In-line monitoring of Ibuprofen during and after tablet compression using near-infrared spectroscopy

Process Analytical Technology Tools for Monitoring Pharmaceutical Unit Operations: A Control Strategy for Continuous Process Verification

“…In-line monitoring, as well as offline monitoring, was performed using NIRS, and the in-line spectrum of the compressed tablet was quantitatively evaluated by PLS analysis. The PLS-predicted content of the tablet was in good agreement with the corresponding content obtained by the UV-VIS assay [ 272 ]. The Li et al study is an example of PAT using Raman spectroscopy, another spectral technology tool in the tablet compression process.…”

“…By contrast, NIRS, Raman spectroscopy, and chemical imaging are nondestructive techniques that provide the simultaneous measurement of chemical and physical properties during the tableting process. In this manner, the spectrum of compressed tablets, which is collected via spectroscopy or imaging, is affected by small changes in tablet and surface shape (such as rectangular or concave) and tablet hardness [ 272 ].…”

A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing

“…Furthermore, numerous studies have investigated the potential use of NIR spectroscopy for the analysis of dissolution rate, coating, density, tensile strength, hardness, porosity, particle size, compaction force and detection of counterfeit tablets and degradation products in intact tablets [192,244]. Dalvi et al reported the suitability of NIR spectroscopy to monitor the concentration of ibuprofen both inside the feed frame of tablet press and in compressed tablets [207]. Avila et al used MEMSbased NIR sensor to monitor the moisture content during drying of granules in a fluidized bed dryer (Figure 5A) [245].…”

Real-time monitoring of the column chromatographic process of Phellodendri Chinensis Cortex part II: multivariate statistical process control based on near-infrared spectroscopy

“…Besides the most common off-line analysis, several other options comprising on-line, at-line and remote analysis can be realized by installing an optical fiber, flow cell, or wireless transmission device on the spectrometer. [19][20][21] However, most of the articles that have been published to date focus on the application of quantitative monitoring. Sulub et al realized the monitoring of the blending process by developing an excellent quantitative calibration model.…”