Structural correlates of trait impulsivity in patients with bipolar disorder and healthy controls: a surface-based morphometry study

Tu, Pei-Chi; Kuan, Yi-Hsuan; Li, Cheng Ta; Su, Tung‐Ping

doi:10.1017/s0033291716003299

Cited by 19 publications

(21 citation statements)

References 46 publications

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“…In addition, findings from recent structural neuroimaging studies (e.g., Cho et al, 2013;Tu, Kuan, Li, & Su, 2017) suggest that only the grey matter volume in LDLPFC but not RDLPFC correlates with self-report measures of impulsivity. The third possible explanation is that the rTMS modulation effect on DLPFC may be only reflected by the tasks measuring proactive rather than reactive motor inhibition (Brevet-Aeby et al, 2016).…”

Section: Discussionmentioning

confidence: 97%

The Effects of rTMS on Impulsivity in Normal Adults: a Systematic Review and Meta-Analysis

2018

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Impulsivity is a multi-dimensional construct that is regarded as a symptom of many psychiatric disorders. Harm resulting from impulsive behaviour can be substantial for the individuals concerned, for their social network, and for wider society. Therefore, the importance of developing therapeutic interventions to target impulsivity is paramount. We conducted a systematic review and meta-analysis of the literature from AMED, Embase, Medline, and PsycINFO databases on the use of repetitive transcranial magnetic stimulation (rTMS) in healthy adults to modulate different subdomains (motor, temporal and reflection) of impulsivity. The results indicated that rTMS has distinct effects on different impulsivity subdomains. It has a significant, albeit small, effect on modulating motor impulsivity (g = 0.30, 95% CI, 0.17 to 0.43, p < .001) and a moderate effect on temporal impulsivity (g = 0.59, 95% CI, 0.32 to 0.86, p < .001). Subgroup analyses (e.g., excitatory vs. inhibitory rTMS, conventional rTMS vs. theta burst stimulation, analyses by stimulation sites, and type of outcome measure used) identified key parameters associated with the effects of rTMS on motor and temporal impulsivity. Age, sex, stimulation intensity and the number of pulses were not significant moderators for effects of rTMS on motor impulsivity. Due to lack of sufficient data to inform a meta-analysis, it has not been possible to assess the effects of rTMS on reflection impulsivity. The present findings provide preliminary evidence that rTMS can be used to modulate motor and temporal impulsivity in healthy individuals. Further studies are required to extend the use of rTMS to modulate impulsivity in those at most risk of engaging in harmful behaviour as a result of impulsivity, such as patients with offending histories and those with a history of self-harming behaviour.

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Section: Discussionmentioning

confidence: 97%

The Effects of rTMS on Impulsivity in Normal Adults: a Systematic Review and Meta-Analysis

2018

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“…Studies on the neurobiological correlates of impulsive traits have the potential to uncover other underlying processes that may contribute to impulsive and risky phenotypes. Extant neuroimaging research has demonstrated associations between brain structure and impulsivity in adults [16][17][18]. For example, studies have shown positive correlations between self-reported impulsivity and volume of the anterior cingulate gyrus and dorsolateral prefrontal cortex [19].…”

Section: Neuroanatomical Correlates Of Impulsivitymentioning

confidence: 99%

Cortical Thickness Links Impulsive Personality Traits and Risky Behavior

et al. 2019

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Impulsive personality traits are often predictive of risky behavior, but not much is known about the neurobiological basis of this relationship. We investigated whether thickness of the cortical mantle varied as a function of impulsive traits and whether such variation also explained recent risky behavior. A community sample of 107 adults (ages 18-55; 54.2% men) completed self-report measures of impulsive traits and risky behavior followed by a neuroimaging protocol. Using the three-factor model of impulsive traits derived from the UPPS-P Impulsive Behavior Scale, analysis of the entire cortical mantle identified three thickness clusters that related to impulsive traits. Sensation seeking was negatively related to thickness in the right pericalcarine cortex, whereas impulsive urgency was positively associated with thickness in the left superior parietal and right paracentral lobule. Notably, follow-up analyses showed that thickness in the right pericalcarine cortex also related to recent risky behavior, with the identified cluster mediating the association between sensation seeking and risky behavior. Findings suggest that reduced thickness in the pericalcarine region partially explains the link between sensation seeking and the tendency to engage in risky behavior, providing new insight into the neurobiological basis of these relationships.

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“…Dalley and Robbins 2017), attention-deficit hyperactivity disorder (Ahmad andHinshaw 2017, Martel et al 2017), antisocial personality disorder (González et al 2016, Martel et al 2017, and bipolar disorder (Tu et al 2017), this finding supports the notion that the beneficial effects of nature may be especially evident in those individuals who possess greater vulnerability to mental-health issues. The implications of these results are twofold.…”

Section: Associations Between Momentary Mental Well-being Score In mentioning

confidence: 75%

“…One of the aims of our project was to explore how the impact of the surrounding built environment on the mental well-being of an individual might depend on their vulnerability to developing mental-health issues. For this reason, we included an assessment of trait impulsivity, a well-established psychological measure of one's tendency to behave with little forethought, reflection, or consideration of the consequences (Mayhew and Powell 2014 (Ahmad andHinshaw 2017, Martel et al 2017), antisocial personality disorder (González et al 2016, Martel et al 2017, and bipolar disorder (Tu et al 2017). We used the data to test three related hypotheses: (1) exposure to natural features, including trees, the sky, birdsong, and water, would be associated with higher levels of momentary mental wellbeing; (2) these effects would still be evident in subsequent assessments, in which people are no longer exposed to trees, the sky, birdsong, and water, indicating time-lasting benefits;…”

Section: The Urban Mind Toolmentioning

confidence: 99%

Urban Mind: Using Smartphone Technologies to Investigate the Impact of Nature on Mental Wellbeing in Real Time

Bakolis¹,

Hammoud²,

Smythe³

et al. 2018

ISEE Conference Abstracts

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Existing evidence on the beneficial effects of nature on mental health comes from studies using cross-sectional designs. We developed a smartphone-based tool (Urban Mind; www.urbanmind.info) to examine how exposure to natural features within the built environment affects mental well-being in real time. The tool was used to monitor 108 individuals who completed 3013 assessments over a 1-week period. Significant immediate and lagged associations with mental well-being were found for several natural features. These associations were stronger in people with higher trait impulsivity, a psychological measure of one's tendency to behave with little forethought or consideration of the consequences, which is indicative of a higher risk of developing mental-health issues. Our investigation suggests that the benefits of nature on mental well-being are time-lasting and interact with an individual's vulnerability to mental illness. These findings have potential implications from the perspectives of global mental health as well as urban planning and design.

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Structural correlates of trait impulsivity in patients with bipolar disorder and healthy controls: a surface-based morphometry study

Cited by 19 publications

References 46 publications

The Effects of rTMS on Impulsivity in Normal Adults: a Systematic Review and Meta-Analysis

The Effects of rTMS on Impulsivity in Normal Adults: a Systematic Review and Meta-Analysis

Cortical Thickness Links Impulsive Personality Traits and Risky Behavior

Urban Mind: Using Smartphone Technologies to Investigate the Impact of Nature on Mental Wellbeing in Real Time

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