Improving Surgical Site Infection Rates Through Continuous Quality Improvement

Bakkum-Gamez, Jamie N.; Dowdy, Sean C.

doi:10.1245/s10434-016-5524-5

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…[ 1 ] In 2017, the statistical analysis of registered hospitals in the United States reported that the death rate among patients with SSI was 77%, and for patients with depressed immune systems, such as those with ovarian cancer, SSI increases the death risk rate by 50%. [ 2 ] This statistical data demonstrates the significant number of fatalities caused by SSI. The Centers for Disease Control and Prevention (CDC) Guideline for Disinfection and Sterilization in Healthcare Facilities in the United States was released in 2008, which is the basic protocol followed by hospitals all over the world as a precautionary step to reduce the SSI rate.…”

Section: Introductionmentioning

confidence: 80%

Sol‐gel coupled ultrasound synthesis of photo‐activated magnesium oxide nanoparticles: Optimization and antibacterial studies

et al. 2020

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The alarming transmission rate of surgical site infections (SSI) in hospitals due to ineffective sterilization has encouraged researchers to search for a safe and easily available antibacterial agent. Common sterilization methods involving UV radiation and fumigants lead to hazardous effects on the environment and humans. These drawbacks have caused researchers to shift their attention towards visible light to activate certain materials to act as antibacterial agents. Thus, the present work reports optimization and antibacterial studies of sol-gel coupled ultrasound synthesis of photo-activated magnesium oxide (MgO) nanoparticles. The transmission electron microscope (TEM) and diffuse reflectance spectroscopy (DRS) analysis confirmed that smaller sized particles ranging from 13 nm-25 nm are formed with narrower bandgap of 2.54 eV (1 eV = 1.602 × 10 −19 J). The size reduction in the MgO nanoparticles narrowed their band gap, compared to previous results, which extends their absorptivity of light wavelength from UV (<400 nm) to the visible light region (400-550 nm). The disc diffusion antibacterial analysis optimized using response surface methodology (RSM) revealed that a 0.01 mol/L MgO nanoparticle concentration of 531 μL dosages exhibited a maximum zone of inhibition (ZoI) of 54.1 mm against E. coli, which was achieved with a visible light distance of 5.7 cm. Similarly, a maximum ZoI of 61.3 mm for S. aureus was obtained with a visible light distance of 5 cm and MgO concentration and dosage of 0.01 mol/L and 401 μL. This study confirms the ability of MgO nanoparticle as an alternate and better antibacterial agent via photoactivation for the first time. These photo-activated MgO nanoparticles will be beneficial in the possible inhibition of bacterial growth in surgical equipment, lab coats, or even as antibacterial paints in hospitals.

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Section: Introductionmentioning

confidence: 80%

Sol‐gel coupled ultrasound synthesis of photo‐activated magnesium oxide nanoparticles: Optimization and antibacterial studies

et al. 2020

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“…Medical, quality of care and financial incentives have generated pressure to reduce SSI rates for all surgical specialties 7 . Among universally effective strategies were the standardization of protocols for skin preparation and antisepsis and for use of preoperative antibiotics 8 , 9 . Despite their adoption in obstetrics, 6–10% of CDs continue to develop SSIs 7 , 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

Skin Microbiota in Obese Women at Risk for Surgical Site Infection After Cesarean Delivery

Rood

Buhimschi

Jurcisek

et al. 2018

Sci Rep

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The obesity pandemic in the obstetrical population plus increased frequency of Cesarean delivery (CD) has increased vulnerability to surgical site infection (SSI). Here we characterized the microbiome at the site of skin incision before and after CD. Skin and relevant surgical sites were sampled before and after surgical antisepsis from obese (n = 31) and non-obese (n = 27) pregnant women. We quantified bacterial biomass by qPCR, microbial community composition by 16sRNA sequencing, assigned operational taxonomic units, and stained skin biopsies from incision for bacteria and biofilms. In obese women, incision site harbors significantly higher bacterial biomass of lower diversity. Phylum Firmicutes predominated over Actinobacteria, with phylotypes Clostridales and Bacteroidales over commensal Staphylococcus and Propionbacterium spp. Skin dysbiosis increased post-surgical prep and at end of surgery. Biofilms were identified post-prep in the majority (73%) of skin biopsies. At end of surgery, incision had significant gains in bacterial DNA and diversity, and obese women shared more genera with vagina and surgeon’s glove in CD. Our findings suggest microbiota at incision differs between obese and non-obese pregnant women, and changes throughout CD. An interaction between vaginal and cutaneous dysbiosis at the incision site may explain the a priori increased risk for SSI among obese pregnant women.

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Cold atmospheric plasma is a viable solution for treating orthopedic infection: a review

Nguyen

Lü²,

Boehm³

et al. 2018

Biological Chemistry

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Bacterial infection and antibiotic resistance are major threats to human health and very few solutions are available to combat this eventuality. A growing number of studies indicate that cold (non-thermal) plasma treatment can be used to prevent or eliminate infection from bacteria, bacterial biofilms, fungi and viruses. Mechanistically, a cold plasma discharge is composed of high-energy electrons that generate short-lived reactive oxygen and nitrogen species which further react to form more stable compounds (NO2, H2O2, NH2Cl and others) depending on the gas mixture and plasma parameters. Cold plasma devices are being developed for medical applications including infection, cancer, plastic surgery applications and more. Thus, in this review we explore the potential utility of cold plasma as a non-antibiotic approach for treating post-surgical orthopedic infections.

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Improving Surgical Site Infection Rates Through Continuous Quality Improvement

Cited by 3 publications

References 16 publications

Sol‐gel coupled ultrasound synthesis of photo‐activated magnesium oxide nanoparticles: Optimization and antibacterial studies

Sol‐gel coupled ultrasound synthesis of photo‐activated magnesium oxide nanoparticles: Optimization and antibacterial studies

Skin Microbiota in Obese Women at Risk for Surgical Site Infection After Cesarean Delivery

Cold atmospheric plasma is a viable solution for treating orthopedic infection: a review

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