Improving the sensitivity of amino-silanized sensors using self-structured silane layers: Application to fluorescence pH measurement

Kateklum, Rutjaphan; Gauthier‐Manuel, Bernard; Pieralli, Christian; Mankhetkorn, Samlee; Wacogne, Bruno

doi:10.1016/j.snb.2017.04.049

Cited by 10 publications

(9 citation statements)

References 5 publications

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“…However, using silicon allows calculating the amine function density using Fourier Transform Infrared Spectroscopy. Details of the experimental processes for silanization, grafting and amine quantification can be found in [4]. Using only APTMS, we measured a concentration of 365 molecules/nm -2 .…”

Section: Comparing Both Silanization Methods Performing Ph Measuremenmentioning

confidence: 99%

Sensitivity enhancement of a fluorescent pH sensor by double silanization of the sensing surface

Gauthier‐Manuel

Kateklum

Pieralli

et al. 2019

Materials Today: Proceedings

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The goal of this work concerns a new method to substantially increase the sensitivity of a fluorescence pH sensor. The method is based on a double silanization method. Two methods are compared: one using APTMS (3-Aminopropyl)trimethoxysilane) only and another one using both APTMS and APDMS (3-Aminopropyl)dimethoxymethylsilane). Using the second method, sensor's sensitivity is improved by more than 500 %.

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Section: Comparing Both Silanization Methods Performing Ph Measuremenmentioning

confidence: 99%

Sensitivity enhancement of a fluorescent pH sensor by double silanization of the sensing surface

Gauthier‐Manuel

Kateklum

Pieralli

et al. 2019

Materials Today: Proceedings

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“…Glass supports or metal coated surfaces are generally employed to create a sensitive grafted organic layer of functionalized ligands with the advantage of the manipulability and processability of a macro-supported nanostructure. By using this approach, B. Wacogne and coworkers, developed a molecular porous nanolayer formed by amino-silanization on glass substrates using different functionalization strategies ( Figure 2 , box 4) [ 87 ]. A glass coated with (3-aminopropyl)trimethoxysilane (APTMS) and (3-aminopropyl)dimethoxymethylsilane (APDMS) was used as support for dye grafting ( Figure 2 , box 4), a chemical reaction used to covalent link a sensing molecule to the supported coat.…”

Section: Nano-sized Visual Ph Sensorsmentioning

confidence: 99%

“…MOF named BUT-62 is obtained from a fluorescent asymmetric ligand mixed to a zirconium oxo-complex (Zr cyan-polyhedron, O red spheres, N blue spheres; accession code 1446514) Box 4. pH VS from highly engineered nanomaterials. A “grafting” reaction causes binding of fluorescein molecule, as succinimidyl ester, to a glass (semi-transparent blue rectangle) coated with (3-aminopropyl)trimethoxysilane (APTMS, blue segment) [ 87 ]. Adapted from references indicated in square brackets.…”

Section: Figures Scheme and Tablementioning

confidence: 99%

Visual pH Sensors: From a Chemical Perspective to New Bioengineered Materials

Costanzo

Panunzi

2021

Molecules

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Many human activities and cellular functions depend upon precise pH values, and pH monitoring is considered a fundamental task. Colorimetric and fluorescence sensors for pH measurements are chemical and biochemical tools able to sense protons and produce a visible signal. These pH sensors are gaining widespread attention as non-destructive tools, visible to the human eye, that are capable of a real-time and in-situ response. Optical “visual” sensors are expanding researchers’ interests in many chemical contexts and are routinely used for biological, environmental, and medical applications. In this review we provide an overview of trending colorimetric, fluorescent, or dual-mode responsive visual pH sensors. These sensors include molecular synthetic organic sensors, metal organic frameworks (MOF), engineered sensing nanomaterials, and bioengineered sensors. We review different typological chemical entities of visual pH sensors, three-dimensional structures, and signaling mechanisms for pH sensing and applications; developed in the past five years. The progression of this review from simple organic molecules to biological macromolecules seeks to benefit beginners and scientists embarking on a project of pH sensing development, who needs background information and a quick update on advances in the field. Lessons learned from these tools will aid pH determination projects and provide new ways of thinking for cell bioimaging or other cutting-edge in vivo applications.

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“…In this case, [H + ] response from an area of interest is mapped using a dye whose fluorescence is inversely proportional to [H + ] (SNARF). [ 30 ] The algorithm leverages a neural network composed of an input layer, a hidden layer, and an output layer (Figure 3A). The input layer receives the error value between the desired and the measured [H + ] values, information on prior [H + ] stimuli, as well as current and previous [H + ] response to the applied V H+ .…”

Section: Figurementioning

confidence: 99%

Machine Learning‐Driven Bioelectronics for Closed‐Loop Control of Cells

Selberg

Jafari

Mathews

et al. 2020

Advanced Intelligent Systems

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Life is built upon closed-loop feedback and regulation systems that maintain a delicate balance of environmental and metabolic conditions that support cellular function. [1] Bioelectronic devices interface electronic devices with biology with potential for sensing and actuation. [2-5] A challenge for bioelectronic devices is translating between ionic and biochemical signals that dominate biology into electronic currents in the devices and vice versa. Iontronics addresses this challenge by modulating ions directly at the device level rather than electron and holes as in traditional semiconductors. [6] Electrophoretic ion pumps mediate the delivery of ions and charged molecules with an induced electric field [7] to treat epilepsy, [6] chronic pain, [8] inflammation, [9] and to actuate movement in plants. [10] In addition, bioprotonic devices can sense and actuate the flow of H þ in field effect transistors (H þ-FETs), [11,12] enzymatic logic gates, [12] and ion channels. [13] A cell's resting potential, V mem , is an electrical control signal that occurs between the interior of the cell and the extracellular environment regulated by ion channels. [14] In nonexcitable cells, [15] V mem affects cell physiology and functions such as proliferation, differentiation, migration, and apoptosis, as well as cell-cell communication and large-scale morphogenesis. [16] Recently, optically actuated

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Improving the sensitivity of amino-silanized sensors using self-structured silane layers: Application to fluorescence pH measurement

Cited by 10 publications

References 5 publications

Sensitivity enhancement of a fluorescent pH sensor by double silanization of the sensing surface

Sensitivity enhancement of a fluorescent pH sensor by double silanization of the sensing surface

Visual pH Sensors: From a Chemical Perspective to New Bioengineered Materials

Machine Learning‐Driven Bioelectronics for Closed‐Loop Control of Cells

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