Improving vitamin D3 stability to environmental and processing stresses using mixed micelles

Mulrooney, Steven L.; O’Neill, Graham J.; Brougham, Dermot F.; Lyng, James G.; O’Riordan, Dolores

doi:10.1016/j.foodchem.2021.130114

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…However, in this study it appears that the increased permeability of micellar Vitamin D 3 does not correlate with increased solubility or reduced particle size-since LipoMicel has similar solubility characteristics (Figure 2) and particle size distribution (Figure 5 and Table 4) as the baseline control. While other reports on Vitamin D micelles focused on structural morphology, stability, bioaccessibility and controlled release without reporting permeability [29,49,50], this study demonstrates that biological experiments provide better insights on Vitamin D absorption than simple diffusion modelled by physical and chemical characterization of the formulations [12]. In fact, the results of our study suggest that the absorption process involves biological mechanisms such as cholesterol transporters and cellmembrane efflux pumps such as ABCB1, which would support previous findings [32,51].…”

Section: Discussionsupporting

confidence: 85%

Designing Vitamin D3 Formulations: An In Vitro Investigation Using a Novel Micellar Delivery System

Chang

Zhang

et al. 2023

Nutraceuticals

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Vitamin D is an essential nutrient with important immunomodulatory properties. As a fat-soluble compound, Vitamin D (and its D3 form) is immiscible with water, which presents challenges to absorption. In an in vitro setting, the current study characterizes novel micellar formulations of Vitamin D3 designed to improve absorption. Techniques used to evaluate and compare the micellar formulations against a non-micellar formula include the following: cryo-SEM to determine morphology; laser diffraction to determine particle size and distribution; zeta potential to determine stability of the particles; solubility assays to determine solubility in water and gastrointestinal media; and Caco-2 cell monolayers to determine intestinal permeability. Results show advantageous features (particle size range in the low micrometres with an average zeta potential of −51.56 ± 2.76 mV), as well as significant improvements in intestinal permeability, in one optimized micellar formula (LipoMicel®). When introduced to Caco-2 cells, LipoMicel’s permeability was significantly better than the control (p < 0.01; ANOVA). Findings of this study suggest that the novel micellar form of Vitamin D3 (LipoMicel) has the potential to promote absorption of Vitamin D3. Thus, it can serve as a promising candidate for follow-up in vivo studies in humans.

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Section: Discussionsupporting

confidence: 85%

Designing Vitamin D3 Formulations: An In Vitro Investigation Using a Novel Micellar Delivery System

Chang

Zhang

et al. 2023

Nutraceuticals

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“…The stability of HAS in HAS-NLCs was evaluated over time on the basis of the retention rate of HAS, compared with free-HAS, under flowing oxygen, different light conditions and different temperatures (Sheng et al., 2018 ; Mulrooney et al., 2021 ). Briefly, HAS-NLCs and free-HAS were transferred into beakers (10 mL), and then kept in a dark place with flowing oxygen at room temperature.…”

Section: Methodsmentioning

confidence: 99%

Design of hydroxy-α-sanshool loaded nanostructured lipid carriers as a potential local anesthetic

Tan

Liu

et al. 2022

Drug Delivery

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Hydroxy-α-sanshool (HAS), extracted from Zanthoxylum piperitum , is commonly used in oral surgery to relief pain. However, the application of HAS is limited in clinical practice due to its poor stability. This study focuses on the design of a novel nano-formulation delivery system for HAS to improve its stability and local anesthetic effect. Hydroxy-α-sanshool loaded nanostructured lipid carriers (HAS-NLCs) were prepared by melting emulsification and ultra-sonication using monostearate (GMS) and oleic acid (OA) as lipid carriers, and poloxamer-188 (F68) as a stabilizer. Besides, the formulation was optimized by response surface methodology (RSM). Then, the best formulation was characterized for particle size, polydispersity index (PDI), zeta potential, entrapment efficiency (EE%), drug loading (DL%), differential scanning calorimetry (DSC), and morphology (transmission electron microscopy, TEM). The obtained HAS-NLCs were homogeneous, near spherical particles with high DL% capacity. The stability of HAS-NLCs against oxygen, light, and heat was greatly improved over 10.79 times, 3.25 times, and 2.09 times, respectively, compared to free HAS. In addition, HAS-NLCs could exhibit sustained release in 24 h following a double-phase kinetics model in vitro release study. Finally, HAS-NLCs had excellent anesthetic effect at low dose in formalin test compared with free HAS and lidocaine, which indicated HAS-NLCs were a potential local anesthesia formulation in practice.

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Vitamin D in food—Compounds, stability, sources

Jakobsen,

Jensen

2024

Feldman and Pike's Vitamin D

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Improving vitamin D3 stability to environmental and processing stresses using mixed micelles

Cited by 6 publications

References 35 publications

Designing Vitamin D3 Formulations: An In Vitro Investigation Using a Novel Micellar Delivery System

Designing Vitamin D3 Formulations: An In Vitro Investigation Using a Novel Micellar Delivery System

Design of hydroxy-α-sanshool loaded nanostructured lipid carriers as a potential local anesthetic

Vitamin D in food—Compounds, stability, sources

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