Nanostructured Fibers Containing Natural or Synthetic Bioactive Compounds in Wound Dressing Applications

Croitoru, Alexa-Maria; Ficai, Denisa; Ficai, Anton; Mihăilescu, Natalia; Andronescu, Ecaterina; Turculet, Claudiu Florin

doi:10.3390/ma13102407

Cited by 32 publications

(19 citation statements)

References 92 publications

(114 reference statements)

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“…Development of chronic wounds is a consequence of failure in the normal wound healing process in an orderly and timely manner [ 1 ]. The self-regenerative capacity of cutaneous wounds is lost in chronic wound conditions, which may not be able to achieve anatomical and functional integrity of the damaged tissue by the succession complex stages, such as hemostasis, inflammation, proliferation and resolution within the period of six weeks of medical therapy [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The incidences of chronic wound cases are increasing sharply every year, predominantly in the elderly [ 5 ]. Improper control of chronic wound patients has significant influence on the health, leading to amputation of the extremities, which impact on the quality of life of the patients and sometime leading to death [ 1 ]. Physiological management of chronic wounds could effectively be managed by topical therapies, where control of acidic pH, proper level of moisture, formation of biofilms by the pathogenic bacterial growth and temperature need to be maintained using a biocompatible environment [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy in Wound Healing

et al. 2020

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The potential role of naringenin (NAR), a natural flavonoid, in the treatment of chronic wound has prompted the present research to deliver the drug in nanoemulsion (NE) form, where synergistic role of chitosan was achieved through development of chitosan-coated NAR NE (CNNE). The NE consisted of Capryol 90, Tween 20 and Transcutol P, which was fabricated by low-energy emulsification method to encapsulate NAR within the oil core. The optimization of the formulated NEs was performed using Box–Behnken statistical design to obtain crucial variable parameters that influence globule size, size distribution and surface charge. Finally, the optimized formulation was coated with different concentrations of chitosan and subsequently characterized in vitro. The size of the CNNE was found to be increased when the drug-loaded formulation was coated with chitosan. Controlled release characteristics depicted 67–81% release of NAR from the CNNE, compared to 89% from the NE formulation. Cytotoxicity study of the formulation was performed in vitro using fibroblast cell line (NIH-3T3), where no inhibition in proliferation of the cells was observed with CNNE. Finally, the wound healing potential of the CNNE was evaluated in an abrasion-created wound model in experimental animals where the animals were treated and compared histologically at 0 and 14 days. Significant improvement in construction of the abrasion wound was observed when the animals were treated with formulated CNNE, whereas stimulation of skin regeneration was depicted in the histological examination. Therefore, it could be summarized that the chitosan coating of the developed NAR NE is a potential platform to accelerate healing of wounds.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy in Wound Healing

et al. 2020

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“…Natural products, used in traditional medicine, are among the options for incorporation in polymeric matrices, providing the synergistic effect to accelerate the wound healing process. In this scenario, red propolis appears as an alternative for incorporation in polymeric matrices, due to its biological properties, cost-effectiveness and low adverse effect [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

New Insights for Red Propolis of Alagoas—Chemical Constituents, Topical Membrane Formulations and Their Physicochemical and Biological Properties

Silva

Basílio

et al. 2020

Molecules

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The main objectives of this study were to evaluate the chemical constitution and allergenic potential of red propolis extract (RPE). They were evaluated, using high performance liquid chromatography (HPLC) and the release of β-hexosaminidase, respectively. A plethora of biologically active polyphenols and the absence of allergic responses were evinced. RPE inhibited the release of β-hexosaminidase, suggesting that the extract does not stimulate allergic responses. Additionally, the physicochemical properties and antibacterial activity of hydrogel membranes loaded with RPE were analyzed. Bio-polymeric hydrogel membranes (M) were obtained using 5% carboxymethylcellulose (M1 and M2), 1.0% of citric acid (M3) and 10% RPE (for all). Their characterization was performed using thermal analysis, Fourier transform infrared (FTIR), total phenolic content, phenol release test and, antioxidant activity through 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and Ferric Reducing Antioxidant Power (FRAP). The latter appointed to the similar antioxidant capacity of the M1, M2 and M3. The degradation profiles showed higher thermostability to M3, followed by M2 and M1. The incorporation of RPE into the matrices and the crosslinking of M3 were evinced by FTIR. There were differences in the release of phenolic compounds, with a higher release related to M1 and lower in the strongly crosslinked M3. The degradation profiles showed higher thermostability to M3, followed by M2 and M1. The antibacterial activity of the membranes was determined using the disc diffusion assay, in comparison with controls, obtained in the same way, without RPE. The membranes elicited antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis, with superior performance over M3. The hydrogel membranes loaded with RPE promote a physical barrier against bacterial skin infections and may be applied in the wound healing process.

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“…HA can be an outstanding drug delivery carrier for numerous therapeutic agents as a result of its high stability, bioactivity, biocompatibility, and lack of toxicity [ 63 ]. In addition, biodegradable polymers have wide usage as drug delivery systems due to their biodegradability and biocompatibility, and, among them, aliphatic polyester (PLA), proteins (collagen, gelatin) or polysaccharides (alginate, chitosan) have the ability to extend the releasing of drugs from some days till some months [ 57 , 64 , 65 , 66 ].…”

Section: Drug Deliverymentioning

confidence: 99%

Advances in Osteoporotic Bone Tissue Engineering

Codrea

Croitoru

Baciu

et al. 2021

JCM

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The increase in osteoporotic fracture worldwide is urging bone tissue engineering research to find new, improved solutions both for the biomaterials used in designing bone scaffolds and the anti-osteoporotic agents capable of promoting bone regeneration. This review aims to report on the latest advances in biomaterials by discussing the types of biomaterials and their properties, with a special emphasis on polymer-ceramic composites. The use of hydroxyapatite in combination with natural/synthetic polymers can take advantage of each of their components properties and has a great potential in bone tissue engineering, in general. A comparison between the benefits and potential limitations of different scaffold fabrication methods lead to a raised awareness of the challenges research face in dealing with osteoporotic fracture. Advances in 3D printing techniques are providing the ways to manufacture improved, complex, and specialized 3D scaffolds, capable of delivering therapeutic factors directly at the osteoporotic skeletal defect site with predefined rate which is essential in order to optimize the osteointegration/healing rate. Among these factors, strontium has the potential to increase osseointegration, osteogenesis, and healing rate. Strontium ranelate as well as other biological active agents are known to be effective in treating osteoporosis due to both anti-resorptive and anabolic properties but has adverse effects that can be reduced/avoided by local release from biomaterials. In this manner, incorporation of these agents in polymer-ceramic composites bone scaffolds can have significant clinical applications for the recovery of fractured osteoporotic bones limiting or removing the risks associated with systemic administration.

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Nanostructured Fibers Containing Natural or Synthetic Bioactive Compounds in Wound Dressing Applications

Cited by 32 publications

References 92 publications

Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy in Wound Healing

Development and Optimization of Naringenin-Loaded Chitosan-Coated Nanoemulsion for Topical Therapy in Wound Healing

New Insights for Red Propolis of Alagoas—Chemical Constituents, Topical Membrane Formulations and Their Physicochemical and Biological Properties

Advances in Osteoporotic Bone Tissue Engineering

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