Improving the osteogenic and angiogenic properties of synthetic hydroxyapatite by dual doping of bivalent cobalt and magnesium ion

Kulanthaivel, Senthilguru; Mishra, Upasana; Agarwal, Tarun; Giri, Supratim; Pal, Kunal; Pramanik, Krishna; Banerjee, Indranil

doi:10.1016/j.ceramint.2015.05.090

Cited by 99 publications

(37 citation statements)

References 44 publications

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“…Three wells without nano‐particles were considered as a control group. After incubation period, MTT assay was performed to evaluate the cell viability index of each well …”

Section: Methodsmentioning

confidence: 99%

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Rare‐earth‐doped SiO₂‐CaF₂ glass ceramic nano‐particle with upconversion properties

Dash

Pal

Banerjee

et al. 2017

Int J Applied Ceramic Tech

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Rare-earth-doped upconversion nano-phosphor shows new possibilities in the field of bioimaging because of its unique properties like higher penetration depth, low signal to noise ratio (SNR), good photo stability, and zero auto fluorescence. The oxyfluoride glass system is the combination of both fluoride and oxide where fluoride host offers high optical transparency due to low phonon energy and oxide network offers high physical stability. Thus, in the present work, an attempt has been made to synthesize 1 mol% Er 3+ doped SiO 2 -CaF 2 glass ceramic nano-particles through sol-gel route. The synthesized glass ceramic particles were heat treated at 4 different temperatures starting from 600°C to 900°C.The X-ray K E Y W O R D Serbium/erbium compounds, glass-ceramics, rare earths, sol-gel

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“…Three wells without nano‐particles were considered as a control group. After incubation period, MTT assay was performed to evaluate the cell viability index of each well …”

Section: Methodsmentioning

confidence: 99%

“…After incubation period, MTT assay was performed to evaluate the cell viability index of each well. 12 3 | RESULTS AND DISCUSSION…”

Section: Methodsmentioning

confidence: 99%

Rare‐earth‐doped SiO₂‐CaF₂ glass ceramic nano‐particle with upconversion properties

Dash

Pal

Banerjee

et al. 2017

Int J Applied Ceramic Tech

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“…Dual ionic substitutions can be considered as a promising strategy to improve the physicochemical and biological properties of HAp. Mostly, both of the two considered vicarious ions are cations, whereas in some cases the anion/anion and anion/cation combinations were investigated. As expected, HAp gets different physico‐chemical properties and biological performances on the basis of the vicarious ions kinds and amounts.…”

Section: Bi‐substituted Hydroxyapatite Powdersmentioning

confidence: 99%

“…Further cation/cation co‐dopings were attempted by Kulanthaivel et al and Gopi et al In details, Kulanthaivel et al synthesised Co/Mg co‐substituted HAp powders by precipitation, causing a slight distortion in the crystal structure, as testified by the related XRD patterns, enhanced hydrophilicity, as corroborated by the water typical functional groups revealed in the FTIR spectrum, and decreased thermal stability, as evidenced by thermogravimetric (TGA) analysis. Gopi et al synthesised Sr 2+ /Ce 3+ co‐substituted hydroxyapatite nanoparticles by microwave irradiation method and Ag + /Mg 2+ co‐doped HAp powder by ultrasonic irradiation technique, in order to improve the HAp bioactivity and antibacterial activity through the incorporation of strontium (Sr 2+ ) or magnesium (Mg 2+ ) and cerium (Ce 3+ , concentration range 0.05‐0.10 mol/L) or silver (Ag + ), respectively.…”

Section: Bi‐substituted Hydroxyapatite Powdersmentioning

confidence: 99%

Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances

Cacciotti

2019

Int J Applied Ceramic Tech

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The biological apatite, whose the bone and teeth mineral phases are composed, remarkably differs from stoichiometric hydroxyapatite (HAp, Ca10(PO4)6(OH)2, Ca/P = 1.667). Indeed, it consists in carbonated Ca‐deficient (Ca/P < 1.667) apatite, characterised by the presence of several vicarious ions, either incorporated within the apatite lattice or just adsorbed on the crystal surface, including anionic (eg, F−, Cl−, SiO44- and CO3=) and/or cationic substitutions (eg, Na+, Mg2+, K+, Sr2+, Zn2+, Ba2+, Al3+). For this reason, recently, a continuous and rising attention has been devoted to the ionic substitutions within the hydroxyapatite lattice in order to resemble the chemical composition of the bone mineral component and to improve its chemical, physical and mostly biological properties, for applications in biomedical sector, particularly in dentistry, orthopaedics and bone tissue engineering. The present manuscript provides a complete overview about the bi‐substituted hydroxyapatites in form of powders and coatings, in order to evidence the effect of the co‐doping with different vicarious ions within HAp lattice on its physicochemical properties, such as microstructure, morphology, thermal stability, solubility, thermal decomposition, dissolution, grain size, mechanical strength, degradation kinetics, corrosion resistance, and biological responsiveness, in terms of in vitro bioactivity, cytotoxicity and antibacterial action.

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“…22,23 Moreover, the vascular development always precedes the osteogenesis, and bone tissue ingrowth greatly depends on the vascularization. Under the circumstance of a well-developed vascular network, the osteoblasts produce osteoid, calcify and differentiate to osteocytes and exhibit healthy bone formation.…”

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confidence: 99%

Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate

Cao¹,

Weng²,

Chen³

et al. 2017

IJN

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Nanoporous lithium doping magnesium silicate (nl-MS) was introduced into calcium sulfate hemihydrate to prepare calcium sulfate composite (nl-MSC) bone cements. The introduction of nl-MS improved the in vitro degradability of nl-MSC cements, which could neutralize acidic degradable products of calcium sulfate and prevented the pH from dropping. The cements were implanted into the bone defects of femur bone of rabbits, and the results of histological and immunohistochemical analysis revealed that massive new bone tissue formed in the defects while the cements were degradable, indicating that the osteogenesis and degradability of the nl-MSC cements were much better than the control calcium sulfate dihydrate (CSD) cements. Furthermore, the positive expression of vascular endothelial growth factor and collagen type I for nl-MSC cements was higher than CSD, indicating that addition of nl-MS into the cements enhanced vascularization and osteogenic differentiation. The results suggested that the nl-MSC cements with good biocompatibility and degradability could promote vascularization and osteogenesis, and had great potential to treat bone defects.

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Improving the osteogenic and angiogenic properties of synthetic hydroxyapatite by dual doping of bivalent cobalt and magnesium ion

Cited by 99 publications

References 44 publications

Rare‐earth‐doped SiO₂‐CaF₂ glass ceramic nano‐particle with upconversion properties

Rare‐earth‐doped SiO₂‐CaF₂ glass ceramic nano‐particle with upconversion properties

Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances

Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate

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Improving the osteogenic and angiogenic properties of synthetic hydroxyapatite by dual doping of bivalent cobalt and magnesium ion

Cited by 99 publications

References 44 publications

Rare‐earth‐doped SiO2‐CaF2 glass ceramic nano‐particle with upconversion properties

Rare‐earth‐doped SiO2‐CaF2 glass ceramic nano‐particle with upconversion properties

Multisubstituted hydroxyapatite powders and coatings: The influence of the codoping on the hydroxyapatite performances

Promotion of in vivo degradability, vascularization and osteogenesis of calcium sulfate-based bone cements containing nanoporous lithium doping magnesium silicate

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Rare‐earth‐doped SiO₂‐CaF₂ glass ceramic nano‐particle with upconversion properties

Rare‐earth‐doped SiO₂‐CaF₂ glass ceramic nano‐particle with upconversion properties