Improving drug biological effects by encapsulation into polymeric nanocapsules

Frank, Luíza Abrahão; Contri, Renata Vidor; Beck, Ruy Carlos Ruver; Pohlmann, Adriana Raffin; Guterres, Sílvia Stanisçuaski

doi:10.1002/wnan.1334

Cited by 125 publications

(50 citation statements)

References 76 publications

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“…The use of submicrometric colloidal nanocarriers such as nanoparticles (NP) lipid and polymeric, nanoemulsions (NE), microemulsions (ME), liposomes, and polymeric micelles is considered a promising system in the pharmaceutical field, because they have numerous advantages over traditional formulations such as: sustained release of the active element; solubilization of lipophilic molecules; use for different routes of administration; protection from chemical and enzymatic degradation of labile molecules; reduction of vegetable oils (VO) volatilization, side effects and dose (Mäder, Mehnert, 2005;Mehnert, Mäder, 2001;Gref, Couvreour, 2006;Couvreur, Vauthier, 2006;Panyam, Labhasetwar, 2003;Soppimath et al, 2001;Ai et al, 2011;Contri et al, 2012;Contri et al, 2014;Dimer et al, 2014;Severino et al, 2015;Frank et al, 2015;Asbahani et al, 2015). However, all systems differ thermodynamic stability, structure, chemical composition, efficiency encapsulation and types of application (Mäder, Mehnert, 2005;Ai et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Bajerski

Michels

Colomé

et al. 2016

Braz. J. Pharm. Sci.

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Vegetable oils present important pharmacological properties, which gained ground in the pharmaceutical field. Its encapsulation in nanoemulsions is considered a promising strategy to facilitate the applicability of these natural compounds and to potentiate the actions. These formulations offer several advantages for topical and systemic delivery of cosmetic and pharmaceutical agents including controlled droplet size, protection of the vegetable oil to photo, thermal and volatilization instability and ability to dissolve and stabilize lipophilic drugs. For these reasons, the aim of this review is to report on some characteristics, preparation methods, applications and especially analyze recent research available in the literature concerning the use of vegetable oils with therapeutic characteristics as lipid core in nanoemulsions, specially from Brazilian flora, such as babassu (Orbignya oleifera), aroeira (Schinus molle L.), andiroba (Carapa guaianiensis), casca-de-anta (Drimys brasiliensis Miers), sucupira (Pterodon emarginatus Vogel) and carqueja doce (Stenachaenium megapotamicum) oils.Uniterms: Plant oils/nanoemulsions/preparation. Plant oils/biological applications. INTRODUCTIONThe use of submicrometric colloidal nanocarriers such as nanoparticles (NP) lipid and polymeric, nanoemulsions (NE), microemulsions (ME), liposomes, and polymeric micelles is considered a promising system in the pharmaceutical field, because they have numerous advantages over traditional formulations such as: sustained release of the active element; solubilization of lipophilic molecules; use for different routes of administration; protection from chemical and enzymatic degradation of labile molecules; reduction of vegetable oils (VO) volatilization, side effects and dose (Mäder, Mehnert, 2005;Mehnert, Mäder, 2001;Gref, Couvreour, 2006;Couvreur, Vauthier, 2006; Panyam, Labhasetwar, 2003;Soppimath et al., 2001;Ai et al., 2011; Contri et al., 2012;Contri et al., 2014;Dimer et al., 2014;Severino et al., 2015;Frank et al., 2015;Asbahani et al., 2015). However, all systems differ thermodynamic stability, structure, chemical composition, efficiency encapsulation and types of application (Mäder, Mehnert, 2005;Ai et al., 2011).The development of suitable nanocarriers for pharmaceutical or cosmetic application requires the adequate selection of their adjuvants such as polymers for nanocapsules (NC), surfactants, and oils (Schaffazick et al., 2003;Alvarez-Román et al., 2001;Bouchemal et al., 2004;Friedrich et al., 2008). Recently, special attention has been given to the type of oily phase used as the core in the preparation of NE. VO has been preferred not only due to the concept that it is safe and biocompatible, but mainly because of the diversity of benefits, and the complex composition of fatty acids can exercise under the skin, protecting it against dehydration, solar radiation, inflammation, insect attack, microorganisms, and viruses (Tadros, Kessell, 2004;Bloise, 2003;Oyedeji, Okeke, 2010;Bakkali et. al., 2008;Harris, 2002; Contri et al, ...

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Section: Introductionmentioning

confidence: 99%

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Bajerski

Michels

Colomé

et al. 2016

Braz. J. Pharm. Sci.

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“…8,9 Different drug-delivering systems such as liposomes, [10][11][12][13] dendrimers, 14,15 polymersomes, 16,17 and carbon-based nanoparticles 18,19 have been tested, but until now, only liposomes and albumin nanoparticles containing anticancer drugs have been used clinically. [20][21][22] Polymeric nanocarriers such as multifunctional lipidcoated nanoparticles 23 and polymeric nanocapsules 24 have encouraging therapeutic applications of nanodrug delivery systems, especially as carriers for anticancer drugs into solid tumors. Those effects are due to excellent endocytosis, passive tumor targeting, high encapsulation efficiency, and high stability of polymeric nanoparticles, allowing for extended time in the circulatory system.…”

Section: Introductionmentioning

confidence: 99%

“…Those effects are due to excellent endocytosis, passive tumor targeting, high encapsulation efficiency, and high stability of polymeric nanoparticles, allowing for extended time in the circulatory system. 24 Our research group developed a hybrid biodegradable nanoparticle called lipid-core nanocapsules (LNCs) that are core-shell structures consisting of a lipid core, composed of sorbitan monostearate (SM) dispersed in capric/caprylic triglyceride (CCT), surrounded by a poly(ε-caprolactone) (PCL) wall, and stabilized by polysorbate 80 micelles at the particle/water interface. 25 Several studies have shown the effectiveness of LNC in carrying different drugs to treat cancer and inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

Novel therapeutic mechanisms determine the effectiveness of lipid-core nanocapsules on melanoma models

Drewes¹,

Fiel²,

Bexiga³

et al. 2016

IJN

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Melanoma is a severe metastatic skin cancer with poor prognosis and no effective treatment. Therefore, novel therapeutic approaches using nanotechnology have been proposed to improve therapeutic effectiveness. Lipid-core nanocapsules (LNCs), prepared with poly(ε-caprolactone), capric/caprylic triglyceride, and sorbitan monostearate and stabilized by polysorbate 80, are efficient as drug delivery systems. Here, we investigated the effects of acetyleugenol-loaded LNC (AcE-LNC) on human SK-Mel-28 melanoma cells and its therapeutic efficacies on melanoma induced by B16F10 in C57B6 mice. LNC and AcE-LNC had z -average diameters and zeta potential close to 210 nm and -10.0 mV, respectively. CytoViva ® microscopy images showed that LNC and AcE-LNC penetrated into SK-Mel-28 cells, and remained in the cytoplasm. AcE-LNC in vitro treatment (18–90×10 9 particles/mL; 1 hour) induced late apoptosis and necrosis; LNC and AcE-LNC (3–18×10 9 particles/mL; 48 hours) treatments reduced cell proliferation and delayed the cell cycle. Elevated levels of nitric oxide were found in supernatant of LNC and AcE-LNC, which were not dependent on nitric oxide synthase expressions. Daily intraperitoneal or oral treatment (days 3–10 after tumor injection) with LNC or AcE-LNC (1×10 12 particles/day), but not with AcE (50 mg/kg/day, same dose as AcE-LNC), reduced the volume of the tumor; nevertheless, intraperitoneal treatment caused toxicity. Oral LNC treatment was more efficient than AcE-LNC treatment. Moreover, oral treatment with nonencapsulated capric/caprylic triglyceride did not inhibit tumor development, implying that nanocapsule supramolecular structure is important to the therapeutic effects. Together, data herein presented highlight the relevance of the supramolecular structure of LNCs to toxicity on SK-Mel-28 cells and to the therapeutic efficacy on melanoma development in mice, conferring novel therapeutic mechanisms to LNC further than a drug delivery system.

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“…7 To solve this limitation, a large number of studies have been published describing new delivery systems such as inclusion complexes with cyclodextrins [8][9][10][11] and nanoparticles. 7,[12][13][14][15] Nanoparticle systems have been considered promising carriers of therapeutic drugs, and the application of these particles as carriers of natural compounds has been extensively studied over the past few years. 16 One of the main challenges in relation to chronic diseases is patient adherence to prescribed treatments.…”

mentioning

confidence: 99%

“…18 Several studies have evaluated the administration of nanocapsules by different routes, namely oral, ocular, cutaneous, vaginal and parenteral, demonstrating the versatility of the systems. 12 Lipid-core nanocapsules (LNCs) are a very specific kind of nontoxic polymeric nanocapsules, 14 in which the oily core is formed by an organogel composed of capric/caprylic triglyceride and sorbitan monostearate. The core chemical composition allows these nanocapsules to control drug penetration in different tissues.…”

mentioning

confidence: 99%

Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery

Menezes

Frank

Lima

et al. 2017

IJN

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Chronic venous insufficiency is characterized by chronic reflux disorder of blood from the peripheral to the central vein, with subsequent venous hypertension and resulting changes in the skin. Traditionally, nonsurgical treatments relied on the use of compression therapy, and more recently a variety of flavonoids have been shown to have positive effects. There have also been developments of more effective drug delivery systems using various textiles and nanotechnology to provide new therapeutic options. Our objective was to use nanotechnology to develop a new formulation containing hesperetin (Hst), a substance not previously used in the treatment of chronic venous insufficiency, impregnated into textile fibers as a possible alternative treatment of venous diseases. We prepared the nanocapsules using the interfacial deposition of preformed polymer method with an Hst concentration of 0.5 mg/mL and then characterized the size and distribution of particles. To quantify the Hst in the samples, we developed an analytical method using high-performance liquid chromatography. Studies of encapsulation efficiency (98.81%±0.28%), microscopy, drug release (free-Hst: 104.96%±12.83%; lipid-core nanocapsule-Hst: 69.90%±1.33%), penetration/permeation, drug content (0.46±0.01 mg/mL) and the effect of washing the textile after drug impregnation were performed as part of the study. The results showed that nanoparticles of a suitable size and distribution with controlled release of the drug and penetration/permeation into the skin layers were achieved. Furthermore, it was established that polyamide was able to hold more of the drug, with a 2.54 times higher content than the cotton fiber; after one wash and after five washes, this relation was 2.80 times higher. In conclusion, this is a promising therapeutic alternative to be further studied in clinical trials.

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Improving drug biological effects by encapsulation into polymeric nanocapsules

Cited by 125 publications

References 76 publications

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Novel therapeutic mechanisms determine the effectiveness of lipid-core nanocapsules on melanoma models

Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery

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