In pursuit of the ideal antifungal agent for Candida infections: high-throughput screening of small molecules

Wong, Sarah Sze Wah; Samaranayake, LP; Seneviratne, Chaminda Jayampath

doi:10.1016/j.drudis.2014.06.009

Cited by 51 publications

(37 citation statements)

References 145 publications

(160 reference statements)

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“…10,11 Thus, an ideal antifungal agent should have no toxicity or reduced toxicity to human cells. 12 From this perspective, medicinal plants represent a vast source of active compounds, with potential for the development of new and effective pharmaceutical forms.…”

Section: Introductionmentioning

confidence: 99%

Anadenanthera Colubrina vell Brenan: anti-Candida and antibiofilm activities, toxicity and therapeutical action

et al. 2019

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We evaluated the antifungal and antibiofilm potential of the hydroalcoholic extract of bark from Anadenanthera colubrina (vell.) Brenan, known as Angico, against Candida spp. Antifungal activity was evaluated using the microdilution technique through the Minimum Inhibitory and Fungicide Concentrations (MIC and MFC). The antibiofilm potential was tested in mature biofilms formed by Candida species and analyzed through the counting of CFU/mL and scanning electron micrograph (SEM). In vivo toxicity and therapeutic action was evaluated in the Galleria mellonella model. The treatment with the extract, in low doses, was able to reduce the growth of planktonic cells of Candida species. MIC values range between 19.5 and 39 µg/mL and MFC values range between 79 and 625 µg/mL. In addition was able to reduce the number of CFU/mL in biofilms and to cause structural alteration and cellular destruction, observed via SEM. A. colubrina showed low toxicity in the in vivo assay, having not affected the viability of the larvae at doses below 100mg/kg and high potential in the treatment of C. albicans infection. Considering its high antifungal potential, its low toxicity and potential to treatment of infections in in vivo model, A. colubrina extract is a strong candidate for development of a new agent for the treatment of oral candidiasis.

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Section: Introductionmentioning

confidence: 99%

Anadenanthera Colubrina vell Brenan: anti-Candida and antibiofilm activities, toxicity and therapeutical action

et al. 2019

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“…Co‐infections in HIV immunocompromised patients bring a new therapeutic challenge . Besides, the current arsenal of antifungal drugs, for example, azole drugs and amphotericin B, is limited and many of them show high toxicity for prolonged treatment, which demand the search for new antifungal compounds . Natural products continue to represent an endless source of opportunities in the discovery or design of new compounds with exclusive structural patterns …”

Section: Introductionmentioning

confidence: 99%

Synthesis, activity, and docking studies of eugenol‐based glucosides as new agents against Candida sp.

et al. 2018

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Seventeen new synthetic derivatives of eugenol (6, 8-15 and 8'-15') were planned following literature reports on antifungal activities of nitroeugenol and eugenol glucoside. The anti-Candida activity of these compounds was investigated by in vitro assay, and the cytotoxicity evaluation was performed with the most active compounds. The peracetylated glucosides presented better biological results than their hydroxylated analogues. The glucoside 11, a 4-nitrobenzamide, showed the best potency (MIC range 11.0-151.84 μm), the wider spectrum of action, and overall the best selectivity indexes, especially against C. tropicalis (~30) and C. krusei (~15). To investigate its possible mechanism of action, glucoside 11 was subjected to molecular docking studies with Candida sp. enzymes involved in ergosterol biosynthesis. Results have shown that the peracetyl glucosyl moiety and the 4-nitrobenzamide group in 11 are effectively involved in its high affinity with the active site of squalene epoxidase.

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“…Candida infections created a great burden on the public healthcare sector and this situation has gone worse by various epidemiological changes. The difficulties associated with the management of Candida infections necessitate the discovery of new antifungal agents 21,22 .…”

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds of Cold-pressed Thyme (<i>Thymus vulgaris</i>) Oil with Antioxidant and Antimicrobial Properties

et al. 2016

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In pursuit of the ideal antifungal agent for Candida infections: high-throughput screening of small molecules

Cited by 51 publications

References 145 publications

Anadenanthera Colubrina vell Brenan: anti-Candida and antibiofilm activities, toxicity and therapeutical action

Anadenanthera Colubrina vell Brenan: anti-Candida and antibiofilm activities, toxicity and therapeutical action

Synthesis, activity, and docking studies of eugenol‐based glucosides as new agents against Candida sp.

Bioactive Compounds of Cold-pressed Thyme (<i>Thymus vulgaris</i>) Oil with Antioxidant and Antimicrobial Properties

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