Imupret® inhibits respiratory syncytial virus replication and displays in vitro and in vivo immunomodulatory properties

Herbal medicinal products in RESPIRATORY diseases – STANce of the Polish PHYTOtherapy Association – STANPHYTO RESPIRATORY II

“…the components of the combination medicine exhibit immunomodulatory, anti-inflammatory, antiviral and antimicrobial properties. In vitro studies indicate inhibition of rsV replication and modulation of immune functions [19]. Medical findings also demonstrate an increased expression of the antiviral defensins hBD-1 and ll-37 [20].…”

“…an in vitro study on a549 lung epithelial cells notes a possible suppression of airway inflammation by inhibiting il-8 and hBD-e production in epithelial cells [21]. in addition, the medicine increased phagocytosis capacity by 180%, which may enhance microbial elimination [19,22]. Moreover, the immunomodulatory effects of the medicine have been shown, and these refer to stimulation of nK cell activity by 150%, increased cytolytic activity and interferon production, as demonstrated in an in vitro study of human tonsil cells [19].…”

Antibiotic Resistance in Modern World

“…Другой пример фитотерапии -препарат BNO 1030/1035 (растительный препарат в виде капель, сиропа, таблеток, драже из коры дуба, корня алтея, листьев грецкого ореха, травы одуванчика лекарственного, тыся-челистника, хвоща и цветков ромашки; Тонзилгон) -про-демонстрировал и хорошее иммуномодулирующее дей-ствие в тестах in vitro [36], существенно ускоряя процессы фагоцитоза, активируя клетки-киллеры, увеличивая цито-литическую активность и усиливая выработку миндали-нами интерферона, и in vivo -уменьшая количество эпи-зодов ОРВИ у часто болеющих детей и облегчая течение эпизодов вирусных инфекций, протекающих с явлениями назофарингита и тонзиллита (рис. 10, 11) [37].…”

The potential of herbal extracts to inhibit SARS-CoV-2: a pilot study

“…The safety and tolerability of Imupret ® (BNO-1030) extract, containing marshmallow root, chamomile flowers, horsetail herb, walnut leaves, yarrow herb, oak bark and dandelion herb, in the treatment of acute viral tonsillitis in children was shown in a randomised clinical trial [ 8 , 12 ]. Imupret ® also showed symptomatic benefits in patients infected with Epstein-Barr virus [ 12 ] and inhibited the replication of the common respiratory pathogen respiratory syncytial virus (RSV) in cell culture and animal models [ 13 ]. Further, there is encouraging evidence for Sinupret ® extract (BNO-1016), an extract of gentian root, primrose flower, elder flower, sorrel herb and verbena herb, as an effective adjunctive treatment in acute rhinosinusitis.…”