Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima

Skaf, Joseph; Hamarsheh, Omar; Berninger, Michael; Balasubramanian, Srikkanth; Oelschlaeger, Tobias A.; Holzgrabe, Ulrike

doi:10.1016/j.fitote.2017.11.001

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…Moreover, the antileishmanial and antitrypanosomal effects of A. fragrantissima have also been reported. Achillolide A, chrysosplenol-D, chrysosplenetine and pellitorine were identified in the aerial parts of the plant (14). On the other hand, remarkable enzyme inhibitory effects have been also described to Achillea spp.…”

Section: Introductionmentioning

confidence: 99%

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications

Salehi

Selamoğlu

Sevindik

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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The genus Achillea genus houses more than 100 species, a number of them are popularly used in traditional medicine for spasmodic gastrointestinal, gynecological and hepatobiliary disorders, hemorrhages, pneumonia, rheumatic pain, inflammation, wounds healing etc. Members of the genus contain a wide variety of volatile and non-volatile secondary metabolites, including terpenes, polyphenols, flavonoids and others. Multiple studies have assessed the biological effects and other aspects of Achillea spp. In a number of preclinical studies, Achillea plants and their essential oils have demonstrated promising antibacterial properties against a number of human and plant pathogens. Besides, the plants have displayed strong antioxidative and potent anti-proliferative and anticancer properties in various cellular and animal models. Achillea plants have widely been used as food preservative in food industry. Clinical studies have indicated its potential against multiple sclerosis (MS), irritable bowel syndrome (IBS), ulcerative colitis, episiotomy wound, primary dysmenorrhea, oral mucositis etc. The present work focuses to provide a brief overview on folk knowledge, phytochemistry, biological activity and applications of Achillea plants. There is a close relationship between the traditional ethnobotanical usage and pharmacological and clinical data from different Achillea spp. The application of Achillea plants and their extracts seems to be a promising alternative for antimicrobial and antioxidant purposes in food, pharmaceutical and cosmetic industries.

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Section: Introductionmentioning

confidence: 99%

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications

Salehi

Selamoğlu

Sevindik

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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“…Toxicity of SKC3 was additionally assessed in vivo in the greater wax moth larvae, G. mellonella . In recent years, G. mellonella larvae have emerged as an interesting model system for evaluating the toxicity and efficacy of novel compounds and for studying various microbial infections ( Gibreel and Upton, 2013 ; Aparecida Procopio Gomes et al, 2016 ; Skaf et al, 2017 ). The ease of handling, low maintenance costs, absence of ethical concerns, survival at human physiological temperatures are some of the advantages of using G. mellonella larvae for pre-screening of toxicity ( Tsai et al, 2016 ).…”

Section: Resultsmentioning

confidence: 99%

“…Galleria mellonella larvae (at their final stage) were purchased from Mouse Live Bait (Balk, Netherlands). In vivo toxicity of SBT348 extract and SKC3 was assessed in G. mellonella using the method described previously ( Gibreel and Upton, 2013 ; Skaf et al, 2017 ). Healthy larvae (clear in color without the presence of any spots or pigmentation) were used in the experiment.…”

Section: Methodsmentioning

confidence: 99%

A New Bioactive Compound From the Marine Sponge-Derived Streptomyces sp. SBT348 Inhibits Staphylococcal Growth and Biofilm Formation

et al. 2018

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Staphylococcus epidermidis, the common inhabitant of human skin and mucosal surfaces has emerged as an important pathogen in patients carrying surgical implants and medical devices. Entering the body via surgical sites and colonizing the medical devices through formation of multi-layered biofilms leads to refractory and persistent device-related infections (DRIs). Staphylococci organized in biofilms are more tolerant to antibiotics and immune responses, and thus are difficult-to-treat. The consequent morbidity and mortality, and economic losses in health care systems has strongly necessitated the need for development of new anti-bacterial and anti-biofilm-based therapeutics. In this study, we describe the biological activity of a marine sponge-derived Streptomyces sp. SBT348 extract in restraining staphylococcal growth and biofilm formation on polystyrene, glass, medically relevant titan metal, and silicone surfaces. A bioassay-guided fractionation was performed to isolate the active compound (SKC3) from the crude SBT348 extract. Our results demonstrated that SKC3 effectively inhibits the growth (MIC: 31.25 μg/ml) and biofilm formation (sub-MIC range: 1.95–<31.25 μg/ml) of S. epidermidis RP62A in vitro. Chemical characterization of SKC3 by heat and enzyme treatments, and mass spectrometry (HRMS) revealed its heat-stable and non-proteinaceous nature, and high molecular weight (1258.3 Da). Cytotoxicity profiling of SKC3 in vitro on mouse fibroblast (NIH/3T3) and macrophage (J774.1) cell lines, and in vivo on the greater wax moth larvae Galleria mellonella revealed its non-toxic nature at the effective dose. Transcriptome analysis of SKC3 treated S. epidermidis RP62A has further unmasked its negative effect on central metabolism such as carbon flux as well as, amino acid, lipid, and energy metabolism. Taken together, these findings suggest a potential of SKC3 as a putative drug to prevent staphylococcal DRIs.

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“…Sch.Bip. and tested against trypomastigote forms of T. b. brucei [ 61 ]. Lactone 28 was the most active (IC 50 3.03 μM), while lactones 29 and 30 showed the same activity against the parasite with IC 50 value of 10.97 μM.…”

Section: Terpenic Compounds With Antitrypanosomal Activitymentioning

confidence: 99%

Plant Terpenoids as Hit Compounds against Trypanosomiasis

et al. 2022

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Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites Trypanosoma brucei and Trypanosoma cruzi, respectively. These diseases were circumscribed to South American and African countries in the past. However, human migration, military interventions, and climate changes have had an important effect on their worldwide propagation, particularly Chagas disease. Currently, the treatment of trypanosomiasis is not ideal, becoming a challenge in poor populations with limited resources. Exploring natural products from higher plants remains a valuable approach to find new hits and enlarge the pipeline of new drugs against protozoal human infections. This review covers the recent studies (2016–2021) on plant terpenoids, and their semi-synthetic derivatives, which have shown promising in vitro and in vivo activities against Trypanosoma parasites.

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Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima

Cited by 16 publications

References 27 publications

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications

Achillea spp.: A comprehensive review on its ethnobotany, phytochemistry, phytopharmacology and industrial applications

A New Bioactive Compound From the Marine Sponge-Derived Streptomyces sp. SBT348 Inhibits Staphylococcal Growth and Biofilm Formation

Plant Terpenoids as Hit Compounds against Trypanosomiasis

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