Improving the blood compatibility of material surfaces via biomolecule‐immobilized mussel‐inspired coatings

Abstract

In this article, we presented a general protocol to prepare biomolecule-immobilized mussel-inspired polydopamine (PDA) coatings to improve the blood compatibility of broad ranges of material surfaces. It needs only a simple immersion of substrates in dopamine solution at alkaline pH to form mussel-inspired PDA coating, and then immersing the PDA coated substrates into biomolecule solution to conjugate biomolecules. XPS, water contact angle analysis, and protein assay confirmed that biomolecules could be successfully coated on several material surfaces, including nylon, cellulose, and polyethersulfone membrane surfaces. For the protein fouling resistance, the bovine serum albumin (BSA) modified surfaces were more effective than the amino acid modified surfaces. And the platelet adhesion on the BSA-modified material surfaces was obviously depressed. These results indicated that the blood compatibility of the surfaces was improved by the biomacromolecule-immobilized mussel-inspired coating which might be considered as a universal coating to modify a wide variety of materials.

Synthesis of a novel zwitterionic biodegradable poly (α,β-l-aspartic acid) derivative with some l-histidine side-residues and its resistance to non-specific protein adsorption

“…Actually, those reactions in biology mostly occur at interfaces [10,11], thus it is very necessary for surface modification to inhibit or prevent protein adsorption [12]. The non-cytotoxicity of the materials is also required for biomedical applications [13][14][15].…”

Immobilization of epidermal growth factor on titanium and stainless steel surfaces via dopamine treatment

“…This reaction is considered as the formation of a dopamine-melanin layer on the surface [46,47]. These treatments provide not only organic layers but also further immobilization of biological molecules on the surface of various materials [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62].…”

Deposition Mechanism and Properties of Thin Polydopamine Films for High Added Value Applications in Surface Science at the Nanoscale

“…The blood compatibility of nylon, cellulose, and polyethersulfone decorated with polydopamine films was demonstrated by means of platelet adhesion [122].…”