In‐hospital mortality in SARS‐CoV‐2 stratified by serum 25‐hydroxy‐vitamin D levels: A retrospective study

Al‐Jarallah, Mohammed; Rajan, Rajesh; Dashti, Raja; Saber, Ahmad Al; Pan, Jiazhu; Kobalava, Zh. D.; Abdelnaby, Hassan; Aboelhassan, Wael; Almutairi, Farah; Abdullah, Mohammed; Alotaibi, Naser; Saleh, Marwa; Nasrallah, Noor Al; Al‐Bader, Bader; Malhas, Haya; Ramadhan, Maryam; Hamza, Mahdy; Brady, Peter A.; Al‐Zakwani, Ibrahim; Alroomi, Moudhi

doi:10.1002/jmv.27133

Cited by 19 publications

(11 citation statements)

References 25 publications

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“…The study was conducted between February 26, 2020 and September 8, 2020. The data were collected from the electronic medical records of two hospitals in Kuwait: Jaber Al-Ahmed Hospital and Al Adan General Hospital [ 17 , 18 , 19 ]. During the data entry stage, an electronic case report form was used.…”

Section: Methodsmentioning

confidence: 99%

Risk Factors for Mortality in Patients with COVID-19: The Kuwait Experience

et al. 2022

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Objectives: To describe the baseline characteristics and evaluate the risk factors for in-hospital mortality in patients admitted to hospitals with coronavirus disease (COVID-19) in Kuwait. Subjects and Methods: This retrospective cohort analysed data of patients admitted to two hospitals in Kuwait with COVID-19. The outcome was assessed by using multivariable analysis of factors affecting survival and mortality. Results: In the 962 patients, the case fatality ratio in this study was 9.04%. The mean age of non-survivors was 63.5 ± 14.8 years, and most deaths occurred in males (80.5%). For the whole sample, source of transmission was significantly related to mortality and the median duration of in-hospital stay was 15 (interquartile range: 2–52) days. In patients with high oxygen requirements, the case fatality rate was 96.6%. Multivariable analysis identified age, hypertension, cardiovascular disease (CVD), and dyspnoea on presentation as independent risk factors for COVID-19 mortality. Conclusions: The mortality rate was higher in older patients with comorbidities such as hypertension and CVD. Early recognition of high-risk patients may help to improve care and reduce mortality.

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Section: Methodsmentioning

confidence: 99%

Risk Factors for Mortality in Patients with COVID-19: The Kuwait Experience

et al. 2022

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“…The results of a pilot study in Spain suggest that vitamin D supplementation may reduce disease severity 52 . In contrast, a retrospective cohort study of 231 patients found that serum calcidiol levels were not significant in predicting mortality in patients with SARS-CoV-2 37 . Another cohort study suggested a similar risk of mortality in COVID-19, independent of vitamin D concentration 38 .…”

Section: Discussionmentioning

confidence: 85%

The ratio of serum LL-37 levels to blood leucocyte count correlates with COVID-19 severity

Keutmann

Hermes

Meinberger

et al. 2022

Sci Rep

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Beneficial effects of vitamin D on COVID-19 progression have been discussed in several studies. Vitamin D stimulates the expression of the antimicrobial peptide LL-37, and evidence shows that LL-37 can antagonize SARS-CoV-2. Therefore, we investigated the association between LL-37 and vitamin D serum levels and the severity of COVID-19. To this end, 78 COVID-19 patients were divided into 5 groups according to disease severity. We determined serum levels of LL-37, vitamin D, and routine laboratory parameters. We demonstrated a correlation of CRP, IL-6, PCT, leukocyte count, and LDH with the severity of COVID-19. Our study did not demonstrate a direct relationship between serum levels of LL-37 and vitamin D and the severity of COVID-19. LL-37 is produced by granulocytes and released at the site of inflammation. Therefore, the analysis of LL-37 in broncho-alvelolar lavage rather than in patient serum seems critical. However, since LL-37 is produced by granulocytes, we determined serum LL-37 levels as a function of leukocyte count. The LL-37/leukocyte count ratio correlates highly significantly inversely proportional with COVID-19 severity. Our results indicate that the LL-37/leukocyte count ratio could be used to assess the risk of COVID-19 progression as early as hospital admission.

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“…All the data were obtained from electronic medical records from two tertiary care hospitals in Kuwait: Jaber Al‐Ahmed Hospital and Al Adan General Hospital. 11 , 12 , 13 An electronic case‐record form (CRF) was used for data entry.…”

Section: Methodsmentioning

confidence: 99%

In‐hospital mortality in SARS‐CoV‐2 stratified by gamma‐glutamyl transferase levels

Alroomi

Rajan

Alsaber

et al. 2022

Clinical Laboratory Analysis

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Background: This study investigates in-hospital mortality amongst patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its relation to serum levels of gamma-glutamyl transferase (GGT). Methods: Patients were stratified according to serum levels of gamma-glutamyl transferase (GGT) (GGT<50 IU/L or GGT≥50 IU/L).Results: A total of 802 participants were considered, amongst whom 486 had GGT<50 IU/L and a mean age of 48.1 (16.5) years, whilst 316 had GGT≥50 IU/L and a mean age of 53.8 (14.7) years. The chief sources of SARS-CoV-2 transmission were contact (366, 45.7%) and community (320, 40%). Most patients with GGT≥50 IU/L had either pneumonia (247, 78.2%) or acute respiratory distress syndrome (ARDS) (85, 26.9%), whilst those with GGT<50 IU/L had hypertension (141, 29%) or diabetes mellitus (DM) (147, 30.2%). Mortality was higher amongst patients with GGT≥50 IU/L (54, 17.1%) than amongst those with GGT<50 IU/L (29, 5.9%). More patients with GGT≥50 required high (83, 27.6%) or low (104, 34.6%) levels of oxygen, whereas most of those with GGT<50 had no requirement of oxygen (306, 71.2%). Multivariable logistic How to cite this article: Alroomi M, Rajan R, Alsaber A, et al.In-hospital mortality in SARS-CoV-2 stratified by gammaglutamyl transferase levels.

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In‐hospital mortality in SARS‐CoV‐2 stratified by serum 25‐hydroxy‐vitamin D levels: A retrospective study

Cited by 19 publications

References 25 publications

Risk Factors for Mortality in Patients with COVID-19: The Kuwait Experience

Risk Factors for Mortality in Patients with COVID-19: The Kuwait Experience

The ratio of serum LL-37 levels to blood leucocyte count correlates with COVID-19 severity

In‐hospital mortality in SARS‐CoV‐2 stratified by gamma‐glutamyl transferase levels

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