IMS Instrumentation I: Isolated data acquisition for ion mobility spectrometers with grounded ion sources

Lippmann, Martin; Kirk, Ansgar T.; Hitzemann, Moritz; Zimmermann, Stefan

doi:10.1007/s12127-020-00260-5

Cited by 16 publications

(18 citation statements)

References 20 publications

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“…To develop an approach to couple ChEC with our previously designed ESI drift tube IMS system, ,− we first had to construct a functional microfluidic device. Here, we were able to build on previous work, where we combined ChEC with mass spectrometry. − …”

Section: Resultsmentioning

confidence: 99%

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On-Line Coupling of Chip-Electrochromatography and Ion Mobility Spectrometry

et al. 2020

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We report the first hyphenation of chip-electrochromatography (ChEC) with ion mobility spectrometry (IMS). This approach combines the separation power of two electrokinetically driven separation techniques, the first in liquid phase and the second in gas phase, with a label-free detection of the analytes. For achieving this, a microfluidic glass chip incorporating a monolithic separation column, a nanofluidic liquid junction for providing post-column electrical contact, and a monolithically integrated electrospray emitter was developed. This device was successfully coupled to a custom-built high-resolution drift tube IMS with shifted potentials. After proof-of-concept studies in which a mixture of five model compounds was analyzed in less than 80 s, this first ChEC−IMS system was applied to a more complex sample, the analysis of herbicides spiked in the wine matrix. The use of ChEC before IMS detection not only facilitated the peak allocation and increased the peak capacity but also enabled analyte quantification. As both, ChEC and IMS work at ambient conditions and are driven by high voltages, no bulky pumping systems are needed, neither for the hydrodynamic pumping of the mobile phase as in high-performance liquid chromatography nor for generating a vacuum system as in mass spectrometry. Accordingly, the approach has great potential as a portable analytical system for field analysis of complex mixtures.

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Section: Resultsmentioning

confidence: 99%

“…For IMS detection, a custom-built drift tube IMS with shifted potentials was installed. ,− The high-resolution IMS is operated at ambient temperature and pressure with purified nitrogen as drift gas. The ions were introduced from the integrated chip emitter into the IMS inlet, equipped with a lens containing a 6 mm hole.…”

Section: Methodsmentioning

confidence: 99%

On-Line Coupling of Chip-Electrochromatography and Ion Mobility Spectrometry

et al. 2020

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“…For current amplification our in-house built amplifiers 28 with a gain of 5 GΩ and a bandwidth of 25 kHz were used. As both detectors are referenced to high electric potential the signals were digitized with an in-house developed isolated data acquisition 29 equipped with a 16 bit analog to digital converter. For all our experiments, purified air with a dew point of −90 °C was used as drift gas and sample carrier gas.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Compact and Sensitive Dual Drift Tube Ion Mobility Spectrometer with a New Dual Field Switching Ion Shutter for Simultaneous Detection of Both Ion Polarities

et al. 2020

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Ion mobility spectrometers (IMS) with field switching ion shutters are an excellent choice for trace gas detection, being extremely sensitive while having fast response times. However, as different target molecules may form positive, negative, or even ions of both polarities, it is beneficial to simultaneously detect both ion polarities. Here, we present a dual drift tube IMS with a new dual field switching ion shutter for gating both ion polarities and an X-ray ionization source in orthogonal configuration. The dual field switching ion shutter allows significantly improved ion gating and ion accumulation due to improved shielding of the ionization region from the drift field. Equipped with two 75 mm long high-performance drift tubes, the dual IMS reaches high resolving power of R = 90 with detection limits in the lower pptv range for different ketones, chlorinated hydrocarbons and methyl salicylate that forms ions in both polarities.

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“…Encouraged by our experience with the coupling of droplet microfluidics with mass spectrometric detection, ,,, as well as the recently realized coupling of chip chromatography with IMS, , we aimed in this work to explore the potential of IMS for droplet analysis. Therefore, a custom-built drift tube IMS with shifted potentials was employed as a detector, which was modified with two SST inlets. Before IMS analysis, the droplets were generated in capillaries using an SST tee-piece (VICI), adapting a T-junction approach used in microfluidic chips.…”

Section: Resultsmentioning

confidence: 99%

“…For IMS analysis, a custom-built drift tube IMS with shifted potentials was employed to provide ground potential at the inlet, as it was previously described in detail. ,− The instrument was operated at ambient conditions with purified nitrogen as drift gas (300 mL/min). The IMS inlet was adjusted with two stainless steel (SST) inlets with a 6 and 5 mm diameter hole, maintaining an electric field of 650 V/cm.…”

Section: Experimental Sectionmentioning

confidence: 99%

Coupling Droplet Microfluidics with Ion Mobility Spectrometry for Monitoring Chemical Conversions at Nanoliter Scale

et al. 2021

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We introduce the coupling of droplet microfluidics and ion mobility spectrometry (IMS) to address the challenges of label-free and chemical-specific detection of compounds in individual droplets. In analogy to the established use of mass spectrometry, droplet−IMS coupling can be also achieved via electrospray ionization but with significantly less instrumental effort. Because IMS instruments do not require high-vacuum systems, they are very compact, cost-effective, and robust, making them an ideal candidate as a chemical-specific end-of-line detector for segmented flow experiments. Herein, we demonstrate the successful coupling of droplet microfluidics with a custom-built high-resolution drift tube IMS system for monitoring chemical reactions in nL-sized droplets in an oil phase. The analytes contained in each droplet were assigned according to their characteristic ion mobility with limit of detections down to 200 nM to 1 μM and droplet frequencies ranging from 0.1 to 0.5 Hz. Using a custom sheath flow electrospray interface, we have further achieved the chemical-specific monitoring of a biochemical transformation catalyzed by a few hundred yeast cells, at single droplet level.

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IMS Instrumentation I: Isolated data acquisition for ion mobility spectrometers with grounded ion sources

Cited by 16 publications

References 20 publications

On-Line Coupling of Chip-Electrochromatography and Ion Mobility Spectrometry

On-Line Coupling of Chip-Electrochromatography and Ion Mobility Spectrometry

Compact and Sensitive Dual Drift Tube Ion Mobility Spectrometer with a New Dual Field Switching Ion Shutter for Simultaneous Detection of Both Ion Polarities

Coupling Droplet Microfluidics with Ion Mobility Spectrometry for Monitoring Chemical Conversions at Nanoliter Scale

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