profile (MCR) denoted as modulatory controlled release nanosystems (MCRnSs). Conventional (c) and advanced (a) DDnSs are denoted by the acronyms cDDnSs and aDDnSs, and can be composed of a single or more than one biomaterials, respectively. The classification was based on their characteristics such as: surface functionality (f), the nature of biomaterials used and the kind of interactions between biomaterials. The aDDnSs can be classified as hybridic (Hy-) or chimeric (Chi-) based on the nature -same or different respectively -of biomaterials and inorganic materials used. The nature of the elements used for producing advanced biomaterials is of great importance and medicinal chemistry contributes effectively to the production of aDDnSs.

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“…Due to their precise architecture, dendrimers possess an advantage over other generally polydisperse nanoparticles and this allows for greater control over their pharmacodynamic profile, while as vehicles for drug delivery they can be used either for encapsulation of bioactive compounds or for their covalent or non-covalent attachment at the periphery (Esfand and Tomalia, 2001;DeMattei et al, 2004;Demetzos, 2006;Chauhan et al, 2009;Tomalia et al, 2007Tomalia et al, , 2009Menjoge et al, 2010). Cheng et al (2008) pointed out that dendrimers have successfully proved themselves as useful additives in different routes of drug administration (intravenous, oral, transdermal, and ocular delivery systems) because they can render greater water-solubility and bioavailability to drugs.…”

Section: Introductionmentioning

confidence: 99%

Advanced nanocarriers for an antitumor peptide

Pippa

Pispas

Demetzos³

et al. 2013

J Nanopart Res

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In this work, tigapotide (PCK3145) was incorporated into novel nanocarriers based on polymeric, lipidic and dendrimeric components, in order to maximize the advantages of the drug delivery process and possibly its biological properties. PCK3145 was incorporated into lipidic nanocarriers composed of Eggphosphatidylcholine (EggPC and finally into dendrimeric structures (i.e. PAMAM G4) . Light scattering techniques are used in order to examine the size, the size distribution and the z-potential of the nanocarriers in aqueous and biological media. Fluorescence spectroscopy was utilized in an attempt to extract information on the internal nanostructure and microenvironment of polyelectrolyte/PCK3145 aggregates. Therefore, these studies could be a rational roadmap for producing various effective nanocarriers in order to ameliorate the pharmacokinetic behavior and safety issues of antitumor and anticancer biomolecules.

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In Quest of a Systematic Framework for Unifying and Defining Nanoscience

Abstract: This article proposes a systematic framework for unifying and

Cited by 35 publications

References 188 publications

Multi-Target Inhibition of Cancer Cell Growth by SiRNA Cocktails and 5-Fluorouracil Using Effective Piperidine-Terminated Phosphorus Dendrimers

Multi-Target Inhibition of Cancer Cell Growth by SiRNA Cocktails and 5-Fluorouracil Using Effective Piperidine-Terminated Phosphorus Dendrimers

Advanced drug delivery nanosystems (aDDnSs): a mini-review

Advanced nanocarriers for an antitumor peptide

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