In Focus: Neonicotinoid insecticides Editorial

Nauen, Ralf; Jeschke, Peter; Copping, Len

doi:10.1002/ps.1659

Cited by 67 publications

(52 citation statements)

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“…It is noted that the principal response curve analysis generated a negative weight for leafhoppers, indicating greater abundance in the insecticide treated plots. This response was statistically significant for leafhoppers ( F = 6.4, P = 0.045), with densities recorded in treated plots that were about double those in control plots…”

Section: Resultsmentioning

confidence: 96%

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Effects of clothianidin‐treated seed on the arthropod community in a mid‐Atlantic no‐till corn agroecosystem

Disque¹,

Hamby

Dubey

et al. 2018

Pest Management Science

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Clothianidin primarily influenced arthropod communities during the 4 weeks following planting, with disruptions to major natural enemy taxa, but communities showed trends toward recovery at the later corn stages. While the insecticide suppressed multiple herbivores, none were economically damaging to corn; thus, the pest suppression benefits of clothianidin observed in this study did not justify the non-target impacts. © 2018 Society of Chemical Industry.

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Section: Resultsmentioning

confidence: 96%

“…Currently, more than 90% of all corn seed in the US is coated with neonicotinoid insecticides to protect against soil and foliar arthropod pests . Widespread use of these reduced risk insecticides occurs due to their prophylactic nature, convenience, and low cost .…”

Section: Introductionmentioning

confidence: 99%

Effects of clothianidin‐treated seed on the arthropod community in a mid‐Atlantic no‐till corn agroecosystem

Disque¹,

Hamby

Dubey

et al. 2018

Pest Management Science

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“…The neonicotinoids are the fastest growing class of insecticides in the global crop protection market with annual worldwide sales of over $1.5 billion [18]. They have remained effective against M. persicae because they circumvent the resistance mechanisms that have evolved to other insecticide classes, and have so far not been compromised by the evolution of novel mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Mutation of a nicotinic acetylcholine receptor β subunit is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae

et al. 2011

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BackgroundMyzus persicae is a globally important aphid pest with a history of developing resistance to insecticides. Unusually, neonicotinoids have remained highly effective as control agents despite nearly two decades of steadily increasing use. In this study, a clone of M. persicae collected from southern France was found, for the first time, to exhibit sufficiently strong resistance to result in loss of the field effectiveness of neonicotinoids.ResultsBioassays, metabolism and gene expression studies implied the presence of two resistance mechanisms in the resistant clone, one based on enhanced detoxification by cytochrome P450 monooxygenases, and another unaffected by a synergist that inhibits detoxifying enzymes. Binding of radiolabeled imidacloprid (a neonicotinoid) to whole body membrane preparations showed that the high affinity [3H]-imidacloprid binding site present in susceptible M. persicae is lost in the resistant clone and the remaining lower affinity site is altered compared to susceptible clones. This confers a significant overall reduction in binding affinity to the neonicotinoid target: the nicotinic acetylcholine receptor (nAChR). Comparison of the nucleotide sequence of six nAChR subunit (Mpα1-5 and Mpβ1) genes from resistant and susceptible aphid clones revealed a single point mutation in the loop D region of the nAChR β1 subunit of the resistant clone, causing an arginine to threonine substitution (R81T).ConclusionPrevious studies have shown that the amino acid at this position within loop D is a key determinant of neonicotinoid binding to nAChRs and this amino acid change confers a vertebrate-like character to the insect nAChR receptor and results in reduced sensitivity to neonicotinoids. The discovery of the mutation at this position and its association with the reduced affinity of the nAChR for imidacloprid is the first example of field-evolved target-site resistance to neonicotinoid insecticides and also provides further validation of exisiting models of neonicotinoid binding and selectivity for insect nAChRs.

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“…The predominant neonicotinoids used in seed treatment formulations for grain and oilseed crops are thiamethoxam, clothianidin (a metabolite of thiamethoxam) and imidacloprid. When applied as a seed treatment, the high water solubility of neonicotinoids permits translocation via xylem flow, moving the insecticide systemically throughout the growing plant . Seed treatments have the potential to offer a more targeted and precise delivery of insecticides when compared with conventional alternatives (i.e., foliar‐applied organophosphates and pyrethroids) .…”

Section: Introductionmentioning

confidence: 99%

Assessing the value and pest management window provided by neonicotinoid seed treatments for management of soybean aphid (Aphis glycines Matsumura) in the Upper Midwestern United States

Krupke

Alford

Cullen

et al. 2017

Pest Management Science

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These data demonstrate that an IPM approach, combining scouting and foliar-applied insecticide where necessary, remains the best option for treatment of soybean aphids, both in terms of protecting the yield potential of the crop and of break-even probability for producers. Furthermore, we found that thiamethoxam concentrations in foliage are unlikely to effectively manage soybean aphids for most of the pests' activity period across the region. © 2017 Society of Chemical Industry.

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In Focus: Neonicotinoid insecticides Editorial

Cited by 67 publications

References 0 publications

Effects of clothianidin‐treated seed on the arthropod community in a mid‐Atlantic no‐till corn agroecosystem

Effects of clothianidin‐treated seed on the arthropod community in a mid‐Atlantic no‐till corn agroecosystem

Mutation of a nicotinic acetylcholine receptor β subunit is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae

Assessing the value and pest management window provided by neonicotinoid seed treatments for management of soybean aphid (Aphis glycines Matsumura) in the Upper Midwestern United States

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