Impulsive and aggressive traits and increased peripheral inflammatory status as psychobiological substrates of homicide behavior in schizophrenia

Balcıoğlu, Yasin Hasan; Balcioglu, Simge Seren Kirlioglu; Öncü, Fatih; Türkcan, Ahmet; Yorulmaz, Abdullah Coskun

doi:10.1016/j.ejpsy.2022.01.004

Cited by 12 publications

(11 citation statements)

References 47 publications

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“…Sourav et al [ 40 ] showed that interferon-gamma (IFN-G) and interleukin 10 (IL10) were strongly associated with aggressive behavior in schizophrenia. According to a recent study, CAR may predict a distinct tendency to fatal aggression in schizophrenia as a proxy marker of peripheral inflammation (Yasin Hasan [ 41 ]). However, the biomarkers mentioned in the above study are not routine clinical tests and cannot be tested in most basic hospitals.…”

Section: Discussionmentioning

confidence: 99%

The Neutrophil-Lymphocyte Ratio Is Positively Correlated with Aggression in Schizophrenia

Tong

Zhu

Wang

et al. 2022

BioMed Research International

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To find biomarkers to assess the risk of aggression, we looked at the association between aggression and levels of body inflammation in patients with schizophrenia. The Modified Overt Aggression Scale (MOAS) score was used to divide the aggressive ( n = 72 ) and nonaggressive ( n = 141 ) groups. The Brief Psychiatric Rating Scale (BPRS) is a tool for determining the severity of a patient’s condition. After measuring the number of inflammatory cells in the peripheral blood, the platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and monocyte-lymphocyte ratio (MLR) were estimated. We investigated the relationship between aggressive behavior, bodily inflammation, and BPRS. Before therapy, the aggressive group’s BPRS score, white blood cell (WBC) count, neutrophil count, monocyte count, NLR, and MLR were considerably more significant than the nonaggressive group’s. After therapy, statistically significant variations in total BPRS score and neutrophil count between the two groups. According to correlation analysis before and after treatment, aggressive behavior was positively connected with neutrophil count, NLR, and BPRS score. The presence of aggressive behavior in schizophrenic patients indicates the severity of the disorder to some degree. NLR can be used as an objective biomarker to quickly assess the risk of aggression in schizophrenic patients.

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Section: Discussionmentioning

confidence: 99%

The Neutrophil-Lymphocyte Ratio Is Positively Correlated with Aggression in Schizophrenia

Tong

Zhu

Wang

et al. 2022

BioMed Research International

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“…The link between crime, violence, homicidal behavior and inflammation in mental disorders has only recently begun to be studied [ 8 , 12 , 13 , 14 , 15 , 23 ]. However, no research has been conducted to investigate the relationship between peripheral inflammation markers and impulsivity and aggression in schizophrenia patients with and without criminal involvement.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly to this study, we found that MPV values were low and PDW values were high in schizophrenia patients involved in crime. Because the number of studies conducted with criminally involved patients in the literature is quite limited [ 14 , 15 ], it is not possible to generalize the results obtained. However, it is expected that these data, which are compatible with one another, will contribute to the literature.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that there is a significant relationship between inflammatory factors and committal in diseases such as antisocial personality disorder and bipolar affective disorder, where aggression and impulsivity are prominent [ 13 , 14 ]. Another study compared schizophrenia patients who committed murder in the first degree to those who committed other crimes, and it was found that some peripheral inflammatory factors were higher in those who committed intentional homicide [ 15 ]. However, no study was found in the literature that examined the relationship between peripheral inflammatory markers, aggression, impulsivity, and criminal behavior in schizophrenia patients.…”

Section: Introductionmentioning

confidence: 99%

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Examination of the Relationship between Peripheral Inflammation Markers and Impulsivity and Aggression in Schizophrenia Patients Involved and Not Involved in Crime

Kaya

TAŞCI

KILIÇ>

et al. 2023

JPM

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Aim: The aim of this study was to examine the relationship between peripheral inflammatory markers and aggression and impulsivity in schizophrenia patients with and without criminal histories. Materials and Methods: The study was conducted with patients with schizophrenia involved in crimes and hospitalized in the Forensic Psychiatry ward of Elazığ Fethi Sekin City Hospital and patients with schizophrenia not involved in crimes and hospitalized in the psychiatry ward of Elazığ Mental Health and Diseases Hospital. All participants completed the Buss–Waren Aggression Scale (BWAS), the Barratt Impulsiveness Scale-11 (BIS-11), and the Positive and Negative Symptom Scale (PANSS). Before treatment, venous blood samples were taken for laboratory measurements on the first day of hospitalization. Results: All participants were male. The mean age of those involved in a crime was 39 ± 9.7 years, while the mean age of those not involved in a crime was 41.2 ± 10.7 years. The PANSS all subscale and total scores of the patients with schizophrenia who were involved in a crime were significantly higher than the group who were not involved (p values were p < 0.001, p = 0.001, p = 0.043, p = 0.001, respectively). The BWAS—physical aggression (p = 0.007) and total scores of the scale (p = 0.046) and BIS-11—inability to plan (p = 0.002) scores of the group involved in a crime were higher than the group not involved. As for laboratory parameters, MCH, MCHC, PDW, eosinophils, basophils, RDW-CV, and RDW-SD values were significantly higher in those involved in crime, while MPV, creatinine, albumin, and LDH values were lower. CRP and CRP/albumin values were significantly higher, while neutrophil/albumin values were significantly lower in those who committed murder in the first degree than those who committed other crimes. Conclusion: Based on our results, we found that inflammatory agents were significantly increased in forensic schizophrenia patients with high aggression scores. Significant correlations between some inflammatory factors and impulsivity and aggression scores and differences in these factors according to crime types showed that these factors might be related to violence and criminal behavior. There is a need for further large-scale studies on this subject at different stages of the disease.

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“…Sourav et al [40] showed that interferon-gamma (IFN-G) and interleukin 10 (IL10) were strongly associated with aggressive behavior in schizophrenia. According to a recent study, CAR may predict a distinct tendency to fatal aggres-sion in schizophrenia as a proxy marker of peripheral inflammation (Yasin Hasan [41]). However, the biomarkers mentioned in the above study are not routine clinical tests and cannot be tested in most basic hospitals.…”

Section: Discussionmentioning

confidence: 99%

The neutrophil-lymphocyte ratio is positively correlated with aggression in schizophrenia

Zhu

Wang

et al. 2022

Preprint

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To find biomarkers to assess the risk of aggression, we looked at the association between aggression and levels of body inflammation in patients with schizophrenia. The Modified Overt Aggression Scale (MOAS) score was used to divide the aggressive (n=72) and nonaggressive (n=141) groups. The Brief Psychiatric Rating Scale (BPRS) is a tool for determining the severity of a patient's condition. After measuring the number of inflammatory cells in the peripheral blood, the platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and monocyte-lymphocyte ratio (MLR) were estimated. We investigated the relationship between aggressive behavior, bodily inflammation, and BPRS. Before therapy, the aggressive group's BPRS score, white blood cell (WBC) count, Neutrophils count, Monocyte count, NLR, and MLR were considerably more significant than the nonaggressive group's. After therapy, statistically significant variations in total BPRS score and neutrophils count between the two groups. According to correlation analysis before and after treatment, aggressive behavior was positively connected with neutrophils count, NLR, and BPRS score. The presence of aggressive behavior in schizophrenic patients indicates the severity of the disorder to some degree. NLR can be used as an objective biomarker to quickly assess the risk of aggression in schizophrenic patients.

show abstract

Impulsive and aggressive traits and increased peripheral inflammatory status as psychobiological substrates of homicide behavior in schizophrenia

Cited by 12 publications

References 47 publications

The Neutrophil-Lymphocyte Ratio Is Positively Correlated with Aggression in Schizophrenia

The Neutrophil-Lymphocyte Ratio Is Positively Correlated with Aggression in Schizophrenia

Examination of the Relationship between Peripheral Inflammation Markers and Impulsivity and Aggression in Schizophrenia Patients Involved and Not Involved in Crime

The neutrophil-lymphocyte ratio is positively correlated with aggression in schizophrenia

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