Impulsivity (delay discounting) as a predictor of acquisition of IV cocaine self-administration in female rats

Perry, Jennifer L.; Larson, Erin B.; German, Jonathan P.; Madden, Gregory J.; Carroll, Marilyn E.

doi:10.1007/s00213-004-1994-4

Cited by 342 publications

(377 citation statements)

References 54 publications

(69 reference statements)

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“…However, other reports have found that impulsive choice was not altered by amphetamine [15,27] or cocaine [46]. Several procedural factors may account for these discrepant findings, including the type of reinforcer offered (i.e., water or food), whether a cue was present during the delay to the larger reinforcer, and differences in baseline level of impulsivity [61].…”

Section: Introductionmentioning

confidence: 82%

“…In rodents, impulsive choice predicts acquisition of cocaine self-administration [62,65] and cocaine-primed reinstatement of cocaine-seeking behavior [65]. Impulsive choice also predicts greater alcohol consumption in a two-bottle choice test [70], more self-administered nicotine infusions under a progressive ratio schedule [23], and greater resistance to extinction of nicotine-seeking behavior and cue-induced reinstatement of nicotine-seeking [23].…”

Section: Introductionmentioning

confidence: 99%

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Impulsive choice and environmental enrichment: Effects of d-amphetamine and methylphenidate

Perry

Stairs

Bardo

2008

Behavioural Brain Research

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Individual differences in impulsive choice and rearing in differential environments are factors that predict vulnerability to drug abuse. The present study determined if rearing influences impulsive choice, and if d-amphetamine or methylphenidate alters impulsive choice in differentially-reared rats. Male Sprague-Dawley rats were raised from 21 days of age in either an enriched condition (EC) or an isolated condition (IC) and were tested as young adults on an adjusting delay task. In this task, two levers were available and a response on one lever yielded one 45 mg food pellet immediately, whereas a response on the other yielded three pellets after an adjusting delay. The delay was initially set at 6 sec, and it decreased or increased by 1 sec following responses on the immediate or delayed levers, respectively. A mean adjusted delay (MAD) was calculated upon completion of each daily session, and it served as the quantitative measure of impulsivity. Once MADs stabilized, rats were injected with saline, d-amphetamine (0.5, 1.0, or 2.0 mg/kg, s.c.), or methylphenidate (2.5, 5.0, or 10.0 mg/kg, s.c.) 15 min prior to adjusting delay sessions. EC rats had higher baseline MADs (were less impulsive) than IC rats. Additionally, administration of d-amphetamine, but not methylphenidate, dose-dependently increased impulsive choice (decreased MADs) in EC rats. In IC rats, d-amphetamine and methylphenidate dose-dependently decreased impulsivity (increased MADs). These results indicate that rearing environment influences impulsive choice and moderates the effect of psychostimulants on impulsive choice. Specifically, psychostimulants may decrease environment-dependent impulsive choice in individuals with high levels of impulsivity (e.g., those with ADHD), whereas they may increase impulsive choice in individuals with low levels of impulsivity.

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Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Impulsive choice and environmental enrichment: Effects of d-amphetamine and methylphenidate

Perry

Stairs

Bardo

2008

Behavioural Brain Research

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123

113

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“…Impulsivity is related to drug addiction by studies reporting that rats that are intolerant of reward delay subsequently acquire cocaine self-administration more rapidly and at lower doses (Perry et al, 2005) and also self-administer more alcohol (Poulos et al, 1995(Poulos et al, , 1998 than do delaytolerant rats (for review, see Olmstead, 2006). In addition, Lewis rats, as compared to Fischer rats, exhibit more intolerance to reward delay (Anderson and Woolverton, 2005) and more readily self-administer drugs of abuse, including cocaine (Kosten et al, 1997;Haile and Kosten, 2001), morphine (Ambrosio et al, 1995;Martin et al, 1999), and alcohol (Suzuki et al, 1988).…”

Section: Vulnerability To Impulsivitymentioning

confidence: 99%

Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse

Tomie

Grimes

Pohorecky

2008

Brain Research Reviews

147

132

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Drug abuse researchers have noted striking similarities between behaviors elicited by Pavlovian signtracking procedures and prominent symptoms of drug abuse. In Pavlovian sign-tracking procedures, repeated paired presentations of a small object (conditioned stimulus, CS) with a reward (unconditioned stimulus, US) elicits a conditioned response (CR) that typically consists of approaching the CS, contacting the CS, and expressing consummatory responses at the CS. Signtracking CR performance is poorly controlled and exhibits spontaneous recovery and long-term retention, effects that resemble relapse. Sign-tracking resembles psychomotor activation, a syndrome of behavioral responses evoked by addictive drugs, and the effects of sign-tracking on corticosterone levels and activation of dopamine pathways resemble the neurobiological effects of abused drugs. Finally, the neurobiological profile of individuals susceptible to sign-tracking resembles the pathophysiological profile of vulnerability to drug abuse, and vulnerability to sign-tracking predicts vulnerability to impulsive responding and alcohol self-administration. Implications of sign-tracking for models of drug addiction are considered.

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“…Examples of drug-seeking-prone behaviors are voluntary or forced reactivity to a novel environment (Piazza et al, 1989(Piazza et al, , 1990(Piazza et al, , 2000Bardo et al, 1996;Klebaur and Bardo, 1999;Klebaur et al, 2001;Mantsch et al, 2001;Cain et al, 2004), novelty choice (Cain et al, 2005), wheel-running (Larson and Carroll 2005a), higher intake of saccharin-and sucrose-adulterated foods or liquids (Gahtan et al, 1996;Gosnell, 2000;Gosnell and Krahn, 1992;Gosnell et al, 1995) and dietary fat (Marks-Kaufman and Lipeles, 1982;Krahn and Gosnell, 1991), impulsiveness for food reward (Perry et al 2005(Perry et al , 2007c, and stress reactivity (Piazza and LeMoal, 1996;Homberg et al, 2002). This approach to identifying drug abuse vulnerability factors can also be accomplished by selective breeding for the phenotype of interest, and similar results have emerged in the case of saccharin intake and drug self-administration (Dess et al, 1998;Carroll et al, 2002Perry et al, 2007a,b).…”

Section: Introductionmentioning

confidence: 99%

Higher locomotor response to cocaine in female (vs. male) rats selectively bred for high (HiS) and low (LoS) saccharin intake

Carroll

Anderson

Morgan

2007

Pharmacology Biochemistry and Behavior

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Rats selectively bred for high saccharin consumption (HiS) self-administer more oral ethanol and i.v. cocaine than those selectively bred for low saccharin consumption (LoS). Male and female drug-seeking-prone (HiS) and -resistant (LoS) rats were used in the present experiment to test the prediction that cocaine-induced locomotor activity and sensitization varied with sex and their selective breeding status (HiS and LoS). All rats were intermittently exposed over 2 weeks to pairs of sequential saline and cocaine injections, separated by 45 min. The first 5 pairs of injections, each separated by 2-3 days (10-12 days total), were given to examine the development of cocaineinduced locomotor activity and the development of locomotor sensitization, which was determined by comparing the effects of cocaine injection 1 with injection 6, which was given 2 weeks after the 5 pairs of intermittent injections. Results indicated that after the first injection pair (saline, cocaine) the HiS and LoS groups did not differ (saline vs. cocaine) in locomotor activity; however, after cocaine injections 1, 5 and 6, HiS females were more active than HiS males and LoS females. There were also significant phenotype differences (HiS > LoS) in locomotor activity after cocaine injections 5 and 6. There was only a weak sensitization effect in cocaine-induced locomotor activity in HiS females after cocaine injection 5 (compared to 1); however it was not present after injection 6 or in other groups. The lack of a strong sensitization effect under these temporal and dose conditions was inconsistent with previous reports. However, the results showing HiS > LoS and females > males on cocaine-induced activity measures are consistent with several measures of cocaine-seeking behavior (acquisition, maintenance, escalation, extinction, and reinstatement), and they suggest that cocaine-induced locomotor activity and sensitization are behavioral markers of drug-seeking phenotypes.

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Impulsivity (delay discounting) as a predictor of acquisition of IV cocaine self-administration in female rats

Abstract: Performance on the delay discounting model of impulsivity predicted vulnerability to subsequent acquisition of cocaine self-administration.

Cited by 342 publications

References 54 publications

Impulsive choice and environmental enrichment: Effects of d-amphetamine and methylphenidate

Impulsive choice and environmental enrichment: Effects of d-amphetamine and methylphenidate

Behavioral characteristics and neurobiological substrates shared by Pavlovian sign-tracking and drug abuse

Higher locomotor response to cocaine in female (vs. male) rats selectively bred for high (HiS) and low (LoS) saccharin intake

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