Improvements of cellular stress response on resveratrol in liposomes

Kristl, Julijana; Teskač, Karmen; Caddeo, Carla; Abramović, Zrinka; Šentjurc, Marjeta

doi:10.1016/j.ejpb.2009.06.006

Cited by 91 publications

(49 citation statements)

References 33 publications

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“…To the best of our knowledge, the reduction in trans-RSV solubility at pH 7.4 as compared to 1.2 or 6.8 has not been published before. The trans-RSV solubility was determined at 37 °C because this temperature is recommended for dissolution studies in sink conditions [25] and for in vitro experiments on cell lines [41]. However, most studies reported trans-RSV solubility at 25 °C to be 19.6-30 µg/mL [16,42].…”

Section: Tablementioning

confidence: 99%

“…There are several other cell assays including a 24-hour or longer incubation of cells with free or trans-RSVloaded drug delivery systems for a purpose of evaluating its effect on the cell differentiation, morphology, cytotoxicity, survival under stress conditions, antioxidant activity, and intracellular reactive oxygen species levels [5,41,50]. Therefore, it is vital to realize that in the assays conducted under these conditions the effect of trans-RSV would not be evaluated at its predetermined concentration, but at its lower concentration and in the presence of degradation products.…”

Section: Tablementioning

confidence: 99%

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Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature

Zupančič

Lavrič

Kristl

2015

European Journal of Pharmaceutics and Biopharmaceutics

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266

153

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Section: Tablementioning

confidence: 99%

Section: Tablementioning

confidence: 99%

Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature

Zupančič

Lavrič

Kristl

2015

European Journal of Pharmaceutics and Biopharmaceutics

Self Cite

266

153

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“…In phamacodelivery, caveolae might constitute a useful transport pathway by improving tissue-directed drug and gene delivery in vivo [94]; this method could improve RSV access to solid tumour cells. Another way to achieve selective targeting to solid tumours is the use of polymeric micelles [95].…”

Section: Impact Of Rsv Transport On Its Bioavailability and Its Biolomentioning

confidence: 99%

Role of membrane dynamics processes and exogenous molecules in cellular resveratrol uptake: Consequences in bioavailability and activities

Delmas

Lin

2011

Molecular Nutrition Food Res

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In the fields of nutrition prevention and therapy treatment, numerous studies have reported interesting properties of trans-resveratrol (RSV), a natural polyphenol against pathologies such as vascular diseases, cancers, viral infections and neurodegenerative processes. These beneficial effects are supported by more studies showing the pleiotropic actions of RSV. Nevertheless, a crucial question concerning these effects is how the polyphenol, when applied to an organism, gains access to its targets. In this review, we focus on the biochemical and biological parameters involved in RSV transport, particularly the role of the phospholipid bilayer in RSV uptake (passive diffusion, carrier-mediated transport) and of exogenous molecules modulating RSV transport and effects. The dynamic processes of the plasma membrane reveal the importance of the role of lipid composition in the fluidity, the lipid rafts in RSV endocytosis and the ATP-binding cassette transporters in RSV efflux. Specific membrane receptors such as integrin αvβ3 contribute to RSV uptake and to activate signalling pathways involved in apoptosis. We discuss the role of intracellular receptors (i.e. aryl-hydrocarbon and estrogen receptors). In addition, circulating molecules (i.e. albumin, haemoglobin, fatty acids, lipoproteins) play a role as RSV carriers. Finally, we developed a hypothesis concerning the relation between RSV uptake and its biological activities.

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“…It is a lipophilic compound with the logP of 3.1, belonging to BCS class II (27). Pharmacokinetic studies indicated that the oral bioavailability of resveratrol is almost zero (28). Table III shows the solubilities of hymecromone and resveratrol in all SMEDDS formulations and their components.…”

Section: Solubilizing Capability Studymentioning

confidence: 99%

Effect of Lipolysis on Drug Release from Self-microemulsifying Drug Delivery Systems (SMEDDS) with Different Core/Shell Drug Location

Zhang

Zhao

et al. 2014

AAPS PharmSciTech

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Abstract. The objective of this study is to investigate the effect of lipolysis on the release of poorly watersoluble drug from SMEDDS in the perspective of drug core/shell location. For this purpose, four SMEDDS formulations with various core/shell properties were developed based on long-chain lipid or medium-chain lipid as well as different surfactant/oil ratios. Poorly water-soluble drugs, hymecromone and resveratrol, were significantly solubilized in all SMEDDS formulations and the diluted microemulsions. Fluorescence spectra analysis indicated that hymecromone was mainly located in the shell of microemulsions, while resveratrol was located in the core. The effect of lipolysis on the release rates of drugs with different core/shell locations were investigated by a modified in vitro drug release model. For the drug located in the shell, hymecromone, the release profiles were not affected during the lipolysis process and no significant differences were observed among four formulations. For the drug located in the core, resveratrol, the release rates were increased to various degrees depending on the extent of digestion. In conclusion, the drug core/shell location plays an important role for determining the effect of lipolysis on drug release from SMEDDS formulation.

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Improvements of cellular stress response on resveratrol in liposomes

Cited by 91 publications

References 33 publications

Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature

Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature

Role of membrane dynamics processes and exogenous molecules in cellular resveratrol uptake: Consequences in bioavailability and activities

Effect of Lipolysis on Drug Release from Self-microemulsifying Drug Delivery Systems (SMEDDS) with Different Core/Shell Drug Location

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