In-line FBRM Monitoring of Particle Size in Dilute Agitated Suspensions

Barrett, Peter; Glennon, Brian

doi:10.1002/(sici)1521-4117(199910)16:5<207::aid-ppsc207>3.0.co;2-u

Cited by 131 publications

(78 citation statements)

References 9 publications

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“…The focal point of the probe tip was positioned at 0.02 mm from the sapphire window, as recommended by the equipment manual , to reduce the effects caused by differences of the refractive indices between the sapphire window and the heterogeneous phase, reducing the background noise and diminishing the sensitivity of the measurement to the surface roughness of the particle. This is consistent with the assumption that the measured chord lengths are the result of random traverses of the projected particle area, and are not weighted in favor of the smaller end of the CLD . For best results, the probe tip was located in a region of high turbulence, positioned 2.0 cm above the impeller, as already applied in the literature of the FBRM .…”

Section: Methodssupporting

confidence: 83%

On‐line monitoring of chord distributions in liquid–liquid dispersions and suspension polymerizations by using the focused beam reflectance measurement technique

Poblete

Castor

Nele

et al. 2015

Polymer Engineering & Sci

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The on-line monitoring of the droplet/particle size distributions is very important to ensure the quality and applicability of various products in heterogeneous systems. For this reason, the main objective of the present work was to study the usage of the focused beam reflectance measurement (FBRM) technique for monitoring of liquid-liquid dispersions (styrene dispersion in aqueous solutions) and suspension polymerization of styrene. To do better understand the FBRM technique in these systems, the effects of surfactant concentrations, agitation speed and ambient light were evaluated during the in-line monitoring of average chord lengths and chord-length distributions (CLD) at different operation conditions in batch experiments. In addition, a preliminary investigation of the optimal probe position was conducted in the polymerization experiments. It is shown that the FBRM technique is sensitive to variations of particle sizes in the characteristic ranges of particle diameters of typical styrene suspension polymerizations, being useful for monitoring and also control applications that require the on-line characterization of CLD in real time in liquid-liquid dispersions and polymerization systems. POLYM. ENG. SCI., 56:309-318, 2016.

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Section: Methodssupporting

confidence: 83%

On‐line monitoring of chord distributions in liquid–liquid dispersions and suspension polymerizations by using the focused beam reflectance measurement technique

Poblete

Castor

Nele

et al. 2015

Polymer Engineering & Sci

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“…FBRM is a desirable measurement technology that conducts in situ particle characterization. Its detection principle is discussed in details in scientific literature 9–10. FBRM measures a chord length (and its distribution) of the particles.…”

Section: Resultsmentioning

confidence: 99%

Characterization and Optimization of AMG 517 Supersaturatable Self‐Emulsifying Drug Delivery System (S‐SEDDS) for Improved Oral Absorption

Gao

Akrami

Álvarez

et al. 2009

Journal of Pharmaceutical Sciences

142

107

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“…30 The iC FBRM software (version 4.4) coupled to the FBRM hardware acquires the data and allows for the data analysis.…”

Section: Inline Particle Detection-fbrmmentioning

confidence: 99%

Application of inline imaging for monitoring crystallization process in a continuous oscillatory baffled crystallizer

Kacker

Maaß²,

Emmerich³

et al. 2018

AIChE Journal

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In this study, an in situ imaging system has been analysed to characterize the crystal size, the shape and the number of particles during a continuous crystallization process in a Continuous Oscillatory Baffled Crystallizer (COBC). Two image analysis approaches were examined for particle characterization in the suspension containing both small nuclei and larger grown crystals (nonspherical and irregular in shape). The pattern matching approach, in which the particles are approximated to be spherical, did result in an overestimation of the size. Alternatively, a segmentation‐based algorithm resulted in reliable crystal size and shape characteristics. The laser diffraction analysis in comparison to the image analysis overestimated the particle sizes due to the agglomeration of particles upon filtration and drying. The trend in the particle counts during the start of crystallization process, including nucleation, determined by the image analysis probe was comparable with the one measured by FBRM, highlighting the potential of in situ imaging for process monitoring. © 2018 American Institute of Chemical Engineers AIChE J, 64: 2450–2461, 2018

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In-line FBRM Monitoring of Particle Size in Dilute Agitated Suspensions

Cited by 131 publications

References 9 publications

On‐line monitoring of chord distributions in liquid–liquid dispersions and suspension polymerizations by using the focused beam reflectance measurement technique

On‐line monitoring of chord distributions in liquid–liquid dispersions and suspension polymerizations by using the focused beam reflectance measurement technique

Characterization and Optimization of AMG 517 Supersaturatable Self‐Emulsifying Drug Delivery System (S‐SEDDS) for Improved Oral Absorption

Application of inline imaging for monitoring crystallization process in a continuous oscillatory baffled crystallizer

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