In-patient versus in-vitro degradation of P(L/Dl)LA and PLGA

Segmental stability of resorbable P(L/DL)LA-TMC osteosynthesis versus titanium miniplates in orthognatic surgery

“…other authors (Landes and Ballon, 2006a, b;Landes et al, 2006;Proffit et al, 2007). Anterior positioning of the mandible is a movement with generally high stability.…”

Polylactic acid fibre-reinforced polycaprolactone scaffolds for bone tissue engineering

“…In semicrystalline polymers degradation starts in the amorphous part, since water can enter more easily into these domains [44] increasing the proportion of crystallised regions. Furthermore, the hydrolytic attack on the ester backbone decreases the polymeric chain length with the formation of short oligomers, more mobile, which tend to recrystallize [45]. In PBS, SBF and cell culture medium, structural rearrangements appeared irrelevant (Fig.…”

Creep loading during degradation attenuates mechanical property loss in PLGA

“…(1)] was measured by subtracting the area under the crystallization exotherm (H crystal ) from the area of the melt endotherm (H melt ) and dividing the difference by the energy required to melt 100% crystalline poly-L-lactide (i.e., 93.1 J/g 28 ). This value for the reference heat of fusion was applied to PLGA crystallinity calculations as done previously 18,26 due to the high degree of L-lactide in the polymer and a lack of data for the reference heat of fusion for all copolymer architectures.…”

“…[15][16][17] While initially developed for in vivo applications with low magnitudes of mechanical loading (such as sutures), interest is increasing for the use of absorbable polymers in structural applications and environments with moderate to high loads. Examples include craniofacial applications, 18,19 ligament reconstruction or repair, [20][21][22] tissue engineered scaffolds, 23 and cardiovascular stents. 24 While the duty cycle of loading on absorbable medical devices will vary with the implantation site, some combination of static and cyclic loading is likely to be present on many of these emerging devices.…”