In-home mandibular repositioning during sleep using MATRx plus predicts outcome and efficacious positioning for oral appliance treatment of obstructive sleep apnea

Mosca, E.; Bruehlmann, Sabina; Zouboules, Shaelynn M.; Chiew, Alexandra E.; Westersund, Curtis; Hambrook, Dillon A.; Jahromi, Seyed Abdolali Zareian; Grosse, Joshua; Topor, Zbigniew L.; Charkhandeh, Shouresh; Remmers, John E.

doi:10.5664/jcsm.9758

Cited by 7 publications

(5 citation statements)

References 41 publications

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“…The percent improvement in AHI was 76.6% with the novel OAT device, from a mean, pre-treatment, baseline AHI of 23.9 events per hour to a mean, with treatment, residual AHI of 5.6 events per hour. This level of improvement agrees with what has been reported in other studies for precision OAT [14,[21][22][23][24]. The efficacy reported in this study is also directionally better than what has been reported for traditional oral devices [14,25,26].…”

Section: Discussionsupporting

confidence: 92%

Evaluating the Clinical Performance of a Novel, Precision Oral Appliance Therapy Medical Device Made Wholly From a Medical Grade Class VI Material for the Treatment of Obstructive Sleep Apnea

Sall,

Smith,

Desai

et al. 2023

Cureus

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The objective of this study is to evaluate the clinical performance of a novel, precision, oral appliance therapy (OAT) medical device made entirely from a US Pharmacopeia (USP) medical grade class VI qualified material for the treatment of obstructive sleep apnea (OSA). MethodsThis was a multi-center, single-arm, chart-based, retrospective study of 91 patients diagnosed with OSA, treated utilizing a novel, precision, OAT medical device. Performance criteria were overall efficacy (reduction of OSA events to less than 10 per hour); efficacy for patients with severe OSA (reduction of OSA events to less than 20 per hour and a 50% improvement); and compliance (the rate of continuation of treatment after at least a one-year follow-up, or, conversely, the rate of discontinuation of treatment due to material-related adverse events or side effects after one year). ResultsEighty-nine percent of all subjects diagnosed with all levels of OSA severity were successfully treated to an apnea hypopnea index ("AHI") < 10 events per hour. Ninety-eight percent of subjects diagnosed with mild to moderate OSA were successfully treated to an AHI < 10. Eighty percent of subjects with severe OSA, without screening or excluding subjects for airway collapse profile, were successfully treated to an AHI < 20 with a 50% improvement in AHI. After a minimum one-year follow-up period, 96% of patients were confirmed to remain in active treatment. No subjects were reported to discontinue treatment due to adverse events or side effects. ConclusionsThis novel, precision OAT medical device made from the USP Class VI qualified material demonstrated efficacy and safety for the treatment of patients with OSA.

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Section: Discussionsupporting

confidence: 92%

Evaluating the Clinical Performance of a Novel, Precision Oral Appliance Therapy Medical Device Made Wholly From a Medical Grade Class VI Material for the Treatment of Obstructive Sleep Apnea

Sall,

Smith,

Desai

et al. 2023

Cureus

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“…An early iteration of the FCMP demonstrated a sensitivity and specificity of 85 and 93% respectively for the prediction of therapeutic success, defined as an oxygen desaturation index (ODI) < 10/hr with the device in situ (Remmers et al, 2017). A subsequent iteration improved the sensitivity and specificity to 91 and 100% respectively, with 93% prediction accuracy (Mosca et al, 2022). This finding highlights the potential for future use of an autotitrating mandibular advancement device to efficiently identify the therapeutic mandibular position.…”

Section: Mas Titration Technologymentioning

confidence: 70%

Novel Technologies in the Diagnosis and Management of Sleep-disordered Breathing

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Mas Titration Technologymentioning

confidence: 81%

Innovations in mandibular advancement splint therapy for obstructive sleep apnoea

Mohammadieh

Tong²,

Chazal³

et al. 2023

Front. Sleep

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Mandibular advancement splint (MAS) therapy emerged as an effective therapy for obstructive sleep apnoea (OSA) in the mid 1990s, and is now the leading treatment alternative for OSA. Since its inception, the field has seen a suite of revisions and advances in relation to design and customisation, fabrication, titration methods, response prediction models and the integration of data collection technology. This paper reviews these current and emerging innovations in MAS therapy and their impact upon sleep apnoea management.

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In-home mandibular repositioning during sleep using MATRx plus predicts outcome and efficacious positioning for oral appliance treatment of obstructive sleep apnea

Cited by 7 publications

References 41 publications

Evaluating the Clinical Performance of a Novel, Precision Oral Appliance Therapy Medical Device Made Wholly From a Medical Grade Class VI Material for the Treatment of Obstructive Sleep Apnea

Evaluating the Clinical Performance of a Novel, Precision Oral Appliance Therapy Medical Device Made Wholly From a Medical Grade Class VI Material for the Treatment of Obstructive Sleep Apnea

Novel Technologies in the Diagnosis and Management of Sleep-disordered Breathing

Innovations in mandibular advancement splint therapy for obstructive sleep apnoea

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