The necessity for quality and safety improvement initiatives permeates health care. Patient safety is one of the major goals adapted national wide especially by World Health Organization (WHO). According to national guidelines, patient safety skills should be part of everyday nursing work. The nurses must have knowledge and skills to prevent any possible harm to patients. Objective: To assess the perceptions and knowledge on patient safety among nurse's students. Method: The study uses descriptive cross-sectional design to study among 105 nurses selected through purposive sampling technique at selected hospital, Kerala. The data was collected using patient safety tool developed by Texas-Memorial Hermann Centre for Healthcare Quality and Safety and demographic questionnaire. The data were analysed using the statistical software SPSS 22 version. Results: The results of the study showed the age of most nurses were between 21 and 29 years (78.6%). Most participants had 1-5 years of experience in nursing (60.3%). Only 34.2% of participants attended at least one course in safety during their experience. There were positive scores (76.8) of nurses perception towards patient safety, and positive scores of four subscales out of six. ANOVA test revealed significant relations between patient safety and nurses' age, experience, degree, and previous attendance of safety courses. On the other hand, analysis of gender, working area, and role of nurses showed no significant differences. Nurses with experience more than 10 years had the most positive responses (F=2.75, p < 0.05). In addition, nurses holding bachelor certificate had more positive scores than those with diploma certificate (F=4.36, p < 0.05). Nurses who attended safety courses had more positive responses than those did not attend. On the other hand, analysis of gender, working area, and role of nurses showed no significant differences. Conclusion: The findings of the study will help nurse managers to create awareness of the nurses regarding patient safety should be raised and their related knowledge should be kept up-to-date through more frequent in-service trainings.