In patients with liver cirrhosis, proinflammatory interleukins correlate with health-related quality of life irrespective of minimal hepatic encephalopathy

Koziarska, Dorota; Milkiewicz, Małgorzata; Naprawa, Grzegorz; Nowacki, Przemysław; Hartleb, Marek; Milkiewicz, Piotr

doi:10.1097/meg.0b013e328365a447

Cited by 14 publications

(11 citation statements)

References 16 publications

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“…Moreover, the presence of inflammatory factors such as chemokines could suggest that inflammation plays an important role in the pathogenesis of portal hypertensive encephalopathy in rats [14]. This is in line with correlations found between serum levels of proinflammatory interleukins and physically-related general health and mental abilities in the pathogenesis of patients with MHE [15].…”

supporting

confidence: 57%

Main target of minimal hepatic encephalopathy: Morphophysiological, inflammatory and metabolic view

Arias

Méndez

Gómez-Lázaro

et al. 2015

Physiology & Behavior

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supporting

confidence: 57%

Main target of minimal hepatic encephalopathy: Morphophysiological, inflammatory and metabolic view

Arias

Méndez

Gómez-Lázaro

et al. 2015

Physiology & Behavior

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“…On the contrary, elevated levels of serum cytokines have been repeatedly reported in patients with chronic liver disease [ 28 , 29 ]. Previous literatures have revealed that IL-6 and IL-1β showed significant correlations with PHES score and correlate with health-related quality of life irrespective of MHE [ 30 ] Serum IL-6 and IL-18 levels are reported to be correlated with the degree of encephalopathy [ 6 , 31 ]. We also identified that higher serum IL-6 levels can be independently predictive of MHE, which may support that IL-6 had a more robust association with cognitive impairment in liver cirrhosis [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Detecting Minimal Hepatic Encephalopathy in an Endemic Country for Hepatitis B: The Role of Psychometrics and Serum IL-6

et al. 2015

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Background & AimsIt remains unknown what the prevalence of minimal hepatic encephalopathy is in Taiwan, a highly endemic country for chronic viral hepatitis infection. It is also unclear whether abnormal serum cytokine levels can be indicative of the presence of minimal hepatic encephalopathy. We aimed to standardize the tests of psychometric hepatic encephalopathy score and predictive value of proinflammatory cytokines in minimal hepatic encephalopathy in Taiwan.Methods180 healthy subjects and 94 cirrhotic patients without a history of overt hepatic encephalopathy from a tertiary center were invited to participate in this cross-sectional study. Blood sampling for determination of serum levels of interleukin 6 and 18 and tumor necrosis factor-α was performed. Based on the normogram of psychometric hepatic encephalopathy score from healthy volunteers, patients with minimal hepatic encephalopathy were identified from the cirrhotic patients using the criterion of a psychometric hepatic encephalopathy score less than −4.ResultsIn the healthy subjects, age and education were predictors of subtests of psychometric hepatic encephalopathy score. Minimal hepatic encephalopathy was identified in 27 (29%) cirrhotic patients. Serum interleukin 6 level (OR = 6.50, 95% CI = 1.64–25.76, P = 0.008) was predictive of the presence of minimal hepatic encephalopathy after multivariate analysis.ConclusionsThe psychometric hepatic encephalopathy score can be a useful tool for detecting patients with minimal hepatic encephalopathy in Taiwan and around one third of cirrhotic outpatients fulfill this diagnosis. A high serum interleukin 6 level is predictive of the presence of minimal hepatic encephalopathy.

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“…Some works have demonstrated a correlation between the serum concentration of IL-1β, IL-6, and IL-18 and the diverse clinical complications presented in patients with cirrhosis [17]. In addition, it has been observed that there is an increased expression of inflammatory cytokine genes, such as IL-1β, IL-6, IL-8, TGF-β, and IL-10 in patients with chronic liver disease, which is associated with the etiological agent of the disease [18].…”

Section: Discussionmentioning

confidence: 99%

Alterations in neutrophil extracellular traps is associated with the degree of decompensation of liver cirrhosis

Agraz‐Cibrián

Segura-Ortega

Delgado‐Rizo

et al. 2016

J Infect Dev Ctries

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Introduction: Liver cirrhosis (LC) constitutes one of the main 10 causes of death worldwide. LC has a characteristic asymptomatic compensated phase followed by a progressive decompensated phase, in which diverse complications are presented. LC patients are highly prone to bacterial infections. The neutrophils in these patients present defects in the production of oxygen radicals, which are essential for bacteria elimination as in the activation of neutrophil extracellular traps (NETs). The main objective of this work was to determine the NETs and neutrophil activation markers in LC patients. Methodology: Neutrophil purification was done with Ficoll Histopaque from a sample of the peripheral blood of patients with compensated and decompensated LC. Neutrophils were activated with Phorbol 12-myristate 13-acetate to evaluate the release of NETs by means of fluorescence microscopy and fluorometry, while expression of activation markers (CD69, CD80, perforin, and CAP-18) was evaluated by flow cytometry. Results: A significant decrease in the release capability of NETs was observed as the level of LC in the patient increased. When comparing serum levels in inflammatory cytokines among the different study groups, significant differences were observed. No significant differences were detected on neutrophil activation markers; nevertheless, there was a correlation between diminution of CD69 and CD80 expression in decompensated patients. Conclusions: We demonstrated that LC patients with neutrophil extracellular trap release deficiencies could have an increased rate of complications.

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In patients with liver cirrhosis, proinflammatory interleukins correlate with health-related quality of life irrespective of minimal hepatic encephalopathy

Abstract: This study shows that chronic inflammation plays a role in impaired HRQL in patients with cirrhosis irrespective of minimal HE.

Cited by 14 publications

References 16 publications

Main target of minimal hepatic encephalopathy: Morphophysiological, inflammatory and metabolic view

Main target of minimal hepatic encephalopathy: Morphophysiological, inflammatory and metabolic view

Detecting Minimal Hepatic Encephalopathy in an Endemic Country for Hepatitis B: The Role of Psychometrics and Serum IL-6

Alterations in neutrophil extracellular traps is associated with the degree of decompensation of liver cirrhosis

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