Improving PEEK bioactivity for craniofacial reconstruction using a 3D printed scaffold embedded with mesenchymal stem cells

Roskies, Michael; Jordan, Jack; Fang, Dongdong; Abdallah, Mohamed‐Nur; Hier, Michael P.; Mlynarek, Alex; Tran, Simon D.

doi:10.1177/0885328216638636

Cited by 94 publications

(85 citation statements)

References 29 publications

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“…Initial reports of bone ingrowth into porous PEEK implants supported this view, yet, until now, porous PEEK technologies in the literature had yet to reach clinical use and remained at various stages of development (Table 1) 13,32–39 . Herein, we describe a new porous PEEK biomaterial with similar physical and mechanical properties of standard PEEK that is able to osseointegrate without the typical fibrous tissue response associated with current smooth PEEK implants.…”

Section: Introductionmentioning

confidence: 99%

Getting PEEK to Stick to Bone: The Development of Porous PEEK for Interbody Fusion Devices

Torstrick

Safranski

Burkus

et al. 2017

Techniques in Orthopaedics

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Interbody fusion cages are routinely implanted during spinal fusion procedures to facilitate arthrodesis of a degenerated or unstable vertebral segment. Current cages are most commonly made from polyether-ether-ketone (PEEK) due to its favorable mechanical properties and imaging characteristics. However, the smooth surface of current PEEK cages may limit implant osseointegration and may inhibit successful fusion. We present the development and clinical application of the first commercially available porous PEEK fusion cage (COHERE®, Vertera, Inc., Atlanta, GA) that aims to enhance PEEK osseointegration and spinal fusion outcomes. The porous PEEK structure is extruded directly from the underlying solid and mimics the structural and mechanical properties of trabecular bone to support bone ingrowth and implant fixation. Biomechanical testing of the COHERE® device has demonstrated greater expulsion resistance versus smooth PEEK cages with ridges and greater adhesion strength of porous PEEK versus plasma-sprayed titanium coated PEEK surfaces. In vitro experiments have shown favorable cell attachment to porous PEEK and greater proliferation and mineralization of cell cultures grown on porous PEEK versus smooth PEEK and smooth titanium surfaces, suggesting that the porous structure enhances bone formation at the cellular level. At the implant level, preclinical animal studies have found comparable bone ingrowth into porous PEEK as those previously reported for porous titanium, leading to twice the fixation strength of smooth PEEK implants. Finally, two clinical case studies are presented demonstrating the effectiveness of the COHERE® device in cervical spinal fusion.

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Section: Introductionmentioning

confidence: 99%

Getting PEEK to Stick to Bone: The Development of Porous PEEK for Interbody Fusion Devices

Torstrick

Safranski

Burkus

et al. 2017

Techniques in Orthopaedics

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show abstract

“…Roskies et al demonstrated that porous polyetheretherketone (PEEK) scaffold can be prepared using SLS technology, which is capable of maintain the biological activity of cells and is conducive to the differentiation of osteoblasts [45].…”

Section: Selective Laser Sinteringmentioning

confidence: 99%

Application of 3D printing technology in bone tissue engineering

Wang

Wei

et al. 2018

Bio-des. Manuf.

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“…SLS can also be used to produce polyetheretherketone (PEEK) scaffolds that are widely applied in orthopedic surgery. Roskies et al (2016) used SLS to fabricate customized porous PEEK scaffolds for seeding mesenchymal stem cells (MSCs) to enhance osteodifferentiation.…”

Section: Selective Laser Sinteringmentioning

confidence: 99%

Rapid prototyping technology and its application in bone tissue engineering

Yuan

Zhou

Chen

2017

J. Zhejiang Univ. Sci. B

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Bone defects arising from a variety of reasons cannot be treated effectively without bone tissue reconstruction. Autografts and allografts have been used in clinical application for some time, but they have disadvantages. With the inherent drawback in the precision and reproducibility of conventional scaffold fabrication techniques, the results of bone surgery may not be ideal. This is despite the introduction of bone tissue engineering which provides a powerful approach for bone repair. Rapid prototyping technologies have emerged as an alternative and have been widely used in bone tissue engineering, enhancing bone tissue regeneration in terms of mechanical strength, pore geometry, and bioactive factors, and overcoming some of the disadvantages of conventional technologies. This review focuses on the basic principles and characteristics of various fabrication technologies, such as stereolithography, selective laser sintering, and fused deposition modeling, and reviews the application of rapid prototyping techniques to scaffolds for bone tissue engineering. In the near future, the use of scaffolds for bone tissue engineering prepared by rapid prototyping technology might be an effective therapeutic strategy for bone defects.

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Improving PEEK bioactivity for craniofacial reconstruction using a 3D printed scaffold embedded with mesenchymal stem cells

Cited by 94 publications

References 29 publications

Getting PEEK to Stick to Bone: The Development of Porous PEEK for Interbody Fusion Devices

Getting PEEK to Stick to Bone: The Development of Porous PEEK for Interbody Fusion Devices

Application of 3D printing technology in bone tissue engineering

Rapid prototyping technology and its application in bone tissue engineering

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