Improving outcomes in intracerebral hemorrhage through microglia/macrophage-targeted IL-10 delivery with phosphatidylserine liposomes

Han, Ranran; Lan, Xi; Zheng, Han; Ren, Honglei; Aafreen, Safiya; Wang, Wenshen; Hou, Zhipeng; Zhu, Tongyu; Ai-dong, Qian; Han, Xiaoning; Koehler, Raymond C.; Liu, Guanshu

doi:10.1016/j.biomaterials.2023.122277

Cited by 4 publications

(3 citation statements)

References 89 publications

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“…Furthermore, the AIE property of TPAM NPs and TPAMCF NPs was tested in EA/water mixtures with EA fractions of 0 and 99%. According to the fluorescence spectra shown in Figure F, TPAM NPs and TPAMCF NPs both exhibited a strong fluorescence emission in a 99% EA/water system with the peak at 650 nm, while no fluorescence was detected in an aqueous solution due to nonradiative transition . Low-polarity solvents such as EA were likely to enter the hydrophobic cores of TPAMCF NPs, and then TPA exhibited intense fluorescence in the aggregation state .…”

Section: Resultsmentioning

confidence: 99%

“…According to the fluorescence spectra shown in Figure 1F, TPAM NPs and TPAMCF NPs both exhibited a strong fluorescence emission in a 99% EA/water system with the peak at 650 nm, while no fluorescence was detected in an aqueous solution due to nonradiative transition. 31 Low-polarity solvents such as EA were likely to enter the hydrophobic cores of TPAMCF NPs, and then TPA exhibited intense fluorescence in the aggregation state. 27 This result implied that TPAMCF NPs had favorable dispersion in highly polar solvents such as water and, thus, fluorescence emission in low-polarity environments, such as LD.…”

Section: Lipid-activatable Property Of Tpamentioning

confidence: 99%

“…Apoptotic macrophages release proteases to destabilize the fibrous cap and leak tissue factor to trigger thrombosis . Phosphatidylserine (PS) is an attractive target for imaging apoptosis because it is transferred onto the exterior surface of the apoptotic cells, it represents a high-capacity target, and PS externalization is an early marker of apoptosis. − PS targeting with fluorescent annexin V has been widely employed for noninvasive imaging of apoptosis . However, protein implementation has also many issues in clinical applications because of the cost of production, endogenous competition, and the restrained diffusion to the targeted sites .…”

Section: Introductionmentioning

confidence: 99%

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Reactive Oxygen Species-Responsive Sequentially Targeted AIE Fluorescent Probe for Precisely Identifying the Atherosclerotic Plaques

Liu,

He,

Zhong

et al. 2023

ACS Appl. Mater. Interfaces

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The formation of atherosclerosis is the root cause of various cardiovascular diseases (CVDs). Therefore, effective CVD interventions call for precise identification of the plaques to aid in clinical treatment of such diseases. Herein, a reactive oxygen species (ROS)-responsive sequentially targeted fluorescent probe is developed for atherosclerotic plaque recognition. An aggregation-induced emission active fluorophore is linked to maleimide (polyethylene glycol) hydroxyl with a ROS-responsive cleavable bond, which is further functionalized with CLIKKPF peptide (TPAMCF) for specifically binding to phosphatidylserine of the foam cells. After being assembled in aqueous medium, TPAMCF nanoparticles can efficiently accumulate in the plaques through the high affinity of CLIKKPF to the externalized phosphatidylserine of the foam cells. Activated by the locally accumulated ROS in foam cells, the nanoparticles are interrupted, and then TPA can be released and subsequently identify the lipid droplets inside the foam cells to achieve fluorescence imaging of the plaques. Such nanoprobes have the favorable ROS response performance and exhibit a special target binding to the foam cells in vitro. In addition, nanoprobe-based fluorescence imaging permitted the high-contrast and precise detection of atherosclerosis specimens ex vivo. Therefore, as a promising fluorescent probe, TPAMCF is capable of being a potential candidate for the detection of atherosclerotic plaque.

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Section: Resultsmentioning

confidence: 99%

Section: Lipid-activatable Property Of Tpamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reactive Oxygen Species-Responsive Sequentially Targeted AIE Fluorescent Probe for Precisely Identifying the Atherosclerotic Plaques

Liu,

He,

Zhong

et al. 2023

ACS Appl. Mater. Interfaces

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The application strategy of liposomes in organ targeting therapy

Xun,

Li,

Xue

2024

WIREs Nanomed Nanobiotechnol

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Liposomes—microscopic phospholipid bubbles with bilayered membrane structure—have been a focal point in drug delivery research for the past 30 years. Current liposomes possess a blend of biocompatibility, drug loading efficiency, prolonged circulation and targeted delivery. Tailored liposomes, varying in size, charge, lipid composition, and ratio, have been developed to address diseases in specific organs, thereby enhancing drug circulation, accumulation at lesion sites, intracellular delivery, and treatment efficacy for various organ‐specific diseases. For further successful development of this field, this review summarized liposomal strategies for targeting different organs in series of major human diseases, including widely studied cardiovascular diseases, liver and spleen immune diseases, chronic or acute kidney injury, neurodegenerative diseases, and organ‐specific tumors. It highlights recent advances of liposome‐mediated therapeutic agent delivery for disease intervention and organ rehabilitation, offering practical guidelines for designing organ‐targeted liposomes.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology‐Inspired Nanomaterials > Lipid‐Based Structures

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Astrocyte‐derived Interleukin‐31 causes poor prognosis in elderly patients with intracerebral hemorrhage

Jiang,

Lu,

Wang

et al. 2024

Brain Pathology

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The incidence of intracerebral hemorrhage (ICH) is increasing every year, with very high rates of mortality and disability. The prognosis of elderly ICH patients is extremely unfavorable. Interleukin, as an important participant in building the inflammatory microenvironment of the central nervous system after ICH, has long been the focus of neuroimmunology research. However, there are no studies on the role IL31 play in the pathologic process of ICH. We collected para‐lesion tissue for immunofluorescence and flow cytometry from the elderly and young ICH patients who underwent surgery. Here, we found that IL31 expression in the lesion of elderly ICH patients was significantly higher than that of young patients. The activation of astrocytes after ICH releases a large amount of IL31, which binds to microglia through IL31R, causing a large number of microglia to converge to the hematoma area, leading to the spread of neuroinflammation, apoptosis of neurons, and ultimately resulting in poorer recovery of nerve function. Interfering with IL31 expression suppresses neuroinflammation and promotes the recovery of neurological function. Our study demonstrated that elderly patients release more IL31 after ICH than young patients. IL31 promotes the progression of neuroinflammation, leading to neuronal apoptosis as well as neurological decline. Suppression of high IL31 concentrations in the brain after ICH may be a promising therapeutic strategy for ICH.

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Improving outcomes in intracerebral hemorrhage through microglia/macrophage-targeted IL-10 delivery with phosphatidylserine liposomes

Cited by 4 publications

References 89 publications

Reactive Oxygen Species-Responsive Sequentially Targeted AIE Fluorescent Probe for Precisely Identifying the Atherosclerotic Plaques

Reactive Oxygen Species-Responsive Sequentially Targeted AIE Fluorescent Probe for Precisely Identifying the Atherosclerotic Plaques

The application strategy of liposomes in organ targeting therapy

Astrocyte‐derived Interleukin‐31 causes poor prognosis in elderly patients with intracerebral hemorrhage

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