In New-onset Insulin-dependent Diabetic Patients the Presence of Anti-thyroid Peroxidase Antibodies is Associated with Islet Cell Autoimmunity and the High Risk Haplotype HLA DQA1*0301-DQB1*0302

Abrams, Pamela; Leeuw, I. De; Vertommen, J.

doi:10.1002/(sici)1096-9136(199605)13:5<415::aid-dia96>3.0.co;2-x

Cited by 29 publications

(21 citation statements)

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“…Genetic susceptibility of autoantibody formation associated with ATD and type 1 diabetes mellitus has been described in the literature (12)(13)(14)(15); however, there is still debate about the situation in the Chinese population (7,(16)(17)(18). In the present study, we aimed to determine the frequency and titers of anti-TPO in Taiwanese patients with type 1 diabetes mellitus, and to compare the frequency of anti-TPO in the presence or absence of anti-GAD.…”

Section: Introductionsupporting

confidence: 74%

“…As for the Chinese population, Tsai and Lee (7) and Chuang et al (8) reported that 22% and 27.7% respectively of type 1 diabetic patients were positive for AMA, while Wong reported an absence of thyroid autoimmunity in Chinese children with type 1 diabetes mellitus (17). Moreover, 10% to 24% of type 1 diabetic patients who were clinically euthyroid have been reported to be positive for anti-TPO (14,15,29). From the sera of 243 type 1 diabetic patients in the present study, 53 (21.8%) were positive for anti-TPO.…”

Section: Discussionmentioning

confidence: 95%

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Autoantibodies to thyroid peroxidase in patients with type 1 diabetes in Taiwan

Chang

Huang²,

Chuang³

1998

European Journal of Endocrinology

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Objective: Type 1 diabetes mellitus is frequently associated with autoimmune thyroid disease (ATD). Genetic susceptibility to autoantibody formation in association with ATD and type 1 diabetes mellitus has been described with varying frequencies, but there is still debate about the situation in the Chinese population. We have, therefore, investigated the prevalence of anti-thyroid peroxidase (anti-TPO) in type 1 diabetic patients, and compared the effect of anti-glutamate decarboxylase (anti-GAD) on the thyroid autoimmunity in patients with type 1 diabetes mellitus in Taiwan. Subjects and methods: Two hundred and forty-three subjects with type 1 diabetes mellitus and seventy unrelated normal controls were recruited for the detection of anti-TPO. Two hundred and seventeen sera from two hundred and forty-three type 1 diabetic patients were tested for anti-GAD. RIA and immunoprecipitation were used for anti-TPO and anti-GAD detection respectively. Results: The intra-assay and interassay coefficients of variation of anti-TPO detected by the RIA method ranged from 5.5% to 11.1%. Among 243 type 1 diabetic patients, 53 (21.8%) were positive for anti-TPO. Compared with those without thyroid autoimmunity, there was a female preponderance for the type 1 diabetic patients with thyroid autoimmunity (female:male, 99:91 vs 37:16 respectively). Among the type 1 diabetic patients with thyroid autoimmunity, anti-TPO tended to occur in those of older age or with long-standing disease. The frequency of anti-GAD was 45.6% (99 of 217), without gender preponderance (males:females, 18.0% vs 27.6%). Compared with those with negative anti-GAD, no significant difference of anti-TPO positivity for the type 1 diabetic patients with positive anti-GAD was found. Conclusion: Our data indicated that the RIA method for anti-TPO detection is sensitive and precise for routine clinical use. The presence of anti-TPO in 21.8% of our type 1 diabetic patients confirmed the strong association of ATD and type 1 diabetes mellitus without ethnic differences. The absence of correlation between anti-TPO and anti-GAD in our type 1 diabetic patients suggested genetic heterogeneity in the role of autoimmunity of type 1 diabetes mellitus and ATD among races.

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Section: Introductionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 95%

Autoantibodies to thyroid peroxidase in patients with type 1 diabetes in Taiwan

Chang

Huang²,

Chuang³

1998

European Journal of Endocrinology

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“…Thyroid peroxidase (cut-off > 100 U/ml), thyroid-stimulating hormone (TSH) receptor (cut-off > 9 U/l), and anti-intrinsic factor antibodies (cut-off ratio ((ct/min in patient serum)/(ct/min in normal serum)) > 1 . 1) were measured by radioimmunoassay and antigastric parietal cell antibodies (cutoff titre > 1:20) by indirect immunofluorescence assay [35].…”

Section: Autoantibody Assaysmentioning

confidence: 99%

CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers

Auwera

Vandewalle

Schuit

et al. 1997

Clinical and Experimental Immunology

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SUMMARYApart from genes in the HLA complex (IDDM1) and the variable number of tandem repeats in the 5 0 region of the insulin gene (INS VNTR, IDDM2), several other loci have been proposed to contribute to IDDM susceptibility. Recently, linkage and association have been shown between the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) gene on chromosome 2q and IDDM. In a registry-based group of 525 recent-onset IDDM patients < 40 years old we investigated the possible interactions of a CTLA-4 gene A-to-G transition polymorphism with age at clinical disease onset and with the presence or absence of established genetic (HLA-DQ, INS VNTR) and immune disease markers (autoantibodies against islet cell cytoplasm (ICA); insulin (IAA); glutamate decarboxylase (GAD65-Ab); IA-2 protein tyrosine phosphatase (IA-2-Ab)) determined within the first week of insulin treatment. In new-onset IDDM patients, G-allele-containing CTLA-4 genotypes (relative risk (RR) ¼ 1 . 5; 95% confidence interval (CI) ¼ 1 . 2-2 . 0; P < 0 . 005) were not preferentially associated with age at clinical presentation or with the presence of other genetic (HLA-DR3 or DR4 alleles; HLA-DQA1*0301-DQB1*0302 and/or DQA1*0501-DQB1*0201 risk haplotypes; INS VNTR I/I risk genotype) or immune (ICA, IAA, IA-2-Ab, GAD65-Ab) markers of diabetes. For 151 patients, thyrogastric autoantibodies (anti-thyroid peroxidase, anti-thyroid-stimulating hormone (TSH) receptor, anti-parietal cell, anti-intrinsic factor) were determined, but association between CTLA-4 risk genotypes and markers of polyendocrine autoimmunity could not be demonstrated before or after stratification for HLA-or INS-linked risk. In conclusion, the presence of a G-containing CTLA-4 genotype confers a moderate but significant RR for IDDM that is independent of age and genetic or immune disease markers.

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“…Thyroid autoantibodies are more common in people with diabetes than in the general population; prevalences from 15% to 31% have been reported in type 1 diabetes mellitus (T1DM) (6)(7)(8)(9)(10)(11)(12)(13)(14)(15), and of 15% in type 2 diabetes mellitus (T2DM) (11). The presence of thyroid autoantibodies at the time of diagnosis of T1DM also increases the likelihood of concurrent thyroid dysfunction (6,8,9,14).…”

Section: Introductionmentioning

confidence: 99%