Improving imprinted shape cavities of molecularly imprinted sol–gel host matrix with minimal relaxation for sensing of creatinine

Ang, Qian Yee; Chan, Florence; Tan, Pei Chin; Low, Siew Chun

doi:10.1007/s10971-018-4608-z

Cited by 4 publications

(3 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As reported by Ang and Low (2015), the overall binding activity of a creatinine-based MIP (molar ratio of template:cross-linker:monomer = 1:5:5) was heterogeneously defined using the Freundlich adsorption model with a heterogeneity index of 0.88. In spite of the heterogeneous binding sites in MIPs, the: shape factor retained on the template-induced cavities (Yungerman and Srebnik, 2006; Ang and Low, 2015; Ang et al , 2018); affinity of functional cross-linker (Ang and Low, 2015); and background porosity of the polymer (Yungerman and Srebnik, 2006) will also contribute to the recognition behavior of MIPs. …”

Section: Molecularly Imprinted Polymer In Diagnosticmentioning

confidence: 99%

See 1 more Smart Citation

Feasibility study on molecularly imprinted assays for biomedical diagnostics

Ang

Low

2019

Self Cite

View full text Add to dashboard Cite

Purpose Molecularly imprinted polymers (MIPs) have aroused focus in medicinal chemistry in recent decades, especially for biomedical applications. Considering the exceptional abilities to immobilize any guest of medical interest (antibodies, enzymes, etc.), MIPs is attractive to substantial research efforts in complementing the quest of biomimetic recognition systems. This study aims to review the key-concepts of molecular imprinting, particularly emphasizes on the conformational adaptability of MIPs beyond the usual description of molecular recognition. The optimal morphological integrity was also outlined in this review to acknowledge the successful sensing activities by MIPs. Design/methodology/approach This review highlighted the fundamental mechanisms and underlying challenges of MIPs from the preparation stage to sensor applications. The progress of electrochemical and optical sensing using molecularly imprinted assays has also been furnished, with the evolvement of molecular imprinting as a research hotspot. Findings The lack of standard synthesis protocol has brought about an intriguing open question in the selection of building blocks that are biocompatible to the imprint species of medical interest. Thus, in this paper, the shortcomings associated with the applications of MIPs in electrochemical and optical sensing were addressed using the existing literature besides pointing out possible solutions. Future perspectives in the vast development of MIPs also been postulated in this paper. Originality/value The present review intends to furnish the underlying mechanisms of MIPs in biomedical diagnostics, with the aim in electrochemical and optical sensing while hypothesizing on future possibilities.

show abstract

Section: Molecularly Imprinted Polymer In Diagnosticmentioning

confidence: 99%

“…shape factor retained on the template-induced cavities (Yungerman and Srebnik, 2006; Ang and Low, 2015; Ang et al , 2018);…”

Section: Molecularly Imprinted Polymer In Diagnosticmentioning

confidence: 99%

Feasibility study on molecularly imprinted assays for biomedical diagnostics

Ang

Low

2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, the removal of the template from the complex microcavities is inefficient using Soxhlet extraction, 19,20 therefore to solve this problem supercritical carbon dioxide (scCO 2 ) was selected as a substitute for conventional organic solvents owing to their particular physicochemical properties. 21 As one of the most widely used uids in supercritical uids, scCO 2 has many advantages, including being non-toxic, non-ammable, having a low critical point and easy storage.…”

Section: Introductionmentioning

confidence: 99%