Impulsivity in bipolar and substance use disorders

Ozten, Mustafa; Erol, Atila; Karayilan, Semra; Kapudan, Hilal; Orsel, Ertac Sertac; Kumsar, Neslihan Akkişi

doi:10.1016/j.comppsych.2015.02.013

Cited by 19 publications

(7 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meanwhile, the AM-1248 and CB-13 groups displayed significantly higher numbers of inactive lever presses than the vehicle group. These results may reflect that the administration of these SCBs triggered impulsive behavior, which has been commonly observed in SCB users (Ozten et al, 2015;Altıntaş et al, 2019). Additionally, these impulsive effects of SCBs are supported by previous studies that cannabinoid receptors are responsible for impulsive behavior (Leffa et al, 2019;Wiskerke et al, 2012).…”

Section: Discussionsupporting

confidence: 75%

Abuse Potential of Synthetic Cannabinoids: AM-1248, CB-13, and PB-22

Jang

Lee

et al. 2021

Biomol Ther (Seoul)

View full text Add to dashboard Cite

Currently, the expanding recreational use of synthetic cannabinoids (SCBs) threatens public health. SCBs produce psychoactive effects similar to those of tetrahydrocannabinol, the main component of cannabis, and additionally induce unexpected pharmacological side effects. SCBs are falsely advertised as legal and safe, but in reality, SCB abuse has been reported to cause acute intoxication and addictive disorders. However, because of the lack of scientific evidence to elucidate their dangerous pharmacological effects, SCBs are weakly regulated and continue to circulate in illegal drug markets. In the present study, the intravenous self-administration (IVSA) paradigm was used to evaluate the abuse potential of three SCBs (AM-1248, CB-13, and PB-22) in rats. All three SCBs maintained IVSA with a large number of infusions and active lever presses, demonstrating their reinforcing effects. The increase of active lever presses was particularly significant during the early IVSA sessions, indicating the reinforcementenhancing effects of the SCBs (AM-1248 and CB-13). The number of inactive lever presses was significantly higher in the SCB groups (AM-1248 and CB-13) than that in the vehicle group, indicating their impulsive effects. In summary, these results demonstrated that SCBs have distinct pharmacological properties and abuse potential.

show abstract

Section: Discussionsupporting

confidence: 75%

Abuse Potential of Synthetic Cannabinoids: AM-1248, CB-13, and PB-22

Jang

Lee

et al. 2021

Biomol Ther (Seoul)

View full text Add to dashboard Cite

show abstract

“…A review by Najt et al (2007) suggested that impulsivity is not only state related but also a trait component of BD and that it is a core feature of this illness. Consistent with these suggestions, several behavioral studies have consistently demonstrated higher trait impulsivity in patients with BD (Henna et al 2013; Powers et al 2013; Ozten et al 2015), adolescents with BD (Nandagopal et al 2011) and unaffected siblings of patients with BD (Wessa et al 2015). These findings support the hypothesis that increased trait impulsivity is an endophenotype of BD.…”

Section: Introductionmentioning

confidence: 78%

Structural correlates of trait impulsivity in patients with bipolar disorder and healthy controls: a surface-based morphometry study

Kuan

et al. 2017

Psychol. Med.

View full text Add to dashboard Cite

show abstract

“…However, the mean scores obtained in our study are more for all the three groups when compared to different studies conducted individually, in which mean scores of impulsivity (assessed by BIS-11) in Schizophrenia, BPAD and ADS are 46.1± 12.4, 49.5± 10.2 and 59.7 ± 9.3 respectively [13,14] . One study comparing impulsivity in BPAD and ADS individuals have found that the difference in mean BIS-11 scores was not statistically significant in both the groups [15] . This disparity could be due to the phase of illness at which the patients were included into the study.…”

Section: Discussionmentioning

confidence: 96%