Improving the Performance of a Cycloidal Coded-Aperture Miniature Mass Spectrometer

Vyas, Raul; Aloui, Tanouir; Horvath, Kathleen L.; Herr, Philip J.; Kirley, Matt; Keil, Adam D.; Carlson, James E.; Keogh, Justin; Sperline, Roger P.; Denton, M. Bonner; Sartorelli, M. L.; Stoner, Brian R.; Gehm, Michael E.; Glass, Jeffrey T.; Amsden, Jason J.

doi:10.1021/jasms.0c00378

Cited by 6 publications

(19 citation statements)

References 51 publications

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“…For example, the C-CAMMS-MP prototype described previously has a system response that depends on m/z due to a mass-dependent curvature of ions in the ion source resulting in nonuniform illumination of the coded aperture. 10 This paper presents two methods to eliminate most artifacts in the C-CAMMS-MP prototype. First, we applied an enhanced approach to estimate the system response by making the system response a function of m/z to compensate for the mass-dependent curvature of the ions in the ion source.…”

Section: Discussionmentioning

confidence: 99%

Spectral Reconstruction Improvement in a Cycloidal Coded-Aperture Mass Spectrometer

Aloui,

Vyas,

Francini

et al. 2024

J. Am. Soc. Mass Spectrom.

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Spatial aperture coding is a technique used to improve throughput without sacrificing resolution both in optical spectroscopy and sector mass spectrometry (MS). Previous work demonstrated that aperture coding combined with a position-sensitive array detector in a miniature cycloidal mass spectrometer was successful in providing high-throughput, high-resolution measurements. However, due to poor alignment and field nonuniformities, reconstruction artifacts were present. Recently, significant progress was made in eliminating most of the reconstruction artifacts with improved field uniformity and alignment. However, artifacts as large as 1/3 of the main peak were still observed at low mass (<17 u). Such artifacts will reduce accuracy in identification and quantification of analytes, reducing the impact of the throughput advantage gained by using a coded aperture. The artifacts were hypothesized to be a result of a mass dependent in curvature of ions in the ion source. Ions with higher mass (m/z > 17 u) and a larger curvature did not pass through all slits in the coded aperture. Therefore, when reconstructing with a system response derived from the aperture image from a higher mass m/z = 32 u ion, reconstruction artifacts appeared for m/z < 17 u. In this work, two methods were implemented to significantly reduce the presence of artifacts in reconstructed data. First, we modified the reconstruction algorithm to incorporate a mass-dependent system response function across the mass range (10–110 u). This method reduced the size of the artifacts by 82%. Second, to validate the hypothesis that the mass-dependent system response function was a result of differences in curvature of ions in the ion source, we modified the design of the ion source by shifting the coded aperture slits relative to the center of the ionization volume. This method resulted in ions of all masses passing through all slits in the coded aperture, a constant system response function across the entire mass range. Artifacts were reduced by 94%.

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Section: Discussionmentioning

confidence: 99%

Spectral Reconstruction Improvement in a Cycloidal Coded-Aperture Mass Spectrometer

Aloui,

Vyas,

Francini

et al. 2024

J. Am. Soc. Mass Spectrom.

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“…[124] and Vyas et al. [125] employed a coded‐aperture method to improve the throughput of magnetic sector analyzers without sacrificing mass resolution (Figure 2D).…”

Section: Instrumentation Of Portable Mass Spectrometersmentioning

confidence: 99%

Portable mass spectrometry system: instrumentation, applications, and path to ‘omics analysis

et al. 2022

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Mass spectrometry (MS) is an information rich analytical technique and plays a key role in various 'omics studies. Standard mass spectrometers are bulky and operate at high vacuum, which hinder their adoption by the broader community and utility in field applications. Developing portable mass spectrometers can significantly expand the application scope and user groups of MS analysis. This review discusses the basics and recent advancements in the development of key components of portable mass spectrometers including ionization source, mass analyzer, detector, and vacuum system. Further, major areas where portable mass spectrometers are applied are also discussed. Finally, a perspective on the further development of portable mass spectrometers including the potential benefits for 'omics analysis is provided.

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“…The large form factor of the IonCCD detector carrier is less suitable for positioning between the poles of the magnet in a cycloidal mass analyzer 47 . In our previous work 16,20,22,52 with cycloidal mass analyzers, we have employed the CTIA array detector as it provides dynamic range exceeding that of a Faraday cup (10 11 ) and sensitivity approaching that of an MCP (~5 ion detection limit). Furthermore, CTIA array detectors have a 100% fill factor, freedom from cross‐talk between pixels, individual pixel programmable gain, ability to operate in a magnetic field, and sensitivity to both positive and negative charge 24,29,30,45,49,51,53 .…”

Section: Design Procedures For a Cycloidal Mass Analyzer Using An Arr...mentioning

confidence: 99%

“…Over the past 50–60 years, use of the cycloidal mass analyzer has been limited to specialized applications, such as underwater mass spectrometry, 11–15 but in the past decade, there has been renewed interest in cycloidal mass analyzers in part due to advances in complementary technologies including ion array detectors, spatial aperture coding, virtual‐slit focusing, and energy‐dense rare‐earth permanent magnets 7,14,16–25 . In particular, placing an array detector at the focal plane of a cycloidal mass analyzer enables simultaneous detection of a wide range of m/q without scanning, improves ratio accuracy and precision, removes spectral skew, makes more efficient use of samples, and enables techniques such as aperture coding and virtual‐slit focusing 26–30 .…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] Over the past 50-60 years, use of the cycloidal mass analyzer has been limited to specialized applications, such as underwater mass spectrometry, [11][12][13][14][15] but in the past decade, there has been renewed interest in cycloidal mass analyzers in part due to advances in complementary technologies including ion array detectors, spatial aperture coding, virtualslit focusing, and energy-dense rare-earth permanent magnets. 7,14,[16][17][18][19][20][21][22][23][24][25] In particular, placing an array detector at the focal plane of a cycloidal mass analyzer enables simultaneous detection of a wide range of m/q without scanning, improves ratio accuracy and precision, removes spectral skew, makes more efficient use of samples, and enables techniques such as aperture coding and virtual-slit focusing. [26][27][28][29][30] Amsden et al demonstrated the combination of these technological advances in a proof-of-concept cycloidal coded aperture miniature mass spectrometer (C-CAMMS) instrument that incorporated aperture coding, a Nd-Fe-B based magnetic sector with a uniform 0.3 T magnetic field, and a capacitive transimpedance amplifier (CTIA) focal plane array detector.…”

Section: Introductionmentioning

confidence: 99%

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Design considerations for a cycloidal mass analyzer using a focal plane array detector

et al. 2022

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With the advent of technologies such as ion array detectors and high energy permanent magnet materials, there is renewed interest in the unique focusing properties of the cycloidal mass analyzer and its ability to enable small, high‐resolution, and high‐sensitivity instruments. However, most literature dealing with the design of cycloidal mass analyzers assumes a single channel detector because at the time of those publications, compatible multichannel detectors were not available. This manuscript introduces and discusses considerations and a procedure for designing cycloidal mass analyzers coupled with focal plane ion array detectors. To arrive at a set of relevant design considerations, we first review the unique focusing properties of the cycloidal mass analyzer and then present calculations detailing how the dimensions and position of the focal plane array detector relative to the ion source determine the possible mass ranges and resolutions of a cycloidal mass analyzer. We present derivations and calculations used to determine the volume of homogeneous electric and magnetic fields needed to contain the ion trajectories and explore the relationship between electric and magnetic field homogeneity on resolving power using finite element analysis (FEA) simulations. A set of equations relating the electric field homogeneity to the geometry of the electric sector electrodes was developed by fitting homogeneity values from 78 different FEA models. Finally, a sequence of steps is suggested for designing a cycloidal mass analyzer employing an array detector.

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Improving the Performance of a Cycloidal Coded-Aperture Miniature Mass Spectrometer

Cited by 6 publications

References 51 publications

Spectral Reconstruction Improvement in a Cycloidal Coded-Aperture Mass Spectrometer

Spectral Reconstruction Improvement in a Cycloidal Coded-Aperture Mass Spectrometer

Portable mass spectrometry system: instrumentation, applications, and path to ‘omics analysis

Design considerations for a cycloidal mass analyzer using a focal plane array detector

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