Improvement of the Firocoxib Dissolution Performance Using Electrospun Fibers Obtained from Different Polymer/Surfactant Associations

Maggi, Lauretta; Friuli, Valeria; Chiesa, Enrica; Pisani, Silvia; Sakaj, Mirena; Celestini, Paolo; Bruni, Giovanna

doi:10.3390/ijms20123084

Cited by 12 publications

(4 citation statements)

References 14 publications

(14 reference statements)

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“…Sodium chloride and Benzalkonium chloride solutions added in the above drug-polymeric solution by continuous mixing on the magnetic stirrer at 400 rpm with heating (50 o C on ceramic plate (Thermo Fisher Scientific, Massachusetts USA). Final volume was made up to 100 mL and pH was adjusted with acetate buffer to pH 4 [14]. Entire process of preparation was done under aseptic conditions of BSC class II cabinets (LabGard ES NU-437S Class II Biosafety Cabinet, USA).…”

Section: Preparation Of Fluconazole In-situ Ophthalmic Sol-gelmentioning

confidence: 99%

Smart in-situ thermo-responsive and ion activated ophthalmic sol-gel system of fluconazole

Fatima¹

2021

jrp

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The objective of the current investigation is the development and characterization of in-situ ophthalmic formulation of fluconazole for sustained release at the eye site for a prolong period of time. Sol-gel fluconazole in-situ formulation was prepared by thermo-responsive pluronic F127, Na + activated sodium alginate alone and in combination, characterization parameters include FTIR spectroscopy, Visual assessment and clarity test, Gelling ability test, pH testing, drug assay, In-vitro drug release and optimized formulation was evaluated for In-vitro antifungal studies by comparing with marketed formulation of fluconazole. Optimized formulation F8 composed of fluconazole (0.3%w/v), Pluronic F127(1%w/v), sodium alginate (0.5%w/v), sodium chloride (0.9w/v), benzalkonium Chloride (0.01%w/v) and acetate buffer pH 4 up to 100%w/v), showed drug-polymer compatibility as per FTIR, high gelling consistency on contact with simulated physiological conditions, 6.9 pH, drug assay was estimated (99.89±0.78 %) with 100% in-vitro drug released for about 6 hours. The in-vitro antifungal study was found to be 18.87±0.65 mm; 20.76±0.23 mm in comparison to marketed fluconazole conventional gel formulation (15.98±0.98 mm; 18.98±0.76 mm) for Candida albicans and Aspergillus niger pathogenic fungal strains respectively. Prepared in-situ ophthalmic sol-gel formulation of fluconazole could be considered as efficient delivery system to sustained the drug at the target site and effectively eradicating deeply rooted pathogenic fungal stains.

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Section: Preparation Of Fluconazole In-situ Ophthalmic Sol-gelmentioning

confidence: 99%

Smart in-situ thermo-responsive and ion activated ophthalmic sol-gel system of fluconazole

Fatima¹

2021

jrp

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“…Furthermore, electrospun nanofibers can be loaded with a high amount of bioactive medical substances (up to 40% loading) [48], with antimicrobial and antioxidant activity that can enhance the wound healing. The porous structure of these matrices could facilitate the adsorption of wound exudates, gaseous and nutrients exchange, and prevent bacterial infection [49,50]. Compared to traditional nanofiber drug-delivery systems, electrospun nanofiber dressings could allow for shorter response times and more precise control over the release rate of therapeutic agents for wound healing.…”

Section: The Electrospinning Techniquementioning

confidence: 99%

Nanostructured Fibers Containing Natural or Synthetic Bioactive Compounds in Wound Dressing Applications

Croitoru

Ficai

et al. 2020

Materials

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The interest in wound healing characteristics of bioactive constituents and therapeutic agents, especially natural compounds, is increasing because of their therapeutic properties, cost-effectiveness, and few adverse effects. Lately, nanocarriers as a drug delivery system have been actively investigated and applied in medical and therapeutic applications. In recent decades, researchers have investigated the incorporation of natural or synthetic substances into novel bioactive electrospun nanofibrous architectures produced by the electrospinning method for skin substitutes. Therefore, the development of nanotechnology in the area of dressings that could provide higher performance and a synergistic effect for wound healing is needed. Natural compounds with antimicrobial, antibacterial, and anti-inflammatory activity in combination with nanostructured fibers represent a future approach due to the increased wound healing process and regeneration of the lost tissue. This paper presents different approaches in producing electrospun nanofibers, highlighting the electrospinning process used in fabricating innovative wound dressings that are able to release natural and/or synthetic substances in a controlled way, thus enhancing the healing process.

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“…Recently, electrospinning (ES) has demonstrated to be an attractive strategy to increase the release of poorly soluble drugs [ 16 , 17 ], ranging from antibiotics and anticancer agents to macromolecules such as proteins and DNA [ 18 ]. The improvement of the dissolution rate and/or solubility of the loaded drugs are achieved by the high surface-to-volume ratio of the electrospun nanofibers, the potential amorphization of the active and enhancement of its wettability.…”

Section: Introductionmentioning

confidence: 99%

Tablet Formulations of Polymeric Electrospun Fibers for the Controlled Release of Drugs with pH-Dependent Solubility

et al. 2022

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A challenge in the pharmaceutical sector is the development of controlled release dosage forms for oral administration of poorly soluble drugs, in particular, drugs characterized by pH-dependent solubility through the gastrointestinal tract, which itself shows wide variability in terms of environmental pHs. The best approach is to increase the dissolution rate of the drugs at the different pHs and only then modify its release behavior from the pharmaceutical form. This work aims to demonstrate the ability of properly designed polymeric nanofibers in enhancing the release rate of model drugs with different pH-dependent solubility in the different physiological pHs of the gastrointestinal tract. Polymeric nanofibers loaded with meloxicam and carvedilol were prepared using the electrospinning technique and were then included in properly designed tablet formulations to obtain fast or sustained release dosage forms. The nanofibers and the tablets were characterized for their morphological, physico-chemical and dissolution properties. The tablets are able to deliver the dose according to the expected release behavior, and zero-order, first-order, Higuchi, Korsmeyer–Peppas and Hixon–Crowell kinetics models were used to analyze the prevailing release mechanism of the tablets. This study shows that the electrospun fibers can be advantageously included in oral dosage forms to improve their release performances.

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Improvement of the Firocoxib Dissolution Performance Using Electrospun Fibers Obtained from Different Polymer/Surfactant Associations

Cited by 12 publications

References 14 publications

Smart in-situ thermo-responsive and ion activated ophthalmic sol-gel system of fluconazole

Smart in-situ thermo-responsive and ion activated ophthalmic sol-gel system of fluconazole

Nanostructured Fibers Containing Natural or Synthetic Bioactive Compounds in Wound Dressing Applications

Tablet Formulations of Polymeric Electrospun Fibers for the Controlled Release of Drugs with pH-Dependent Solubility

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