2015
DOI: 10.1016/j.ejpb.2015.04.002
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Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature

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Cited by 261 publications
(174 citation statements)
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“…These results corroborate widely ignored findings that the stability and oxidation of RSV in physiologically relevant media is strongly influenced by pH and in particular the availability of hydroxyl anions 16,29,32 . Interestingly, RSV reacted also efficiently in tap water (Fig.…”
Section: Rsv Is Unstable Under Physiologically Relevant Conditionssupporting
confidence: 80%
“…These results corroborate widely ignored findings that the stability and oxidation of RSV in physiologically relevant media is strongly influenced by pH and in particular the availability of hydroxyl anions 16,29,32 . Interestingly, RSV reacted also efficiently in tap water (Fig.…”
Section: Rsv Is Unstable Under Physiologically Relevant Conditionssupporting
confidence: 80%
“…We have decided to use the modified European pharmacopeia dissolution method (paddle method). The release conditions, especially the release medium volume, did not meet the physiological conditions in the periodontal pocket but the selected volume enabled obtaining sink conditions of low soluble RSV (61.2 ± 2.1 µg/mL at these conditions [24]). Thus, release profiles of different formulations could be compared.…”
Section: Release Studies From the Hydrophobic Nanofibersmentioning
confidence: 99%
“…The UPLC method was used for analysis of RSV because it was recently reported that it showed better separation between trans-RSV from cis-RSV and degradation products compared to HPLC or UV/VIS spectroscopy [24]. The trans-RSV was determined by the chromatographic system Acquity UPLC (Waters Corp., USA).…”
Section: Rsv Analyticsmentioning
confidence: 99%
“…It possesses a wide range of beneficial effects, including anti-cancer, anti-aging, anti-atherogenic, anti-inflammatory and anti-oxidant activities [1][2][3] . However, its utilization and development in products have been hampered by its poor solubility, poor chemical stability, and low bioavailability [4,5] . Many attempts have sought to improve the bioactivity and bioavailability of Res [6,7] .…”
Section: Introductionmentioning
confidence: 99%