In Early Axial Spondyloarthritis, Increasing Disease Activity Is Associated with Worsening of Health-related Quality of Life over Time

Abstract

To our knowledge, our data are the first to show that in a broad group of patients with early axSpA, increasing ASDAS is associated with worsening of physical HRQOL, but not mental HRQOL, over time.

Determinants of Health-Related Quality of Life in Spondyloarthritis and Rheumatoid Arthritis - Data from the COMOSPA and COMORA Studies

“…increased work productivity loss and higher ASDAS/DAS28-CRP-3v scores (higher disease activity) were associated with lower EQ5D-3 L scores (HRQoL). Similar results have been previously reported, both in SpA [25,[28][29][30] and RA patients.…”

Do Smoking and Socioeconomic Factors Influence Imaging Outcomes in Axial Spondyloarthritis? Five‐Year Data From the DESIR Cohort

“…This formed the basis for speculation on reasons behind the findings of our study. Although a rather crude dichotomy, it is one that has previously been widely accepted and used (5,27). Furthermore, smoking status was the main association of interest in our study, but information on the intensity/amount of smoking (e.g., number of pack‐years) was not available, preventing a more detailed study of smoking (and appropriate quantification) and its effects on outcomes.…”

Gender difference in ASAS HI among patients with ankylosing spondylitis

“…Given that disease activity and structual damage of the spine were the most important risk factors for poor health and function [ 45 , 47 ] and were correlated with gender (Table A in S1 Table ), we also examined whether or not disease activity measures (i.e., ESR, CRP, ASDAS-ESR, ASDAS-CRP and BASDAI) and mSASSS had potential mediation effects for the influence of gender on ASAS HI.…”

“…To our knowledge, no prior studies have investigated risk factors for the sum score of ASAS HI. Given that ASAS HI was validated to assess health and function in patients with SpA, we only considered the variables that were both shown to be risk factors for function/disability [38][39][40][41][42][43][44][45][46], health status [42], or health-related quality of life [47,48] in previous studies and available in our data as potential confounder. Therefore, potential confounders in the relationships between gender and ASAS HI include disease activity [38,40,45,[47][48][49], mSASSS [45,49], age at the index date [42], disease (symptom) duration [38,42,43,48], smoking history (never, ever/current) [39,43,46], a family history (first degree or secondary degree relatives) of AS [42,43], number of comorbidities (including hypertension, diabetes mellitus, hyperlipidemia, hepatitis B, hepatitis C, gout, coronary artery disease, stroke, periodontal disease, osteoporosis) [43,50], and the presence of any extra-spinal manifestations (i.e., uveitis, psoriasis, inflammatory bowel disease, peripheral arthritis, enthesitis, and dactylitis) [40,50].…”