In patients suffering from idiopathic central serous chorioretinopathy, anxiety scores are higher than in healthy controls, but do not vary according to sex or repeated central serous chorioretinopathy

Bazzazi, Nooshin; Ahmadpanah, Mohammad; Akbarzadeh, Siamak; Seifrabiei, Mohammad Ali; Holsboer‐Trachsler, Edith; Brand, Serge

doi:10.2147/ndt.s83216

Cited by 17 publications

(14 citation statements)

References 17 publications

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“…In certain circumstances, such as a relapsing eye disease accompanied by stressful life events, anxiety might predispose patients to the chronic state of the disease. Anxiety is thought to be an essential feature of CSC [ 6 8 30 ], and further research on the role of anxiety in the development or progression of CSC might be needed.…”

Section: Discussionmentioning

confidence: 99%

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Association of Central Serous Chorioretinopathy with Psychosocial Factors is Dependent on Its Phase and Subtype

Kim

Woo

Park

et al. 2018

Korean J Ophthalmol

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PurposeTo analyze the psychosocial factors associated with central serous chorioretinopathy (CSC) according to its phases and subtypes and to correlate the factors with the extent of choroidal hyperpermeability.MethodsAge- and sex-matched CSC patients and controls (n = 37 in each group) were enrolled, and their psychosocial factors were compared. CSC was divided into two phases (active and inactive), and active CSC was further divided into two subtypes (acute and chronic). The correlations between the size of the hyperpermeable choroidal lesion identified on indocyanine green angiography and psychosocial factors were examined.ResultsActive CSC patients experienced more stressful events (p = 0.030), were more depressive (p = 0.037), and felt less emotional (p = 0.014) and informational (p = 0.014) support than the matched controls, whereas inactive CSC patients were comparable to the matched controls in all psychosocial factors. Among the active CSC patients, acute patients were more depressive (p = 0.029), while chronic patients experienced more stressful events (p = 0.024) than their matched controls. The size of the hyperpermeable choroidal lesion was correlated with the severity of depression in acute patients.ConclusionsAssociation of CSC with psychosocial factors was dependent on the phase and subtype of CSC. Psychosocial factors were associated with CSC in the active phase, and severity of depression was correlated with the size of the choroidal pathology in acute active CSC. Further prospective studies to investigate if psychosocial factors can trigger CSC are warranted.

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Section: Discussionmentioning

confidence: 99%

“…CSC is approximately six times more prevalent in men than in women [ 1 2 ]. Although the exact pathophysiology of CSC is yet to be determined, CSC is known to be related to personality (i.e., type A), anxiety, and stress [ 3 4 5 6 7 8 ], and stress-induced hypercortisolism may contribute to the development of CSC [ 9 ].…”

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confidence: 99%

Association of Central Serous Chorioretinopathy with Psychosocial Factors is Dependent on Its Phase and Subtype

Kim

Woo

Park

et al. 2018

Korean J Ophthalmol

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“…CSC is known to be related to anxiety and stress [ 36 , 39 ], and stress-induced hypercortisolism may contribute to the development of CSC [ 22 , 38 , 87 ]. Subjective stress perception has already been considered to be an important component of maladaptive personality traits, as well as psychosomatic comorbidity.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with CSC revealed a higher tendency to present schizophrenia, hysteria, depression, psychopathic deviance, hypochondriasis, higher levels of frustration and anticipatory anxiety than control groups [ 34 , 35 ]. In addition, higher anxiety scores were also observed in Iranian patients with CSC [ 36 ].…”

Section: Introductionmentioning

confidence: 99%

Psychological Profile and Distinct Salivary Cortisol Awake Response (CAR) in Two Different Study Populations with Obstructive Sleep Apnea (OSA) and Central Serous Chorioretinopathy (CSC)

Scarinci

Patacchioli

Ghiciuc

et al. 2020

JCM

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Obstructive sleep apnea (OSA) and central serous chorioretinopathy (CSC) are in terms of nosography different pathologies, however they share a stress-related physio-pathogenetic component, not yet explored in depth. Therefore, the aim of the present study was to ascertain whether OSA and CSC share a common profile, specifically in cortisol production focusing on the cortisol awake response (CAR), the area under curve (AUCCAR) and the SLOPECAR compared with healthy matched controls. Furthermore, standardized self-administered questionnaires were used to identify mental health status related to depression, anxiety and subjective stress perception levels in the study populations. The results showed hypothalamus-pituitary-adrenal (HPA) axis activity anomalies, represented by a flattening CAR in the OSA group and a statistically significant increase in cortisol production in CSC patients at awakening. This disarrangement of the HPA axis activity associated with elevated distress and mental health scores, and its presence in both patients with OSA and patients with CSC, might represent the shared path explaining the stress-related component in these diseases. Further research is needed to investigate the psycho-neuro-endocrinological aspects of OSA and CSC to determine whether psychoeducation on effective stress coping strategies might be of value in improving the quality of life of OSA and CSC patients.

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“…The reported incidence of the disease is approximately 9.9 cases per 100,000 men and 1.7 per 100,000 women, showing an increased prevalence in men (almost six times higher) as compared with women [ 3 ]. Several risk factors have been associated with the pathogenesis of CSC; in particular, psychosocial stressors, a type A personality, glucocorticosteroid use, trait anxiety, endogenous hypercortisolism and pregnancy have been shown to display important roles in this regard [ 2 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Current Pharmacological Treatment Options for Central Serous Chorioretinopathy: A Review

et al. 2020

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Central serous chorioretinopathy (CSC) is a common cause of visual impairment in patients generally aged 20 to 60 and it is characterized by acute or chronic neurosensory detachments of the retina. Although CSC resolves spontaneously in most cases, in some patients it may cause permanent visual impairment in the working population; for this reason, several approaches, including photodynamic therapy (PDT), subthreshold micropulse laser treatment and oral mineralocorticoid receptor antagonists, have been studied as first-line treatment options for CSC. To date, half-dose PDT has provided the most encouraging results in this regard, supported by large, multicenter, randomized clinical trials such as the “Prospective Randomized Controlled Treatment Trial for Chronic Central Serous Chorioretinopathy” (PLACE) trial; however, the role of novel possible non-invasive treatment options is attracting interest. This review article aims to discuss the current pharmacological treatment options investigated for the management of CSC, including aspirin, ketoconazole, beta blockers, rifampicin and many others. In particular, further evidence about oral mineralocorticoid receptor antagonists, firstly seen as promising non-invasive alternatives for treating CSC, will be provided and discussed in light of the recent “Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months” (VICI) trial results, which have largely resized their role as possible first-line oral treatment options for treating CSC.

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In patients suffering from idiopathic central serous chorioretinopathy, anxiety scores are higher than in healthy controls, but do not vary according to sex or repeated central serous chorioretinopathy

Cited by 17 publications

References 17 publications

Association of Central Serous Chorioretinopathy with Psychosocial Factors is Dependent on Its Phase and Subtype

Association of Central Serous Chorioretinopathy with Psychosocial Factors is Dependent on Its Phase and Subtype

Psychological Profile and Distinct Salivary Cortisol Awake Response (CAR) in Two Different Study Populations with Obstructive Sleep Apnea (OSA) and Central Serous Chorioretinopathy (CSC)

Current Pharmacological Treatment Options for Central Serous Chorioretinopathy: A Review

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