Antibiotic Resistance in Modern World

Намазова-Баранова, Л. С.; Баранов, А. А.

doi:10.15690/pf.v14i5.1782

Cited by 32 publications

(7 citation statements)

References 16 publications

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“…Носительство патобионтов можно расценивать как дисбиоз, развивающийся на фоне нарушения колонизационной резистентности. Следовательно, применение антибиотиков с целью санации бактерионосителей лишь усугубляет дисбиоз, а также способствует формированию лекарственной устойчивости патобионтов [7,8,12]. Восстановление состава микробиоты носоглотки с помощью пробиотиков, то есть резидентных бактерий, обитающих на слизистых оболочках человека в норме, позволит проводить элиминацию патобионтов «экологически щадящим» способом [16,17].…”

Section: Discussionunclassified

Detection of meningococcus, pneumococcus, Haemophilus influenzae, and group A streptococcus DNA in pediatric adenoid bioptats

Комбарова

Бичучер

Soldatskiĭ

et al. 2020

Russian Journal of Infection and Immunity

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Meningococcal, pneumococcal, streptococcal A and Haemophilus influenzae infections are manifested in different clinical forms, ranging from bacterial carriage to generalized life-threatening conditions. However, a connection between bacterial carriage and disease development has not been fully explored. A PCR assay was performed with adenoid biopsy samples collected from 112 children after planned adenotomy to detect Neisseria meningitidis, Streptococcus pneumoniae, Streptococcus pyogenes, H. influenzae carriage. A DNA specific to at least one of the four studied microbial species was found in 104 samples (92.86%) so that: meningococcal DNA was detected in one sample (0.9%), pneumococcal — in 98 (87.5%), H. influenzae — in 19 (16.96%), and streptococcal A — in 42 (37.5%) samples. However, none of these species was found in 8 children (7.14%). A sole S. pneumoniae was detected in 54 samples (48.2%), whereas S. pyogenes — in 5 samples (4.5%). Moreover, two bacterial species were simultaneously as follows: N. meningitidis and S. pneumoniae — in 1 sample (0.9%), S. pneumoniae and H. influenzae — in 7 samples (6.3%); H. influenzae and S. pyogenes — in 1 sample (0.9%); S. pneumoniae and S. pyogenes — in 25 samples (22.3%). A triple combination consisting of S. pneumoniae, H. influenzae and S. pyogenes bacteria were detected together in 11 patients (9.8%). Meningococcal serogrouping revealed no connection with any of the 6 most common global serogroups responsible for epidemic incidence rise (A, B, C, W-135, X, Y). A clear tendency for prevalence of S. pyogenes DNA in adenoid pediatric biopsies in children diagnosed with “Adenoids and tonsils hypertrophy” vs. “Adenoids hypertrophy” was observed. It is noteworthy, a high relative prevalence of pneumococcal carriage (87.5%), found by us was of special importance. Pediatric carriers serving as a reservoir for virulent pneumococcal species pose a threat both for themselves and surrounding people. Thus, PCR-based data of adenoid biopsies may be a promising approach for future studies, as a potential to identify live viable but nonculturable bacteria in clinical specimens will contribute to a more accurate assessment of carriage rate of meningococci, pneumococci, H. influenzae and group A streptococci.

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Section: Discussionunclassified

Detection of meningococcus, pneumococcus, Haemophilus influenzae, and group A streptococcus DNA in pediatric adenoid bioptats

Комбарова

Бичучер

Soldatskiĭ

et al. 2020

Russian Journal of Infection and Immunity

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“…За последние 15 лет нерациональное использование антибиотиков не только не остановилось, но даже возросло, в связи с чем с ноября 2015 г. стали проводиться так называемые всемирные недели правильного использования антибиотиков. Согласно Глобальному плану про-филактики и борьбы с антибиотикорезистентностью [38], в 2016 г. меры в этом направлении должны приниматься на всех уровнях общества [39,40].…”

Section: Discussionunclassified

On the Prospects for Child Disability Prevention Research

Баранов

Terletskaya

2019

Vopr. sovr. pediatr.

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The presented review of the special literature data (on MEDLINE and eLIBRARY.RU databases) makes it possible to determine a number of topical issues for preventing child disability as well as trends of scientific research in this area, taking into account the causes of disability and its structure by the underlying disease. The World Health Organization has established a relentless focus on the problem of disability, including that of children, which is reflected in the continuous improvement of methods for assessing and classifying persistent disabilities. It has been shown that the prevention of disability in children and the support of families raising handicapped children and children with disabilities are among the main priorities of the state social policy of the Russian Federation. The data on modern technologies for reducing the genetic burden in the population from the perspective of prevention of hereditary and congenital diseases, including orphan ones, has been presented. The results of studies indicating the increasing role of the intestinal microbiota in the development and prevention of a number of diseases affecting the formation of disability in children have been presented. The problem of combating antibiotic resistance is considered from a preventive perspective. A number of scientific studies is devoted to non-infectious pathology, which is becoming increasingly important in the formation of disability in children of different age groups, starting from the neonatal period. The actual data on the role of obesity in the formation of serious health disorders has been given. The opinion is expressed on the need to create a system of hygienic and medico-psychological safety of children's life in conditions of hyperinformatisation and the modern environmental situation. It is assumed that the implementation of the results of the proposed research into health care practice will make it possible to influence the processes of disability in a child on a deeper pathogenetic level as well as to improve the arrangement of preventive activities in this direction.

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“…However, the pharmaceutical industry is reluctant to develop new antibacterial drugs. [4,5]. Therefore all existing antibiotics were divided into 3 groups: access, observation, and reserve [5].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic Sensitivity of Clinical Isolates at Outpatient Unitin Tver, Russia: A Comparatives

Horak¹,

Gorodnichev²,

Морозов³

et al. 2020

AREM

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Background Discovery of antibiotics opened a new era in the treatment of bacterial diseases. However, the microorganisms are able to adapt and resist the effects of the drugs. Objective Our study is aimed to investigate the sensitivity of clinical specimens to antibiotics. Methods Clinical samples of 280 case record forms were collected at departments of surgery, urology and otorhinolaryngology in an ambulatory clinic (Tver, Russia) during 2019. The results of microbiologically assessed isolates from pharynx, nose, ears, eyes, wounds, sputum and urine underwent statistical analysis. Results The outcomes confirmed a general trend of reduced susceptibility of bacteria to antibiotics. The worst result was shown by protected Amoxicillin; practically no microorganisms were sensitive to it. Protected Cephalosporins Cephalosporins of IV generation and Imipenem were among the best, although not highly sensitive to all the pathogens. Conclusion United efforts of all states are required to combat the growing antibiotic resistance. It is necessary to adhere to strict regulations on dispense of antibiotics in pharmacies and the use of antibiotics therapy

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Antibiotic Resistance in Modern World

Cited by 32 publications

References 16 publications

Detection of meningococcus, pneumococcus, Haemophilus influenzae, and group A streptococcus DNA in pediatric adenoid bioptats

Detection of meningococcus, pneumococcus, Haemophilus influenzae, and group A streptococcus DNA in pediatric adenoid bioptats

On the Prospects for Child Disability Prevention Research

Antibiotic Sensitivity of Clinical Isolates at Outpatient Unitin Tver, Russia: A Comparatives

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