Improvements in life expectancy in adult type 2 diabetes patients in the last six decades

Ioacără, Sorin; Guja, Cristian; Ionescu-Tîrgovişte, C; Fica, Simona; Sabau, Sorin V.; Radu, Stefania; Micu, Andrei; Tiu, Cristina

doi:10.1016/j.diabres.2011.03.022

Cited by 24 publications

(11 citation statements)

References 29 publications

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“…Pathways of oxidative stress and inflammation are commonly observed in obesity, diabetes, and AD. With the availability of a wide range of drugs for managing diabetes and its complications, the life expectancy of persons with diabetes is steadily increasing [137]. The association of obesity and diabetes with AD is likely to be more evident in the future than with the current older population because of survival bias.…”

Section: Discussionmentioning

confidence: 99%

Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease

Pugazhenthi¹,

Qin²,

Reddy³

2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

470

325

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Cognitive decline in chronic diabetic patients is a less investigated topic. Diabetes and obesity are among the modifiable risk factors for Alzheimer's disease (AD), the most common form of dementia. Studies have identified several overlapping neurodegenerative mechanisms, including oxidative stress, mitochondrial dysfunction, and inflammation that are observed in these disorders. Advanced glycation end products generated by chronic hyperglycemia and their receptor RAGE provide critical links between diabetes and AD. Peripheral inflammation observed in obesity leads to insulin resistance and type 2 diabetes. Although the brain is an immune-previleged organ, crosstalks between peripheral and central inflammation have been reported. Damage to the blood brain barrier (BBB) as seen with aging can lead to infiltration of immune cells into the brain, leading to the exacerbation of central inflammation.Neuroinflammation, which has emerged as an important cause of cognitive dysfunction, could provide a central mechanism for aging-associated ailments. To further add to these injuries, adult neurogenesis that provides neuronal plasticity is also impaired in the diabetic brain. This review discusses these molecular mechanisms that link obesity, diabetes and AD.

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Section: Discussionmentioning

confidence: 99%

Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease

Pugazhenthi¹,

Qin²,

Reddy³

2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

470

325

View full text Add to dashboard Cite

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“…With advancements in awareness, detection, and management of the disease, the average life expectancy of patients with diabetes is increasing (Lutgers et al, 2009; Guja et al, 2011; Huo et al, 2016). Thus, the number of individuals living with long-term complications is enhanced.…”

Section: Discussionmentioning

confidence: 99%

Influenza Virus and Glycemic Variability in Diabetes: A Killer Combination?

2017

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Following the 2009 H1N1 influenza virus pandemic, numerous studies identified the striking link between diabetes mellitus and influenza disease severity. Typically, influenza virus is a self-limiting infection but in individuals who have a pre-existing chronic illness, such as diabetes mellitus, severe influenza can develop. Here, we discuss the latest clinical and experimental evidence for the role of diabetes in predisposing the host to severe influenza. We explore the possible mechanisms that underlie this synergy and highlight the, as yet, unexplored role that blood glucose oscillations may play in disease development. Diabetes is one of the world’s fastest growing chronic diseases and influenza virus represents a constant and pervasive threat to human health. It is therefore imperative that we understand how diabetes increases influenza severity in order to mitigate the burden of future influenza epidemics and pandemics.

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“…It is well established that diabetes increases the risk of macro‐ and microvascular diseases and consequently increases the risk of all‐cause mortality . It has been noted that more and more young people are developing diabetes, whereas in reality the overall life expectancy of patients with T2DM has increased markedly . So, some patients are expected to live with diabetes for extremely long periods of time.…”

Section: Introductionmentioning

confidence: 99%